Knowde Enhanced TDS
Identification & Functionality
- Ingredient Origin
- Cosmetic Ingredients Functions
- Technologies
- Product Families
Features & Benefits
- Labeling Claims
Applications & Uses
- Markets
- Applications
- Skin Care Applications
- Use Level
- 3-5%
- Application pH Range
- 4.5-6.5
- Mode of Action
Based on a synergistic combination of extracts of Hieracium pilosella and Bellis perennis flowers, JuvenEye CLR addresses the most important aspects in the formation and maintenance of dark circles and puffy eyes. JuvenEye CLR induces the production of heme oxygenase and VEGF-C, activates autophagy and increases cellular functionality and energy. It also acts on melanin deposition. The appearance of dark circles, their color and surface area are reduced.
- Recommended Uses
JuvenEye CLR is recommended for being used in face care products, particularly eye care applications. It counteracts dark circles and puffy eyes.
- Formulation Guidelines
Can be used in emulsified and gel type formulations or serums. Short heating to 40 °C (maximum) does not affect the activity. The pH of formulations containing JuvenEye CLR should be in the range 4.5 to 6.5.
Properties
- Physical Form
- Odor
- Characteristic
- Appearance
- Translucent cognac colored liquid
- Soluble in
- Water
Regulatory & Compliance
- Certifications & Compliance
Safety & Health
- Physiological Safety
Acute oral toxicity
Both, Hieracium pilosella (aerial parts) and Bellis perennis flowers have a long tradition in plant medicine and are used, for example, as herbal tea. Hence there is no need for testing the acute oral toxicity.
Eye irritation potential
JuvenEye CLR (undiluted) was tested on the chorioallantoic membrane of the hen's egg. The calculated mean irritation score was 0. JuvenEye CLR therefore was classified as "non-irritant" to mucous membranes.
Skin compatibility
A 48 hour Patch test with a 50% solution of JuvenEye CLR has been performed on a panel of 50 volunteers (18-70 years; 28 normal healthy, 5 eczema, 4 allergy and 13 subjects with sensitive skin). All participants completed the study. Under the test conditions, SDS (1% in water) caused positive reactions in 19 subjects. The negative control water showed no reactions. None of the subjects showed any reaction to the test product. On the basis of these test results and under the test conditions, the product "JuvenEye CLR" is to be classified as 'harmless' with regard to the possibility of skin irritation.
Mutagenicity
JuvenEye CLR was investigated for its potential to induce gene mutations according the bacterial reverse mutation assay using 4 different strains of Salmonella typhimurium and E. coli WP2 uvrA bacteria, with and without metabolic activation. No mutagenic effects could be observed in any of the five tester strains up to the highest dosage.
Phototoxicity
JuvenEye CLR has been tested in vitro using the 3T3 Neutral Red Uptake Phototoxicity Assay. No phototoxic effects have been observed up to the highest dosage in this assay.
Packaging & Availability
- Packaging Information
Available pack sizes: 1 kg; 5 kg; 25 kg
Sample size: 50 g
Storage & Handling
- Storage and Handling
If kept at a temperature between 10 °C and 20 °C in well-closed containers, JuvenEye CLR is stable for at least 1 year. Product packs should be fully used once opened.
- Preservative System
Sodium benzoate and Sodium dehydroacetate