Capmul PG-12 is a propylene glycol monoester of medium-chain fatty acids, mainly lauric acid. It is an excellent solubilizer for many complex, poorly-soluble drug compounds. Capmul PG-12 is used primarily as a secondary emulsifier in microemulsions. It is manufactured in USA.

INCI Name: Propylene Glycol Laurate

Functions: Anti-Microbial Agent, Carrier, Conditioner, Emollient, Emulsifier, Emulsifier, Emulsifier (W/O), Penetration Enhancer, Solvent, Stabilizer, Viscosity Modifier

CAS Number: 142-55-2, 199282-83-2, 27194-74-7, 37321-62-3

Dosage Form: Capsules, Soft Gels, Tablets

Ingredient Origin: Natural Origin, Non-Animal Origin, Plant Origin, Vegetable Origin

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Knowde Enhanced TDS

Identification & Functionality

Chemical Family
Pharma & Nutraceuticals Functions
CAS No.
27194-74-7, 142-55-2, 199282-83-2, 37321-62-3
EC No.
248-315-4, 205-542-3

Features & Benefits

Product Highlights

Processing Aids

  • Direct-compression, free-fraction tablet lubricants which reduce ejection force but allow for faster disintegration times than surface spreading lubricants
  • Soft gel lubricants which allow for less washing and ease of capsule printing
  • Binder excipients for hot melt granulation and extrusion

Emulsification

  • Functional lipids for primary and secondary emulsification of actives
  • Emulsifiers and surfactants for the formulation of self-emulsifying drug delivery systems (SEDDS)

Lipid Nanoparticle Delivery Systems

  • Functional lipids for the development of solid lipid nanoparticles and nanostructured lipids

Permeation Enhancement

  • Functional lipids which can increase the permeation of BCS Class III and BCS Class IV actives
  • Increase permeation of polar molecules with functional groups which are ionized at biological pH
  • Increase permeation of actives affected by PGP mediated efflux

Controlled Release

  • Formulation of both matrix and encapsulated controlled release
  • Formulation of controlled release multi-particulates for use in tablet and capsule formulations
  • Directly-compressed matrix controlled release tablet formulations

Encapsulation

  • Formulation of functional multi-particulates
  • Use in both matrix and encapsulated multi-particulates
  • Employ in both congealing and molten fluid bed unit operations

Applications & Uses

Application Format
Applications
  • Emulsification
  • Transdermal Penetration Enhancer

Properties

Physical Form
Typical Properties
ValueUnitsTest Method / Conditions
CBD Solubility (Visual)10%w/w
Solubilization
  • Increase the solubility of BCS Class II and BCS Class IV actives
  • Increase the bioavailability of poorly water-soluble actives
  • Both single lipid and self-emulsifying drug delivery system (SEDDS) formulations of poorly water soluble APIs

Regulatory & Compliance

Regulatory Status

USP/NF, FCC, USFA, JSFA, E477