Knowde Enhanced TDS
Identification & Functionality
- INCI Name
- Ingredient Origin
- Cosmetic Ingredients Functions
- CAS No.
- 32289-58-0, 133029-32-0, 28757-47-3, 70170-61-5
- Technologies
- Product Families
- Compositional Breakdown
Chemical Compound Breakdown CAS No. EINECS Water 7732-18-5 231-791-2 Polyaminopropyl Biguanide 133029-32-0 / 27083-27-8 Chemical Compound Breakdown % Water 79.0–81.0% Polyaminopropyl Biguanide 19.0–21.0%
Features & Benefits
- Benefit Claims
- Labeling Claims
- Key Attributes
- Fast-Acting and Trusted Antibacterial
- Clear, colorless, highly water-soluble
- Fast-acting and strong antibacterial efficacy
- High activity vs. tough Gram (negative) organisms e.g. Pseudomonas
- Chemically stable and non-volatile
- Zero VOC
- Effective and stable over a broad pH range (3-10)
- UV stable
- Odorless and non-foaming
- Broad global acceptance
- Non-sticky feel on the skin
Applications & Uses
- Markets
- Applications
- AP/Deo Applications
- Baby Care Applications
- Bath & Shower Applications
- Color Cosmetic Applications
- Hair Care Applications
- Personal Hygiene Applications
- Skin Care Applications
- Sun Care Applications
- Wipes, Tissue & Towel Applications
- Use Level
- 0.2-1.5%
- Application pH Range
- 3–10
- Applications
- Baby care
- Baby wipes
- Body wash
- Conditioner
- Cream
- Deo/ Anti-perspirant
- Eye creams/gels
- Eye shadow
- Face lotion
- Face wipes
- Facial cream
- Foundation
- Hair gel
- Hand soap (non anti-bac)
- Lipstick/gloss
- Lotion
- Make-up remover
- Mascara
- Oil in Water
- Oral care (as preservative, not the active)
- Powder
- Shampoo
- Suncare
- Toner
- Water in Oil
- Formulation Recommendations
- If additional antifungal activity is required, Cosmocil® CQ can be
formulated alongside the likes of sorbic acid, benzoic acid or IPBC - Since the active agent PHMB is cationic, the compatibiility and
efficacy in anionic systems may be impacted
- If additional antifungal activity is required, Cosmocil® CQ can be
Properties
- Odor
- Odorless
- Appearance
- Clear
- Soluble in
- Water
Regulatory & Compliance
- Certifications & Compliance
- Chemical Inventories
- Global Regulatory
Europe
- Polyaminopropyl biguanide is listed on the Annex V to Regulation
EC/1223/2009 – formerly Annex VI to Council Directive 76/768/EEC
relating to preservatives for use in cosmetic products - Max authorized use level of 0.1% PHMB as a preservative
Japan
- Approved for all categories of cosmetic products (leave-on, rinse-off
and mucous contact) at a maximum dosage of 0.1% PHMB
United States
- Allowed for Personal Care Products
- Polyaminopropyl biguanide is listed on the Annex V to Regulation
Technical Details & Test Data
- Efficacy
Microbiological Challenge Studies
Studies were run on three formulas at two concentrations of Cosmocil® CQ. The protocols used were the CTFA challenge test (56-day study with reinoculation at Day 28) and the EP challenge test (28-day).
- Make-Up Remover Formulation
Ingredient Identity % (w/w) Propylene Glycol Propylene Glycol 2.0 Glycerin Glycerin 2.0 PEG-8 Monooleate PEG-8 Monooleate 2.0 Plantaren 2000 N UP Decyl Glucoside 25.0 Cosmocil® CQ Polyaminopropyl biguanide 0.50 DI water Water To 100% pH 5.5 – 56-day CTFA protocol : 0.5% Cosmocil® CQ
Challenge 1 Challenge 2 Test Organism CFU/g counts 24 hours 7 days 28 days 24 hours 7 days 28 days Staphylococcus aureus <10 <10 <10 <10 <10 <10 Pseudomonas aeruginosa + Burkholderia cepacia 4.5 x 10^3 <10 <10 3.0 x 10^4 <10 <10 Klebsiella pneumoniae + Enterobacter gergoviae <10 <10 <10 <10 <10 <10 Candida albicans 6.9 x 10^3 2.0 x 10^1 <10 9.0 x 10^1 <10 <10 Aspergillus brasiliensis + Penicillium sp 9.8 x 10^3 2.7 x 10^3 <10 3.2 x 10^2 4.0 x 10^1 4.0 x 10^2 pH 7.8 – 56-day CTFA protocol : 0.5% Cosmocil® CQ
Challenge 1 Challenge 2 Test Organism CFU/g counts 24 hours 7 days 28 days 24 hours 7 days 28 days Staphylococcus aureus <10 <10 <10 <10 <10 <10 Pseudomonas aeruginosa + Burkholderia cepacia <10 1.0 x 102 <10 <10 <10 <10 Klebsiella pneumoniae + Enterobacter gergoviae <10 <10 <10 <10 <10 <10 Candida albicans <10 <10 <10 <10 <10 <10 Aspergillus brasiliensis + Penicillium sp 4.0 x 103 3.0 x 103 2.4 x 102 3.1 x 102 1.1 x 102 2.1 x 103 56-day CTFA protocol : Unpreserved control
Challenge 1 Challenge 2 Test Organism CFU/g counts 0 hours 24 hours 7 days 28 days 0 hours 24 hours 7 days 28 days Staphylococcus aureus 4.5 x 10^4 <10 <10 <10 1.4 x 10^6 2.0 x 10 <10 <10 Pseudomonas aeruginosa + Burkholderia cepacia 3.6 x 10^6 1.3 x 10^5 2.1 x 10^6 1.2 x 10^7 9.1 x 10^6 4.2 x 10^6 9.2 x 10^6 2.3 x 10^6 Klebsiella pneumoniae + Enterobacter gergoviae 1.2 x 10^6 7.0 x 10^3 5.0 x 10^4 8.5 x 10^5 3.8 x 10^6 2.1 x 10^6 2.2 x 10^6 <10 Candida albicans 8.7 x 10^4 6.3 x 10^4 1.6 x 10^4 1.7 x 10^4 2.0 x 10^3 1.5 x 10^3 1.2 x 10^2 <10 Aspergillus brasiliensis + Penicillium sp 5.5 x 10^4 5.1 x 10^4 1.6 x 10^4 1.7 x 10^4 5.4 x 10^4 8.8 x 10^4 4.0 x 10^4 2.1 x 10^4 - Skin Cleanser
Ingredient Identity % (w/w) Disodium EDTA Disodium EDTA 0.1 Butylene glycol Butylene glycol 3.0 Glycerin Glycerin 4.0 Natrulon® H-6 Polyglycerin-6 5.0 Deionized water Water 82.74 – Foeniculum vulgare (Fennel) Seed Extract 1.0 NAB® Butterbur Extract Petasites japonicus Root Extract 1.0 Polyaldo® 10-1-CC Polyglyceryl-10 Caprylate/Caprate 3.0 Sodium hydroxide (10% solution) to pH 6.7 - 0.16 pH 6.7 – 28-day EP protocol : 0.4% Cosmocil® CQ
Test Organism CFU/g counts 0 days 2 days 7 days 14 days 28 days EP Pass Criteria Pseudomonas aeruginosa 3.60 x 10^6 <10 <10 NT <10 A Staphylococcus aureus 4.30 x 10^6 <10 <10 NT <10 A Candida albicans 1.70 x 10^5 NT NT <10 <10 A Aspergillus brasiliensis 2.60 x 10^5 NT NT 1.20 x 10^3 <10 A NT = Not Tested
28-day EP protocol : Unpreserved control
Test Organism CFU/g counts 0 days 2 days 7 days 14 days 28 days EP Pass Criteria Pseudomonas aeruginosa 1.90 x 10^6 3.40 x 10^6 3.80 x 10^6 NT NT Fail Staphylococcus aureus 2.20 x 10^6 1.36 x 10^5 2.90 x 10^4 NT NT Fail Candida albicans 1.65 x 10^5 NT NT NT NT Fail Aspergillus brasiliensis 2.30 x 10^5 NT NT NT NT Fail - Lotion
Ingredient Identity % (w/w) Urea Urea 5.00 Sorbitan Monostearate Sorbitan Monostearate 2.00 Aldo® MCT Caprylic/Capric Triglyceride 20.00 PEG-1750 Monostearate PEG-1750 Monostearate 1.50 Lonzest® MSA Glyceryl Monostearate 2.00 Polyaldo® 10-10-O Decaglycerol Decaoleate 5.00 Natrosol 250HHR Hydroxyethylcellulose 0.75 Cosmocil® CQ Polyaminopropyl biguanide 0.50 DI water Water To 100% Test Results
pH 5.4 – 56-day CTFA protocol : 0.5% Cosmocil® CQ
Challenge 1 Challenge 2 Test Organism CFU/g counts 24 hours 7 days 28 days 24 hours 7 days 28 days Staphylococcus aureus <10 <10 <10 <10 <10 <10 Pseudomonas aeruginosa + Burkholderia cepacia 9.0 x 10^2 7.0 x 10^2 <10 <10 <10 <10 Klebsiella pneumoniae + Enterobacter gergoviae 7.0 x 10^2 3.0 x 10^2 <10 <10 <10 <10 Candida albicans <10 <10 <10 <10 <10 <10 Aspergillus brasiliensis + Penicillium sp 5.0 x 10^2 5.0 x 10^2 1.8 x 10^2 2 6.0 x 10^1 <10 1.9 x 10^2 pH 7.6 – 56-day CTFA protocol : 0.5% Cosmocil® CQ
Challenge 1 Challenge 2 Test Organism CFU/g counts 24 hours 7 days 28 days 24 hours 7 days 28 days Staphylococcus aureus 5.0 x 10^2 3.0 x 10^2 <10 <10 <10 <10 Pseudomonas aeruginosa + Burkholderia cepacia <10 <10 <10 <10 <10 <10 Klebsiella pneumoniae + Enterobacter gergoviae <10 <10 <10 <10 <10 <10 Candida albicans <10 <10 <10 <10 <10 <10 Aspergillus brasiliensis + Penicillium sp 1.1 x 10^4 8.0 x 10^2 4.0 x 10^1 2.3 x 10^4 5.0 x 10^1 <10 56-day CTFA protocol : Unpreserved control
Challenge 1 Challenge 2 Test Organism CFU/g counts 0 hours 24 hours 7 days 28 days 0 hours 24 hours 7 days 28 days Staphylococcus aureus 3.3 x 10^6 2.2 x 10^6 7.7 x 10^5 <10 3.2 x 10^6 4.0 x 10^6 1.5 x 10^6 1.0 x 10^1 Pseudomonas aeruginosa + Burkholderia cepacia 1.2 x 10^6 3.9 x 10^5 3.4 x 10^4 <10 3.1 x 10^6 1.4 x 10^6 4.9 x 10^4 1.5 x 10^4 Klebsiella pneumoniae + Enterobacter gergoviae 3.8 x 10^6 8.3 x 10^5 1.5 x 10^4 <10 7.4 x 10^6 2.0 x 10^6 1.5 x 10^4 <10 Candida albicans 1.1 x 10^5 1.1 x 10^5 1.4 x 10^3 2.1 x 10^1 2.0 x 10^3 7.6 x 10^2 <10 <10 Aspergillus brasiliensis + Penicillium sp 6.0 x 10^4 8.0 x 10^4 8.0 x 10^4 1.9 x 10^4 6.4 x 104 6.7 x 10^4 <10 <10
Packaging & Availability
- Country Availability
- Regional Availability