Knowde Enhanced TDS
Identification & Functionality
- Carrier
- Ingredient Origin
- Cosmetic Ingredients Functions
- Technologies
Features & Benefits
- Benefit Claims
Applications & Uses
- Markets
- Hair Care Applications
- Skin Care Applications
- Sun Care Applications
- Use Level
- 3%
- Mode of Action
MultiMoist CLR, a multi-potent natural based moisturizer, helps to easily develop moisturizing formulations required by modern consumers. It contains hygroscopic molecules originating from short chain fructooligosaccharides (scFOS) and the root of Beta vulgaris. scFOS can all be naturally found in numerous fruit and vegetables. When applied onto the skin these molecules immediately raise the hydration level in the SC, making the skin smoother and more supple, and ensuring a healthy appearance.
Using different tools like MoistureMap, Moisture Accumulation Test (MAT), Squametry and Corneometry, the superior performance of MultiMoist CLR has been proven in vivo.
Furthermore it has been demonstrated that MultiMoist CLR is capable of stimulating the expression of the Vitamin D Receptor (VDR). As more and more moisturizing day care concepts are formulated with sunscreens, contribution to unwanted Vitamin D deficiency is becoming an issue, especially in shorter daylight hours. Stimulating the expression of VDR therefore can be strategy to counteract this unwanted phenomenon.
On the other hand, an increase in expression of the VDR leads to an improvement of epidermal differentiation, which strengthens the barrier function and therefore leads to more moisturized skin.
- Recommended Uses
MultiMoist CLR is intended for applications for every day care cosmetics and cosmetics for dry skin. It can be used in emulsified, aqueous and aqueous-alcoholic skin moisturizing cosmetics. Biophysical investigations also support the use of MultiMoist CLR in hair care formulations.
- Formulation Guidelines
MultiMoist CLR is relatively thermostable and may be heated briefly to the temperatures required for the manufacture of emulsified preparations. During manufacturing of emulsified preparations MultiMoist CLR is dissolved in the water phase. In the manufacture of aqueous-alcoholic preparations MultiMoist CLR is added to the alcoholwater mixture. MultiMoist CLR does not affect the color of cosmetics.
Properties
- Physical Form
- Odor
- Weak specific
Regulatory & Compliance
Technical Details & Test Data
- Solubility
Soluble in water and water-alcohol mixtures with an alcohol concentration not exceeding 50% w/w
Safety & Health
- Physiological Safety
Acute oral toxicity
MultiMoist CLR is based on ingredients, which have a long tradition in food. MultiMoist CLR is considered to be non-toxic and safe in cosmetic use at the levels advised by us.
Eye irritation potential
MultiMoist CLR being tested at a concentration of 50 % using the EpiOcular Eye Irritation Test (EIT) was classified as "non-irritant". MultiMoist CLR was tested at a concentration of 50 % using the Bovine Corneal Opacity and Permeability Assay (BCOP). The calculated mean in vitro irritation score was: - 0.06. According to the evaluation criteria MultiMoist CLR is classified into UN GHS “No Category”.
Skin compatibility
A 48 hour Patch test with a 10% containing MultiMoist CLR formulation has been performed on a panel of 50 volunteers (18-69 years; 28 with normal healthy skin, 3 with eczema, 4 allergic and 15 subjects with sensitive skin). All participants completed the study. Under the test conditions, SDS (1% in water) caused positive reactions in 16 subjects. The negative control water showed no reactions. None of the subjects showed any reaction to the test product. On the basis of these test results and under the test conditions, the product "MultiMoist CLR" is to be classified as 'harmless' with regard to the possibility of skin irritation.
Sensitization
Human Repeated Insult Patch Test (HRIPT): MultiMoist CLR was tested on 50 volunteers (repeated application) using a 50% solution of the active in preserved water. The study was conducted in a double-blinded fashion with female/male subjects between 16 and 65 years old participating. Applications were repeated 9 times over a period of three consecutive weeks. Concerning the allergenic potential of the investigated product MultiMoist CLR, no subject presented a positive allergic reaction according to the allergenicity evaluation scale established by the ICDRG (International Contact Dermatitis Research Group) in the test condition.
Mutagenicity
MultiMoist CLR was investigated for its potential to induce gene mutations according the bacterial reverse mutation assay using 4 different strains of Salmonella typhimurium and E. coli WP2 uvrA bacteria, with and without metabolic activation. No mutagenic effects could be observed in any of the five tester strains up to the highest dosage.
Phototoxicity
MultiMoist CLR has been tested in vitro using the 3T3 Neutral Red Uptake Phototoxicity Assay. No phototoxic effects have been observed up to the highest dosage in this assay.