Knowde Enhanced TDS
Identification & Functionality
- INCI Name
- Ingredient Origin
- Cosmetic Ingredients Functions
- CAS No.
- 84082-51-9
- EC No.
- 281-998-7
- Technologies
Features & Benefits
- Benefit Claims
- Labeling Claims
Applications & Uses
- Markets
- Color Cosmetic Applications
- Skin Care Applications
- Use Level
- approx. 0.5%
- Mode Of Action
Skin aging can be explained by diminishing cell functions in dermis and epidermis. The Extra Cellular Matrix (ECM), a highly organized dermal tissue, is responsible for the mechanical properties of the skin. Modifications of the dermal structure due to decreasing activity of the fibroblasts lead to loss of elasticity and formation of wrinkles
MPC - a carrier of active milk endogenous cell regulators - stimulates the regenerative cell functions. In cell cultures the following activities of MPC are detectable:
- Stimulation of protein synthesis - especially synthesis of Collagen type I
- Recovery of ECM
- Activation of cell metabolism
The in vitro results of MPC could be verified in various human tests with different cosmetic formulations. Formulations containing MPC in recommended dosages counteract the aging symptoms of the skin by influencing the following parameters:
- Smoothing effect on the skin and reduction of wrinkle depth
- Improvement of skin elasticity
- Increase in skin thickness
- Recovery of the dermal structure in case of cellulite
Thus MPC helps the skin to restore its functions and appearance in relation to its respective age.
- Processing
Short heating of MPC solution to approx. 40 °C does not affect its activity. Alkaline pH values in formulations should be avoided. MPC does not contain any preservatives.
Properties
- Odor
- Almost odorless
- Soluble in
- 1% lactic acid or other acids at pH 3
Regulatory & Compliance
Technical Details & Test Data
- Solubility
Depending on the dosage, MPC yields turbid suspensions in water. Due to their isoelectric points, some of the milk proteins present in MPC do not dissolve in either water or aqueous buffer solutions within a pH range from 4.0 to 6.0. Acid buffer solutions improve the solubility of MPC.
At a pH of approx. 3.0 MPC almost completely dissolves, e. g. 1 % lactic acid or other acids can be used. The same solubility applies to pH values ranging from 6.0 to 7.0, e. g. in di-NaCitrate/NaOH buffer according to Soerensen (0.1 mol di-Na-Citrate + 0.1 mol NaOH; mixed 1:1, pH approx. 6.6).
Safety & Health
- Physiological Safety
Acute oral toxicity
LD50 oral: min. 2000 mg/kg body weight (rat).
No toxicologically significant effects were observed.
Eye Irritation Test
As alternative to the classic Draize test on rabbit eyes the in vitro test EytexTM was used. According to Eytex MPC (2.5 %) was classified to be "mild" to eyes. The prediction for in vivo tests corresponds to: minimal. It can, therefore, be applied to the area around the eye without hesitation.
Skin compatibility
In a patch test on 30 volunteers a gel with 0.5 % MPC produced no erythema, scaling or fissure formation. According to this result MPC was classified as "harmless" as regards the possibility of skin irritation.
MPC was applied to various human tests under use conditions in recommended dosages. The dermatological results confirmed that no indication as to any potential skin incompatibility could be observed.
Mutagenicity
According to Ames MPC showed no mutagenic effect on 5 strains of Salmonella typhimurium.
Packaging & Availability
- Packaging Information
- Available pack sizes: 0.1 kg, 0.5 kg, 1 kg, 5 kg
- Sample size: 5 g
Storage & Handling
- Storage and Handling
Protect from light; store in tightly sealed containers, storage temperature between 15-25°C . MPC has a shelf life of at least 2 years.