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Kalrez® 6221
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Kalrez® 6221

Kalrez® 6221 perfluoroelastomer parts are a white product that provide superior chemical resistance and low contamination from extractables in pharmaceutical and food handling applications where FDA compliance is required. Kalrez® 6221 parts are especially suited for Water for Injection (WFI) systems, Steam-in-Place (SIP) cleaning and other critical systems. Kalrez° 6221 parts are thermally stable up to 260°C (500°F), permitting them to be used in Stage II Sterilization processes, where other elastomers lose their sealing ability. Kalrez® 6221 is available as O-rings. For white custom parts, please refer to Kalrez® LS205 parts.
Product Resources

Knowde Enhanced TDS

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Identification & Functionality

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Features & Benefits

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Applications & Uses

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Properties

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Typical Properties
ValueUnitsTest Method / Conditions
Maximum Application Temperature260 (500)°C (°F)-
Durometer70Shore AASTM D2240
Compression Set (70 hr, 200°C, 392°F)27%ASTM D395B
Elongation at Break150%ASTM D412
Tensile Strength at Break15.16 (2199)MPa (psi)ASTM D1414
ColorWhite--
100% Modulus7.24 (1049)MPa (psi)ASTM D1414
Color
White
Chemical Resistance

The overall chemical resistance of EPDMs, silicone elastomers and fluoroelastomers (FKM) is limited by their respective polymer structures. Kalrez® parts, on the other hand, offer the same universal chemical resistance as PTFE, but unlike PTFE, they have elastomeric properties, which help them maintain their sealing capa bilities. The following table lists the chemical compatibility of Kalrez® 6221 perfluoroelastomer parts and other elastomers used as sealing materials in the pharmaceutical and food handling industries

Chemical Resistance

Kalrez® 6221

EPDM Si FKM
Acetic Acid A A A B
Acetone A A C U
Citric Acid A A A A
Hydrogen Peroxide A B B B
Isopropyl Alcohol A A A A
Methyl Ethyl Ketone A A U U
Mineral Oil A U B A
NaOH A A B B
Nitric Acid A B B A
Sodium Hypochlorite A B B A
Soybean Oil A C A A
Steam (<150°C) A A C C
Steam (>150°C) A C U U
Toluene A U U A
Xylene A U U A
Maximum Service Temperature

260°C (500°F)

135°C (275°F)

200°C (392°F)

200°C (392°F)

A = little or no effect

B = slight swelling and/or loss of physical properties

C = moderate to severe swelling and/or loss of physical properties/limited functionality

U = not suitable or recommended

Technical Details & Test Data

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Water Resistance

In aggressive pharmaceutical processing environments, seal failure from excess swelling, embrittlement, or decomposition can cause unscheduled downtime or product contamination. Elastomeric materials that come in contact with highly pure and aggressive water (e.g. WFI) must be chosen with care in order to prolong seal life. The perfluoroelastomer compounds used in Kalrez® parts have been shown to have extremely low, to non-detectable extractable levels in aggressive water systems. Because the perfluoroelastomer polymer in Kalrez® parts is fully saturated, it is also well suited for Ozonated Deionized Water service. Kalrez® parts also exhibit very low swell and loss of mechanical properties after repeated steam cycling.

Documents (28)

Document Name
Type
Products
Technical Data Sheet
Kalrez® 6221
Technical Data Sheet
Products: Kalrez® 6221
Brochure
Kalrez® 1050LF, Kalrez® 3018, Kalrez® 3035, Kalrez® 3065, Kalrez® 4079, Kalrez® 6190, Kalrez® 6221, Kalrez® 6375UP, Kalrez® 7075UP, Kalrez® 8002, Kalrez® 8085, Kalrez® 9100, Kalrez® 9300, Kalrez® 9600, Kalrez® AeroSeal™ 7777, Kalrez® AS-568, Kalrez® Bonded Door Seals, Kalrez® LS390, Kalrez® Metric O-rings, Kalrez® MS220, Kalrez® Seals, Kalrez® Spectrum™ 0040, Kalrez® Spectrum™ 6375, Kalrez® Spectrum™ 6380, Kalrez® Spectrum™ 7090, Kalrez® Spectrum™ 7275, Kalrez® TriLobe™ Seals, Kalrez® 0090, Kalrez® Spectrum™ 4001, Kalrez® 4079AMS, Kalrez® 6230, Kalrez® 8705, Kalrez® 8900, Kalrez® 9500, Kalrez® AeroSeal™ 7800, Kalrez® CP222, Kalrez® LS205, Kalrez® Spectrum™ 7375, Kalrez® KVSP™, Kalrez® V-Rings, Kalrez® PV8070, Kalrez® 8475, Kalrez® 8575, Kalrez® Spectrum™ 7075, Kalrez® W240, Kalrez® AeroSeal® 7797
Brochure
Products: Kalrez® 1050LF, Kalrez® 3018, Kalrez® 3035, Kalrez® 3065, Kalrez® 4079, Kalrez® 6190, Kalrez® 6221, Kalrez® 6375UP, Kalrez® 7075UP, Kalrez® 8002, Kalrez® 8085, Kalrez® 9100, Kalrez® 9300, Kalrez® 9600, Kalrez® AeroSeal™ 7777, Kalrez® AS-568, Kalrez® Bonded Door Seals, Kalrez® LS390, Kalrez® Metric O-rings, Kalrez® MS220, Kalrez® Seals, Kalrez® Spectrum™ 0040, Kalrez® Spectrum™ 6375, Kalrez® Spectrum™ 6380, Kalrez® Spectrum™ 7090, Kalrez® Spectrum™ 7275, Kalrez® TriLobe™ Seals, Kalrez® 0090, Kalrez® Spectrum™ 4001, Kalrez® 4079AMS, Kalrez® 6230, Kalrez® 8705, Kalrez® 8900, Kalrez® 9500, Kalrez® AeroSeal™ 7800, Kalrez® CP222, Kalrez® LS205, Kalrez® Spectrum™ 7375, Kalrez® KVSP™, Kalrez® V-Rings, Kalrez® PV8070, Kalrez® 8475, Kalrez® 8575, Kalrez® Spectrum™ 7075, Kalrez® W240, Kalrez® AeroSeal® 7797
Brochure
Kalrez® 1050LF, Kalrez® 3018, Kalrez® 3035, Kalrez® 3065, Kalrez® 4079, Kalrez® 6190, Kalrez® 6221, Kalrez® 6375UP, Kalrez® 7075UP, Kalrez® 8002, Kalrez® 8085, Kalrez® 9100, Kalrez® 9300, Kalrez® 9600, Kalrez® AeroSeal™ 7777, Kalrez® AS-568, Kalrez® Bonded Door Seals, Kalrez® LS390, Kalrez® Metric O-rings, Kalrez® MS220, Kalrez® Seals, Kalrez® Spectrum™ 0040, Kalrez® Spectrum™ 6375, Kalrez® Spectrum™ 6380, Kalrez® Spectrum™ 7090, Kalrez® Spectrum™ 7275, Kalrez® TriLobe™ Seals, Kalrez® 0090, Kalrez® Spectrum™ 4001, Kalrez® 4079AMS, Kalrez® 6230, Kalrez® 8705, Kalrez® 8900, Kalrez® 9500, Kalrez® AeroSeal™ 7800, Kalrez® CP222, Kalrez® LS205, Kalrez® Spectrum™ 7375, Kalrez® KVSP™, Kalrez® V-Rings, Kalrez® PV8070, Kalrez® 8475, Kalrez® 8575, Kalrez® Spectrum™ 7075, Kalrez® W240, Kalrez® AeroSeal® 7797
Brochure
Products: Kalrez® 1050LF, Kalrez® 3018, Kalrez® 3035, Kalrez® 3065, Kalrez® 4079, Kalrez® 6190, Kalrez® 6221, Kalrez® 6375UP, Kalrez® 7075UP, Kalrez® 8002, Kalrez® 8085, Kalrez® 9100, Kalrez® 9300, Kalrez® 9600, Kalrez® AeroSeal™ 7777, Kalrez® AS-568, Kalrez® Bonded Door Seals, Kalrez® LS390, Kalrez® Metric O-rings, Kalrez® MS220, Kalrez® Seals, Kalrez® Spectrum™ 0040, Kalrez® Spectrum™ 6375, Kalrez® Spectrum™ 6380, Kalrez® Spectrum™ 7090, Kalrez® Spectrum™ 7275, Kalrez® TriLobe™ Seals, Kalrez® 0090, Kalrez® Spectrum™ 4001, Kalrez® 4079AMS, Kalrez® 6230, Kalrez® 8705, Kalrez® 8900, Kalrez® 9500, Kalrez® AeroSeal™ 7800, Kalrez® CP222, Kalrez® LS205, Kalrez® Spectrum™ 7375, Kalrez® KVSP™, Kalrez® V-Rings, Kalrez® PV8070, Kalrez® 8475, Kalrez® 8575, Kalrez® Spectrum™ 7075, Kalrez® W240, Kalrez® AeroSeal® 7797
Brochure
Kalrez® 1050LF, Kalrez® 3018, Kalrez® 3035, Kalrez® 3065, Kalrez® 4079, Kalrez® 6190, Kalrez® 6221, Kalrez® 6375UP, Kalrez® 7075UP, Kalrez® 8002, Kalrez® 8085, Kalrez® 9100, Kalrez® 9300, Kalrez® 9600, Kalrez® AeroSeal™ 7777, Kalrez® AS-568, Kalrez® Bonded Door Seals, Kalrez® LS390, Kalrez® Metric O-rings, Kalrez® MS220, Kalrez® Seals, Kalrez® Spectrum™ 0040, Kalrez® Spectrum™ 6375, Kalrez® Spectrum™ 6380, Kalrez® Spectrum™ 7090, Kalrez® Spectrum™ 7275, Kalrez® TriLobe™ Seals, Kalrez® 0090, Kalrez® Spectrum™ 4001, Kalrez® 4079AMS, Kalrez® 6230, Kalrez® 8705, Kalrez® 8900, Kalrez® 9500, Kalrez® AeroSeal™ 7800, Kalrez® CP222, Kalrez® LS205, Kalrez® Spectrum™ 7375, Kalrez® KVSP™, Kalrez® V-Rings, Kalrez® PV8070, Kalrez® 8475, Kalrez® 8575, Kalrez® Spectrum™ 7075, Kalrez® W240, Kalrez® AeroSeal® 7797
Brochure
Products: Kalrez® 1050LF, Kalrez® 3018, Kalrez® 3035, Kalrez® 3065, Kalrez® 4079, Kalrez® 6190, Kalrez® 6221, Kalrez® 6375UP, Kalrez® 7075UP, Kalrez® 8002, Kalrez® 8085, Kalrez® 9100, Kalrez® 9300, Kalrez® 9600, Kalrez® AeroSeal™ 7777, Kalrez® AS-568, Kalrez® Bonded Door Seals, Kalrez® LS390, Kalrez® Metric O-rings, Kalrez® MS220, Kalrez® Seals, Kalrez® Spectrum™ 0040, Kalrez® Spectrum™ 6375, Kalrez® Spectrum™ 6380, Kalrez® Spectrum™ 7090, Kalrez® Spectrum™ 7275, Kalrez® TriLobe™ Seals, Kalrez® 0090, Kalrez® Spectrum™ 4001, Kalrez® 4079AMS, Kalrez® 6230, Kalrez® 8705, Kalrez® 8900, Kalrez® 9500, Kalrez® AeroSeal™ 7800, Kalrez® CP222, Kalrez® LS205, Kalrez® Spectrum™ 7375, Kalrez® KVSP™, Kalrez® V-Rings, Kalrez® PV8070, Kalrez® 8475, Kalrez® 8575, Kalrez® Spectrum™ 7075, Kalrez® W240, Kalrez® AeroSeal® 7797
Brochure
Kalrez® 1050LF, Kalrez® 3018, Kalrez® 3035, Kalrez® 3065, Kalrez® 4079, Kalrez® 6190, Kalrez® 6221, Kalrez® 6375UP, Kalrez® 7075UP, Kalrez® 8002, Kalrez® 8085, Kalrez® 9100, Kalrez® 9300, Kalrez® 9600, Kalrez® AeroSeal™ 7777, Kalrez® AS-568, Kalrez® Bonded Door Seals, Kalrez® LS390, Kalrez® Metric O-rings, Kalrez® MS220, Kalrez® Seals, Kalrez® Spectrum™ 0040, Kalrez® Spectrum™ 6375, Kalrez® Spectrum™ 6380, Kalrez® Spectrum™ 7090, Kalrez® Spectrum™ 7275, Kalrez® TriLobe™ Seals, Kalrez® 0090, Kalrez® Spectrum™ 4001, Kalrez® 4079AMS, Kalrez® 6230, Kalrez® 8705, Kalrez® 8900, Kalrez® 9500, Kalrez® AeroSeal™ 7800, Kalrez® CP222, Kalrez® LS205, Kalrez® Spectrum™ 7375, Kalrez® KVSP™, Kalrez® V-Rings, Kalrez® PV8070, Kalrez® 8475, Kalrez® 8575, Kalrez® Spectrum™ 7075, Kalrez® W240, Kalrez® AeroSeal® 7797
Brochure
Products: Kalrez® 1050LF, Kalrez® 3018, Kalrez® 3035, Kalrez® 3065, Kalrez® 4079, Kalrez® 6190, Kalrez® 6221, Kalrez® 6375UP, Kalrez® 7075UP, Kalrez® 8002, Kalrez® 8085, Kalrez® 9100, Kalrez® 9300, Kalrez® 9600, Kalrez® AeroSeal™ 7777, Kalrez® AS-568, Kalrez® Bonded Door Seals, Kalrez® LS390, Kalrez® Metric O-rings, Kalrez® MS220, Kalrez® Seals, Kalrez® Spectrum™ 0040, Kalrez® Spectrum™ 6375, Kalrez® Spectrum™ 6380, Kalrez® Spectrum™ 7090, Kalrez® Spectrum™ 7275, Kalrez® TriLobe™ Seals, Kalrez® 0090, Kalrez® Spectrum™ 4001, Kalrez® 4079AMS, Kalrez® 6230, Kalrez® 8705, Kalrez® 8900, Kalrez® 9500, Kalrez® AeroSeal™ 7800, Kalrez® CP222, Kalrez® LS205, Kalrez® Spectrum™ 7375, Kalrez® KVSP™, Kalrez® V-Rings, Kalrez® PV8070, Kalrez® 8475, Kalrez® 8575, Kalrez® Spectrum™ 7075, Kalrez® W240, Kalrez® AeroSeal® 7797