Knowde Enhanced TDS
Identification & Functionality
- INCI Name
- Ingredient Origin
- Cosmetic Ingredients Functions
- Technologies
Features & Benefits
Applications & Uses
- Markets
- Color Cosmetic Applications
- Skin Care Applications
- Use Level
- 2 - 5 %
- Application pH Range
- 3.0 – 7.5
- Mode of Action
- Cell-cell communication is essential for all functions of the human body. Via cell receptors and appropriate signaling molecules metabolic and catabolic reactions can be controlled in the cell. Environmental influences such as UV light interfere with metabolic processes in human skin by modulating signaling pathways between the cells. Cell receptors not only recognize endogenous signaling molecules; defined classes of substances derived from plants are also able to influence cell responses by interacting with cell receptors.
- By both in vitro experiments conducted with human skin cells and in vivo tests on humans it could be demonstrated that the ingredients of Phytosan K can influence cell responses. The biological activity of Phytosan K shows in a significant increase in total protein synthesis as a result of signal transduction as well as in an induction of collagen biosynthesis.
- Apart from a resultant improvement of the microrelief of the skin, Phytosan K was found to have extraordinary anti-stress activity after UV irradiation. Phytosan K clearly prevents decrease in ATP levels in keratinocytes after UV exposure, thus enabling cell mechanisms for prevention of DNA damage to produce a more efficient protective effect.
- Phytosan K significantly increases the DNA repair rate after UV exposure, with resultant decrease in the number of reparable DNA single strand breaks and less irreparable DNA damage. Furthermore, formation of sunburn cells is reduced by modulation of UV-induced apoptosis.
- By interfering with protective mechanisms of skin cells, Phytosan K possesses a high photoprotective potential. As a "biological sun protection factor" Phytosan K thus counteracts UV-induced premature skin aging. Since it simultaneously stimulates skin regenerative cell functions, it improves skin elasticity and the microrelief of the skin.
- Recommended Uses
Phytosan K is suitable for the regenerative skin care and for the care of stressed skin. It especially counteracts UV-induced premature skin aging.
It can be u sed in emulsified and gel-type skin care products. Use of emulsifiers and/or gel builders which are non-sensitive to electrolytes is recommended.
- Processing
When formulating Phytosan K it must be noted that electrolyte sensitive raw materials of formulations might be influenced. Small amounts of EDTA can stabilize the emulsion. Ionic emulsifiers should not be used. Electrolyte sensitive rheology modifiers and hydrocolloids might lose some efficacy when Phytosan K is added. This impact can be overcome when EDTA is added (1/10 of the used Phytosan K quantity). The development of W/O formulations is possible without any difficulties. The temperature should not exceed 40 °C during the production process, precipitations could be observed in the case of higher temperatures. The pH range of formulations with Phytosan K is wide and allows formulations between 3.0 – 7.5.
Properties
- Physical Form
- Odor
- Characteristic
- Appearance
- Transparent liquid
- Soluble in
- Water
Regulatory & Compliance
- Certifications & Compliance
Safety & Health
- Physiological Safety
Acute oral toxicity
Phytosan K is made from food grade, non-genetically modified soybeans. Since the
manufacturing procedure does not chemically alter the raw material and no toxic substances are used to produce Phytosan K, oral toxicity testing in the rat was not conducted with this product. Phytosan K is considered to be non-toxic.Eye irritation potential
The eye irritancy potential of Phytosan K was tested in the chorioallantoic membrane at a 100 % concentration using an alternative preservation (parabens) under the product name "Phytosan". Phytosan, undiluted, was classified as non-irritant.
Human Repeated Insult Patch Test (HRIPT according to Shelanski):
An O/W cream containing 10 % Phytosan (preserved with parabens) was applied repeatedly to 50 volunteers with dry, sensitive skin (among them, 9 persons suffering from eczemas) for a duration of 4 weeks. The cream containing Phytosan did not produce any skin irritating effects nor signs of skin sensitization.
Phototoxicity
Phytosan (undiluted) has been tested in vitro using the 3T3 Neutral Red Uptake Phototoxicity Assay. No phototoxic effects have been observed.
Packaging & Availability
- Packaging
Available pack sizes: 1 kg, 5 kg, 25 kg
Sample size: 50 g
Storage & Handling
- Storage And Handling
If kept at 10 - 20 °C, protected from frost and light, in well-closed containers, Phytosan K is stable for at least 2 years. Product packs should be fully used once opened.
- Preservative System
Phenoxyethanol and potassium sorbate