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Eastman C-A-P Cellulose Ester NF Powder
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Producer: 
Eastman
Eastman™ C-A-P (Cellulose Acetate Phthalate, NF) enteric coating material is a pH-sensitive cellulose derivative designed for coating pharmaceutical tablets, capsules or granules. It may also be used as a matrix material in solid dose forms. C-A-P enteric coating material withstands prolonged contact with acidic gastric fluids, but it dissolves readily in the mildly acidic to neutral environment of the small intestine. It can be applied to tablets, capsules or granules from solutions of organic solvents. C-A-P meets USP and NF specifications and is available in powder and pellet form.

Eastman C-A-P Cellulose Ester NF Powder

Producer: 
Eastman
Eastman™ C-A-P (Cellulose Acetate Phthalate, NF) enteric coating material is a pH-sensitive cellulose derivative designed for coating pharmaceutical tablets, capsules or granules. It may also be used as a matrix material in solid dose forms. C-A-P enteric coating material withstands prolonged contact with acidic gastric fluids, but it dissolves readily in the mildly acidic to neutral environment of the small intestine. It can be applied to tablets, capsules or granules from solutions of organic solvents. C-A-P meets USP and NF specifications and is available in powder and pellet form.
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Features & Benefits

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Product Highlights
  • pH-sensitive as it hydrolyzes at pH 6 or higher
  • Solvent based
  • Stable if stored in a sealed container in a cool, dry place
  • Two physical forms: powder and pellet
  • Compressible
  • Multiple plasticizers are appropriate for use with C-A-P.
  • Advantage over water-based coatings materials:coats very small tablets or water-sensitive actives
  • Best if used in solvent systems
  • Adding a plasticizer increases film flexibility.
  • Can be used in aqueous systems through ammonia
    neutralization
  • Can be used at levels as low as 0.5%

Applications & Uses

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Recommended Uses
  • Enteric coating for tablets, softgels, and granules
  • Binder to make tablets for delayed release via direct compression

Properties

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Typical Properties
ValueUnitsTest Method / Conditions
Viscositya at 25°C45-90cP-
Composition Moisturemax. 5.0wt %-
Composition Free Acid as Phthalic Acidmax. 3.0wt %-
Composition Phthalyl30-36%-
Composition Acetyl21.5-26%-
Physical Form
White powder

Storage & Handling

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Storage and Handling
  • Eastman C-A-P enteric coating material is packaged and sealed in moisture-resistant fiber drums equipped with polyethylene inner liners and reusable metal closures.
  • Drums held in cool, dry storage should be brought to room temperature before opening to prevent condensation on inside surfaces.
  • Under prolonged storage at high temperatures or high humidity, C-A-P will slowly hydrolyze, increasing the free acid content.
  • Eastman cellulose esters are packed and sealed in fiber drums equipped with a polyethylene inner liner and reusable metal closure.
  • These containers should be sealed and protected from moisture or high humidity for extended periods.
  • Drums held in cool, dry storage should be brought to room temperature before opening to prevent condensation of moisture on inside surfaces.

Documents (8)

Name
Type
Eastman Chemical Company's certification of kosher products
Brochure
Cellulose ester blends for tunable drug delivery
Brochure
Eastman pharmaceutical excipients
Other
Eastman C-A-P enteric coating material
Other
C-A-P cellulose ester NF (powder) Sales Specifications Sheet
Other