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SYN® UP

Sold by DSM
INCI Name: Sodium Hydroxide, Benzylsulfonyl D-Seryl Homophenylalanine Amidinobenzamide Acetate, Citric Acid
Function: Restoring Agent, Moisturizing Agent, Soothing Agent, Skin Barrier Protectant, Anti-Pollution Agent, Anti-Inflammatory
Ingredient Origin: Synthetic
Labeling Claims: BSE-free, Non-GMO, TSE-free, Preservative-free
Certifications & Compliance: EU Cosmetic Regulation 1223/2009 Compliant, REACH (Europe)
Benefit Claims: Rejuvenating, Anti-Aging, Skin Microbiome, Anti-Inflammatory, Conditioning, Non-Drying, Easy To Handle, Soothing, Restoring, Skin Protection, Promotes Youthful Skin, Skin Microbiome Friendly, Toning, Redness Reduction, Improves Skin Appearance, Moisturizing, Anti-Itching, Anti-Pollution, Improves Skin Resiliency, Elegant Feel, Barrier Function Improvement
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TypeDocument Name
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DSM Personal Care Brochure
DSM Personal Care Brochure
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Other
Peptides (SYN®-Peptides) Brochure
Peptides (SYN®-Peptides) Brochure
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Safety Data Sheet
SYN® UP Safety Data Sheet
SYN® UP Safety Data Sheet
Safety Data Sheet
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SYN-UP® Dry Skin Poster Infographic
SYN-UP® Dry Skin Poster Infographic
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Other
SYN-UP® Dry Skin Scientific Infographic
SYN-UP® Dry Skin Scientific Infographic
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Other
Research Paper - Moisturizing at a Molecular Level – The Basis of Corneocare
Research Paper - Moisturizing at a Molecular Level – The Basis of Corneocare
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Other
A Fresh Look at Bacteria SPC Trend Sheet
A Fresh Look at Bacteria SPC Trend Sheet
Other

Knowde Enhanced TDS

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Identification & Functionality

SYN® UP Features & Benefits

Product Highlights
  • Sophisticated patented synthetic dipeptide derivative 
  • Significant inhibition of urokinase activity by up to 97%
  • Significant inhibition of plasmin activity by up to 41% 
  • Significant reduction of MMP9 by up to 60%
  • Strong reduction of CXCL5 and IL-8 - markers for skin sensitivity and inflammation 
  • Inhibits Staphylococcus Aureus levels in vitro
  • Fights against dry skin conditions by boosting Staphylococcus 
  • Epidermidis levels - the influential keystone for healthy skin
  • Improves skin barrier and reduces high Corynebacterium Kroppenstedtii levels – a novel target for the control of skin redness 
Key Attributes
  • Fights against dry and red skin conditions
  • Makes skin more resilient to stress attacks day- by-day
  • Real, significant prevention of dry skin conditions
  • Visible, improvement of dry skin conditions
  • Impressive reduction of stinging sensations
  • Significant promotion of great looking skin

Applications & Uses

Mode Of Action

It has been shown in vitro that SYN® UP inhibits urokinase and plasmin and thus blocks downstream pathways, leading to high skin resilience and an improvement in dry skin conditions. DSM's novel, in vivo study reveals that SYN® UP fights against dry skin conditions and skin redness by boosting levels of Staphylococcus Epidermidis and reducing Corynebacterium Kroppenstedtii levels.

Application Mechanism

Restoring the Skin’s Youthful Resilience to Dry Skin Conditions

In skin conditions with reduced resilience such as dry skin, plasminogen is expressed in all epidermal cell layers and is activated by urokinase, causing release of plasmin. Plasmin and urokinase degrade and activate various proteins. This leads to degradation of corneodesmosomes, the intercellular adhesive structures that connect corneocytes, and to damage of extracellular structures, as well as to cells themselves, with increased desquamation of the skin. Plasmin activities also affect the cornified envelopes, which are important for the maintenance and integrity of the stratum corneum, and plasmin activates MMP 9, leading to increased levels of inflammatory cytokines. By influencing Staphylococcus Epidermidis and Corynebacterium Kroppenstedtii levels in the skin microbiome and rebalancing urokinase and plasmin symbiotically, SYN®-UP fights against dry skin conditions and redness. This means consumers can have confidence in achieving a stronger skin barrier and healthy-looking skin.

Properties

Physical Form
Appearance
Clear colorless to yellow viscous liquid
Soluble in
Water

Regulatory & Compliance

Storage & Handling

Shelf Life
24 months
SYN® UP
DSM