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SYN® AKE
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Identification & Functionality
Features & Benefits
Applications & Uses
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Technical Details & Test Data
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SYN® AKE

Stop wrinkling - Keep laughing. SYN® AKE is a small, patented, synthetic peptide that helps reduce the appearance of wrinkles and laughter lines - fast. As our skin gets older, the number of expression and laughter lines increases, along with crow's feet and forehead wrinkles. SYN® AKE enables the face to relax. It visibly reduces the appearance of wrinkles and expression lines. Thanks to its unique mode of action, SYN® AKE is fast acting and long lasting, with a fully reversible effect. SYN® AKE is a clear, colorless to yellowish, viscous liquid. For detailed regulatory or quality information, please contact the supplier.
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Identification & Functionality

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Chemical Family
Proteins, Peptides & Amino Acid Derivatives
INCI Name
Aqua Dipeptide Diaminobutyroyl Benzylamide Diacetate Glycerin
Cosmetic Ingredients Functions
Anti-Wrinkle Agent
Technologies
Cosmetic Ingredients
Product Families
Cosmetic Ingredients — Cosmetic Actives Skin Actives

Features & Benefits

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Benefit Claims
Anti-Aging Botox-Like Conditioning Long Lasting Moisturizing Myorelaxant Rejuvenating Relaxing
Labeling Claims
Alcohol-free BSE-free Cold Processable Non-GMO Porcine-free Preservative-free TSE-free
Origin
Synthetic
Product Highlights
  • Mimics Waglerin-1 functionality, a peptide found in the venom of the temple viper
  • Natural inspired mechanism
  • Preservative-free, glycerine-based aqueous solution
  • Safe for topical applications
  • Synthetic tripeptide with mol weight below 500 Da
  • Vegan-friendly
Key Attributes
  • Age-killing effect particularly effective against expression lines
  • Visible deep wrinkle smoothing after only 4 weeks
  • Helps your face to relax without losing the ability to express yourself
  • When used earlier in time, SYN®ï-AKE helps delaying the appearance of wrinkles, with age-freezing effect

Applications & Uses

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Markets
Home & Personal Care
Applications
Home & Personal Care — Beauty & Care Color Cosmetics Other Beauty & Care Skin Care Sun Care
Application Format
Creams Gel Lotions Masks Serum Spray
Skin Care Applications
Anti-Aging Products Around Eye Creams & Gels Face Creams & Lotions Masks & Facial Treatment
Sun Care Applications
Sunscreen Lotions Sunscreen Sprays
Treatment Products
Masks & Facial Treatment
Use Level
1 to 4%
Mode Of Action
  • SYN®-AKE is based on a patented mechanism. It mimics the essential amino acid sequence of the Waglerin-1 functionality.
  • Its effect focuses on an immediate and lasting relaxation of mimic wrinkles. In vitro the peptide cosmetic ingredient is considered as an antagonist at the muscular nicotinic acetylcholine receptor (mnAChR). As the muscular nicotinic ACh receptors are reversibly blocked, the ion channel remains closed. There is no uptake of Na+ and the muscle cells stay relaxed. The transmission of nerve impulses to the muscles is inhibited and facial muscles are relaxed.

Properties

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Ingredient Origin
Chemical Synthesis
Physical Form
Liquid
Physical Form
Liquid
Color
Yellow
Appearance
Clear yellow liquid
Miscible In
Water

Regulatory & Compliance

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Certifications & Compliance
EU Cosmetic Regulation 1223/2009 Compliant Halal IECIC (China) REACH (Europe)
Chemical Inventories
IECSC (China) TSCA Exempt (USA)

Storage & Handling

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Shelf Life
48 months

Most Viewed Documents

View All 6 Documents

Document Name
Type
Products
Learn More
DSM Personal Care Brochure
Other
PENTACARE-HP PF, ALPAFLOR® SAMBUCUS AO, ALPAFLOR® SCUTELLARIA AO, PREREGEN® PF, STAY-C® 50, TILAMAR® OP 40, TILAMAR® Fix A1000, TILAMAR® Quat 2240, TILAMAR® Quat 640, TILAMAR® Boost 150, VALVANCE® Touch 210, SYN® GLOW, SYN® STAR, SYN® TACKS, DSM Ascorbic Acid Fine Granular, COLHIBIN PF, STIMU-TEX® AS, ALL-Q (Coenzyme Q10) plus, PEPHA®-TIGHT, PENTAVITIN®, PEPHA®-CTIVE, ALPAFLOR® ARTEMISIA AO, ALPAFLOR® BUDDLEJA AO, DSM DL-α-Tocopheryl Acetate, PEPHA®-AGE, ALPAFLOR® NECTAPURE PF, ALPAFLOR® IMPERATORIA AO, DSM D-Biotin, ALPAFLOR® ALP-SEBUM CB, ALPAFLOR® EDELWEISS B, ALPAFLOR® EDELWEISS EP, ALPAFLOR® GIGAWHITE, ALPAFLOR® LINUM AO, BeauPlex® VH, ALPAFLOR® MARRUBIUM AO, DSM ALPHA-ARBUTIN, DISMUTIN® PF, DSM ARGAN OIL, DSM Ethyl Panthenol, DSM DL-α-Tocopherol, DSM D-Panthenol, DSM ERYTHRULOSE, DSM Folic acid, DSM HYALURONIC ACID-BT, HYDROLASTAN PF, HYASOL PF, DSM Mixed Tocopherols 95, IRICALMIN PF, DSM PHYTANTRIOL, DSM Niacinamide PC, LACTOMIDE, DSM Pyridoxine Hydrochloride, DSM RETINOL GS 50, DSM SERICIN, DSM Vitamin A Palmitate 1.7 MIU/g, ELHIBIN® PF, PEPHA®-PROTECT, MELAWHITE® PF, MELFADE® PF, PARSOL® 5000, PARSOL® Guard, PARSOL® HMS, PARSOL® HS, PARSOL® SLX, PENTAGLYCAN PF, PHYTALURONATE® PF, REGU®-FADE, REGU®-SEB, REGU®-SCENCE, REVITALIN® PF, REGU®-SLIM, REGU®-STRETCH, SETAKOL® PF, SYN® AKE, SYN® EYE, SYN® TC, SYN® HYCAN, PARSOL® Max, SYN® UP, REGU®-AGE PF, DSM Ascorbic Acid Fine Powder, BEAUACTIVE®, Life’s GLA™ ‘10’ n-6 Oil, BEL-EVEN®, DSM D-Panthenol 75L, OXY 229 PF, PENTACARE-NA PF, Life’s GLA™ '25' n-6 Oil, DSM DL-Panthenol 50 L, CEPHALIPIN NP 2, DSM Ascorbic Acid Ultra Fine Powder, DSM D-α-Tocopheryl Acetate, DSM Vitamin A Palmitate 1.0 MIU/g (tocopherol), DSM Vitamin A Palmitate 1.0 MIU/g (BHA/BHT), DSM Vitamin A Palmitate 1.7 MIU/g (tocopherol), DSM Vitamin A Palmitate 1.7 MIU/g (BHA/BHT), DSM Vitamin A Palmitate/M 1.0 MIU/g (tocopherol), PARSOL® 1789, PARSOL® 340, PARSOL® EHS, PARSOL® Shield, PARSOL® MCX, PARSOL® TX, PARSOL® ZX, DSM ALLANTOIN, SYN® COLL, ALPAFLOR® MALVA AO, AMPHISOL® A, AMPHISOL® K, LIPOGARD, DSM COLLAGEN 1%, DSM COLLAGEN BOVINE 1%, VALVANCE® Look 100, VALVANCE® Touch 250, DSM Vitamin A Acetate 1.5 MIU/g
View
View Document
Other
Products: PENTACARE-HP PF, ALPAFLOR® SAMBUCUS AO, ALPAFLOR® SCUTELLARIA AO, PREREGEN® PF, STAY-C® 50, TILAMAR® OP 40, TILAMAR® Fix A1000, TILAMAR® Quat 2240, TILAMAR® Quat 640, TILAMAR® Boost 150, VALVANCE® Touch 210, SYN® GLOW, SYN® STAR, SYN® TACKS, DSM Ascorbic Acid Fine Granular, COLHIBIN PF, STIMU-TEX® AS, ALL-Q (Coenzyme Q10) plus, PEPHA®-TIGHT, PENTAVITIN®, PEPHA®-CTIVE, ALPAFLOR® ARTEMISIA AO, ALPAFLOR® BUDDLEJA AO, DSM DL-α-Tocopheryl Acetate, PEPHA®-AGE, ALPAFLOR® NECTAPURE PF, ALPAFLOR® IMPERATORIA AO, DSM D-Biotin, ALPAFLOR® ALP-SEBUM CB, ALPAFLOR® EDELWEISS B, ALPAFLOR® EDELWEISS EP, ALPAFLOR® GIGAWHITE, ALPAFLOR® LINUM AO, BeauPlex® VH, ALPAFLOR® MARRUBIUM AO, DSM ALPHA-ARBUTIN, DISMUTIN® PF, DSM ARGAN OIL, DSM Ethyl Panthenol, DSM DL-α-Tocopherol, DSM D-Panthenol, DSM ERYTHRULOSE, DSM Folic acid, DSM HYALURONIC ACID-BT, HYDROLASTAN PF, HYASOL PF, DSM Mixed Tocopherols 95, IRICALMIN PF, DSM PHYTANTRIOL, DSM Niacinamide PC, LACTOMIDE, DSM Pyridoxine Hydrochloride, DSM RETINOL GS 50, DSM SERICIN, DSM Vitamin A Palmitate 1.7 MIU/g, ELHIBIN® PF, PEPHA®-PROTECT, MELAWHITE® PF, MELFADE® PF, PARSOL® 5000, PARSOL® Guard, PARSOL® HMS, PARSOL® HS, PARSOL® SLX, PENTAGLYCAN PF, PHYTALURONATE® PF, REGU®-FADE, REGU®-SEB, REGU®-SCENCE, REVITALIN® PF, REGU®-SLIM, REGU®-STRETCH, SETAKOL® PF, SYN® AKE, SYN® EYE, SYN® TC, SYN® HYCAN, PARSOL® Max, SYN® UP, REGU®-AGE PF, DSM Ascorbic Acid Fine Powder, BEAUACTIVE®, Life’s GLA™ ‘10’ n-6 Oil, BEL-EVEN®, DSM D-Panthenol 75L, OXY 229 PF, PENTACARE-NA PF, Life’s GLA™ '25' n-6 Oil, DSM DL-Panthenol 50 L, CEPHALIPIN NP 2, DSM Ascorbic Acid Ultra Fine Powder, DSM D-α-Tocopheryl Acetate, DSM Vitamin A Palmitate 1.0 MIU/g (tocopherol), DSM Vitamin A Palmitate 1.0 MIU/g (BHA/BHT), DSM Vitamin A Palmitate 1.7 MIU/g (tocopherol), DSM Vitamin A Palmitate 1.7 MIU/g (BHA/BHT), DSM Vitamin A Palmitate/M 1.0 MIU/g (tocopherol), PARSOL® 1789, PARSOL® 340, PARSOL® EHS, PARSOL® Shield, PARSOL® MCX, PARSOL® TX, PARSOL® ZX, DSM ALLANTOIN, SYN® COLL, ALPAFLOR® MALVA AO, AMPHISOL® A, AMPHISOL® K, LIPOGARD, DSM COLLAGEN 1%, DSM COLLAGEN BOVINE 1%, VALVANCE® Look 100, VALVANCE® Touch 250, DSM Vitamin A Acetate 1.5 MIU/g
Trends Vitamins for Healthy and Beauty Skins Vitamin B3
Other
STIMU-TEX® AS, PENTAVITIN®, DSM DL-α-Tocopheryl Acetate, PEPHA®-AGE, DSM HYALURONIC ACID-BT, DSM Niacinamide PC, PARSOL® HS, PARSOL® SLX, SYN® AKE, PARSOL® 1789, PARSOL® 340, PARSOL® EHS, PARSOL® Shield, AMPHISOL® K, TILAMAR® PDO with NØØVISTA™
View
View Document
Other
Products: STIMU-TEX® AS, PENTAVITIN®, DSM DL-α-Tocopheryl Acetate, PEPHA®-AGE, DSM HYALURONIC ACID-BT, DSM Niacinamide PC, PARSOL® HS, PARSOL® SLX, SYN® AKE, PARSOL® 1789, PARSOL® 340, PARSOL® EHS, PARSOL® Shield, AMPHISOL® K, TILAMAR® PDO with NØØVISTA™
Trends Vitamins for Healthy and Beauty Skins Vitamin E
Other
STIMU-TEX® AS, PENTAVITIN®, DSM DL-α-Tocopheryl Acetate, ALPAFLOR® EDELWEISS B, DSM Mixed Tocopherols 95, DSM Niacinamide PC, PARSOL® HS, PARSOL® SLX, SYN® AKE, Life’s GLA™ ‘10’ n-6 Oil, PARSOL® 1789, PARSOL® 340, SYN® COLL, AMPHISOL® K, LIPOGARD
View
View Document
Other
Products: STIMU-TEX® AS, PENTAVITIN®, DSM DL-α-Tocopheryl Acetate, ALPAFLOR® EDELWEISS B, DSM Mixed Tocopherols 95, DSM Niacinamide PC, PARSOL® HS, PARSOL® SLX, SYN® AKE, Life’s GLA™ ‘10’ n-6 Oil, PARSOL® 1789, PARSOL® 340, SYN® COLL, AMPHISOL® K, LIPOGARD
Peptides (SYN®-Peptides) Brochure
Other
SYN® STAR, SYN® TACKS, SYN® AKE, SYN® EYE, SYN® TC, SYN® HYCAN, SYN® UP, SYN® COLL
View
View Document
Other
Products: SYN® STAR, SYN® TACKS, SYN® AKE, SYN® EYE, SYN® TC, SYN® HYCAN, SYN® UP, SYN® COLL
SYN® AKE Safety Data Sheet
Safety Data Sheet
SYN® AKE
View
View Document
Safety Data Sheet
Products: SYN® AKE
DSM Sustainability Imp’Act Card™
Other
ALPAFLOR® SCUTELLARIA AO, TILAMAR® Boost 150, VALVANCE® Touch 210, SYN® GLOW, PENTAVITIN®, ALPAFLOR® NECTAPURE PF, ALPAFLOR® ALP-SEBUM CB, ALPAFLOR® EDELWEISS B, ALPAFLOR® EDELWEISS EP, ALPAFLOR® GIGAWHITE, DSM DL-α-Tocopherol, DSM D-Panthenol, DSM Mixed Tocopherols 95, DSM Niacinamide PC, SYN® AKE, PARSOL® 1789, PARSOL® Shield, PARSOL® MCX, PARSOL® TX, PARSOL® ZX, AMPHISOL® K
View
View Document
Other
Products: ALPAFLOR® SCUTELLARIA AO, TILAMAR® Boost 150, VALVANCE® Touch 210, SYN® GLOW, PENTAVITIN®, ALPAFLOR® NECTAPURE PF, ALPAFLOR® ALP-SEBUM CB, ALPAFLOR® EDELWEISS B, ALPAFLOR® EDELWEISS EP, ALPAFLOR® GIGAWHITE, DSM DL-α-Tocopherol, DSM D-Panthenol, DSM Mixed Tocopherols 95, DSM Niacinamide PC, SYN® AKE, PARSOL® 1789, PARSOL® Shield, PARSOL® MCX, PARSOL® TX, PARSOL® ZX, AMPHISOL® K

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