Knowde Enhanced TDS
Identification & Functionality
- Chemical Family
- INCI Name
- Ingredient Origin
- Cosmetic Ingredients Functions
- CAS No.
- 121-54-0
- EC No.
- 204-479-9
- Technologies
- Product Families
Features & Benefits
- Benefit Claims
- Key Attributes
- Strong antibacterial
- Not sensitizing
- Cationic antimicrobial
- Has a wide range of global regulatory acceptance
- Water soluble
- Light in color
- Odorless
- Can be used in a variety of personal care applications
Applications & Uses
- Markets
- Applications
- AP/Deo Applications
- Baby Care Applications
- Bath & Shower Applications
- Color Cosmetic Applications
- Hair Care Applications
- Personal Hygiene Applications
- Skin Care Applications
- Sun Care Applications
- Wipes, Tissue & Towel Applications
- Use Level
- 0.1 – 0.5 %
- Application pH Range
- 6–9
- Applications
- Baby care
- Baby wipes
- Body wash
- Conditioner
- Cream
- Deo/ Anti-perspirant
- Eye creams/gels
- Eye shadow
- Face lotion
- Face wipes
- Facial cream
- Feminine hygiene
- Foundation
- Hand soap (non anti-bac)
- Lipstick/gloss
- Lotion
- Make up remover
- Mascara
- Oil in Water
- Oral care (as preservative, not the active)
- Powder
- Shampoo
- Suncare
- Toner
- Water in Oil
- Formulation Recommendations
- Soluble in water, lower alcohols and glycols
- Compatible with a wide variety of formulations as well as most types of cationic and non-ionic systems
- It can be used effectively over a particularly wide pH range
- Can be added at both room and elevated temperatures in any phase of production
Properties
- Odor
- Odorless
- Soluble in
- Water
Regulatory & Compliance
- Certifications & Compliance
- Chemical Inventories
- Global Regulatory
Europe
- Benzethonium chloride is approved, Annex V to Regulation EC/1223/2009
- Max concentration of 0.1 %; not permitted for oral care
Japan
- Japan = 0.5 % for rinse-off; 0.2 % for leave-on
- Not permitted for contact with mucous membranes (eye, oral care, vaginal, etc.)
US
- U.S. (CIR opinion)
- 0.5 % for skin applications
- 0.02 % for eye area
Technical Details & Test Data
- Efficacy
MICs were conducted on Lonzagard® Benzethonium Chloride USP for both bactericidal and bacteriostatic activity with results following.
MICs
Organism MIC (ppm) Streptococcus pyogenes C-203 20 Streptococcus viridans 3 Escherichia coli 63 Salmonella gallinarum 31 Salmonella choleraesuis 31 Salmonella typhimurium 5 Salmonella schottmulleri 31 Pseudomonas aeruginosa PRD-10 125 Lactobacillus casei 10 Shigella sonnei 31 Klebsiella pheumoniae 5 Saccharomyces cerevisiae 10 Pityrosporumovale 1 Trichophyton mentagrophytes 25 Monilia albicans 1 Aspergillus niger 1250 Aspergillus oryzae 0.625 Penicillium notatum 1 Penicillium luteum 1 - Microbiological Challenge Studies
A study was run on a formula using a 0.5% concentration of Lonzagard® Benzethonium Chloride USP. The protocol used was a PCPC challenge test. All samples were inoculated at the beginning of the study, sampled at 24 hours, 7, 14, 21 and 28 days. The samples were diluted in neutralizer and plated quantitatively for viable organisms at all sampling times. After 28 days, all samples were re-inoculated and subjected to a second challenge.
- Lotion
pH: 5–5.5
Phase (A) % Phase (B) % Water qs Hydroxyethylcellulose 1.5 Urea 5.00 - - Sorbitan Monostearate 2.00 - - Caprylic/ Capric Triglyceride 20.00 - - PEG 1750 Monostearate 1.50 - - Glyceryl Monostearate 2.00 - - Decaglycerol Decaoleate 5.00 - - - Test Results
Test Organism Unpreserved Control Test – Lonzagard® Benzethonium Chloride USP (0.5%) Initial Challenge Re challenge Initial Challenge Re challenge 24 Hrs 1 Week 28 Days 28 Days 24 Hrs 1 Week 28 Days 28 Days S. aureus 2.0 x 10^6 1.4 x 10^6 1.0 x 10^2 8.3x 10^2 <10 <10 <10 <10 K. pneumoniae + E. gergoviae 1.1 x 10^6 3.0 x 10^4 <10 <10 <10 <10 <10 <10 P. aeruginosa + B. cepacia 1.0 x 10^5 1.5 x 10^3 <10 3.0 x 10^5 <10 <10 <10 <10 C. albicans 6.9 x 10^4 3.0 x 10^1 <10 <10 <10 <10 <10 <10 Mixed Molds 5.8 x 10^4 3.2 x 10^4 1.5 x 10^4 2.5 x 10^4 1.0 x 10^2 1.0 x 10^1 <10 1.0 x 10^1
Packaging & Availability
- Country Availability
- Regional Availability