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Contipro Clodessine

Clodessine is an active fragment of anti-aging circulating factor Klotho. Giving Klotho to the skin cells has true rejuvenation effect that reduces wrinkle depth and makes skin more healthy and smooth, increases skin elasticity, protects against premature aging caused by everyday stress.

INCI Name: Phenoxyethanol, Phosphate Buffered Saline, sh-Nonapeptide-4

Functions: Anti-Aging Agent, Anti-Wrinkle Agent

Benefit Claims: Anti-Aging, Anti-Pollution, Anti-Wrinkle, DNA Protection, Free Radical Scavenging, Improved Texture, Improves Skin Elasticity, Pore Reduction, Protection From Environmental Damage, Repairing, Wrinkle Refinement

Technical Data Sheet
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Knowde Enhanced TDS

Identification & Functionality

INCI Name

Phenoxyethanol,

Phosphate Buffered Saline,

sh-Nonapeptide-4

Cosmetic Ingredients Functions

Anti-Aging Agent,

Anti-Wrinkle Agent

Technologies

Cosmetic Ingredients

Product Families

Cosmetic Ingredients — Cosmetic Actives

Skin Actives

Features & Benefits

Benefit Claims

Anti-Aging,

Anti-Pollution,

Anti-Wrinkle,

DNA Protection,

Free Radical Scavenging,

Improved Texture,

Improves Skin Elasticity,

Pore Reduction,

Protection From Environmental Damage,

Repairing,

Wrinkle Refinement

Additional Advantages of Clodessine
  • Protects against premature aging caused by everyday stress
  • Prolong lifespan of the cells
  • Activate natural defensive mechanisms in the cells
  • Protect skin cells against evironmental stress factors, pollutants and free radicals
  • Help to make DNA repair mechanisms in the skin cells more effective

Applications & Uses

Markets

Personal Care

Applications

Personal Care — Beauty & Care

Skin Care

Application Format

Creams,

Lotions,

Masks,

Serum

Recommended Concentration in Final Product

0.01 - 1% of solution.

Compatibility and Processing

Sensitive to heat, Sensitive to extreme pH, Recommended pH 5.5 - 8

Properties

Physical Form

Liquid,

Solution

Insoluble in
Non-water miscible solvents
Soluble in
Water
Physico-Chemical Properties
ValueUnitsTest Method / Conditions
PreservativePhenoxyethanol/Phenethylalcohol——

Technical Details & Test Data

In Vivo Study by Contipro

Wrinkle Reduction : 52% Reduction Of Wrinkles

Contipro Clodessine - In Vivo Study By Contipro


Elasticity : 106% Elasticity Improvement Compared To The Placebo

Contipro Clodessine - In Vivo Study By Contipro - 1


Texture Improvement : 16% Pores Reduction

Contipro Clodessine - In Vivo Study By Contipro - 2

Mechanism of Action

Contipro Clodessine - Mechanism of Action

Klotho signaling pathways

  • Inhibits:
    • Insulin receptor
    • Insulin growth factor receptor
  • Similar to calorie restriction
  • Increases SOD2/catalase (enzymes neutralizing ROS)
  • Increases energy production.

Storage & Handling

Shelf Life
12 months