Various research studies, including seven human clinical trials, support the safety, efficacy, and bioavailability of BioCell Collagen®.
Toxicology/Safety Studies
The in vitro, animal and human studies conducted on BioCell Collagen, as well as the extensive historical consumption of BioCell Collagen in dietary supplements since 1998, demonstrate a good safety profile. BioCell Collagen safety data was reviewed by an Expert Panel of toxicology scientists who determined through scientific procedures that the intended uses of BioCell Collagen as a dietary ingredient are Generally Recognized as Safe (GRAS). Furthermore, a study was published in Food and Chemical Toxicology in 2007.
BioCell Collagen® Human Bioavailability Study
Hyaluronic Acid (HA) is in virtually all tissues of the body. In the joint, HA plays two essential roles. First, it acts as a key structural molecule to form healthy, functional cartilage. Second, HA is a major component of synovial fluid, the lubricant found in our joints that allows smooth and easy movement. In a 28-day bioavailability study in humans showed that ingestion of BioCell Collagen® (1500 mg/day) led to a 60 times increase in HA levels at steady state.
Multiple Human Clinical Trials
Multiple human clinical trials demonstrate the safety and efficacy of BioCell Collagen® in promoting joint and skin health.
BioCell Collagen® Joint Support Studies
In an 80 subject, randomized, double-blind, placebo-controlled trial for joint health, investigators tested the tolerability and efficacy of BioCell Collagen® supplementation. The participants were divided into two groups and administered either 2 g of BioCell Collagen or placebo for 70 days. Compared to placebo, the BioCell group had a significant reduction of joint discomfort on days 35 (p = 0.017) and 70 (p < 0.001). Furthermore, the BioCell group experienced a significant improvement in physical activities compared to the placebo group on days 35 (p = 0.007) and 70 (p < 0.001). BioCell Collagen was well tolerated and found to be effective, thereby improving mobility and quality of life. The peer-reviewed study was published in the Journal of Agriculture and Food Chemistry. (Schauss et al., 2012).
These results were similar to the results of another earlier double-blind placebo-controlled trial tested on sixteen people. (Kalman et al., 2004).
BioCell Collagen® Skin Beauty-from-Within Studies
1. In a 12-week study, women who took 1000 mg of BioCell Collagen daily had 76% less dryness/scaling, and their fine lines and wrinkles had reduced by 13.2% when compared to baseline levels. Additionally, both collagen levels and microcirculation were significantly improved. The outcome of this study was published in the Clinical Interventions in Aging journal (Schwartz, Park J, 2012).
2. In one of the most substantial studies of a skin health supplement, 1000 mg of BioCell Collagen® was found to visibly reduce common signs of skin aging, including lines and wrinkles, within 12 weeks of daily use. The findings reported in this randomized, double-blind, placebo-controlled clinical trial included a measurable improvement in signs of aging in women, represented by increased skin elasticity, reduction of crow's feet, and improvement in depth and number of fine lines and wrinkles. The full findings of the peer-reviewed study are published in the journal of Alternative Therapies in Health and Medicine. (Schwartz, Hammon KA, 2019).