product
Producer:
Eastman Eastman™ Cellulose Acetate (CA-398-10NF/EP) is a low viscosity solution grade of cellulose acetate. It is the most commonly used coating material as the semi-permeable membrane for osmotic (controlled-release) drug delivery. It is also used for taste-masking and tableting. CA-398-10NF/EP is made under cGMP and meets the requirements of the National Formulary (NF) and European Pharmacopoeia (EP). CA-398-10NF/EP is available in powder form.
Eastman (CA-398-10NF/EP) Cellulose Acetate
Producer:
Eastman Eastman™ Cellulose Acetate (CA-398-10NF/EP) is a low viscosity solution grade of cellulose acetate. It is the most commonly used coating material as the semi-permeable membrane for osmotic (controlled-release) drug delivery. It is also used for taste-masking and tableting. CA-398-10NF/EP is made under cGMP and meets the requirements of the National Formulary (NF) and European Pharmacopoeia (EP). CA-398-10NF/EP is available in powder form.
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Features & Benefits
Product Highlights
- For use in coatings: semipermeable, excellent film former,strong, flexible
- Characteristics of coating can be modified (permeability,
mechanical strength, flexibility) through blending two CAs or CA with CAB. - For use in tableting directly compressible, matrix for sustained release
- CAB is more hydrophobic than CA.
- Requires a solvent for coatings formulations
- Modify a wide range of film properties through additives
- Adjust sustained release by blending CA with CAB
- Acetyl Content in CA-398-10 NF/EP polymer is in range of 39.3%-40.3%
- Permeability of coating film increases with decrease in acetyl content.
Applications & Uses
Recommended Uses
- Semipermeable membrane for osmotic drug delivery
systems - Coating for extended-release tablets
- Coating for taste masking
- Binder to make tablets for sustained release via direct
compression
Properties
Physical Properties
| Value | Units | Test Method / Conditions | |
| Odor | Odorless | ||
| Solubility in Water | Negligible |
Typical Properties
| Value | Units | Test Method / Conditions | |
| Color | White | - | - |
| Solubility in Water | Negligible | - | - |
| Acetyl Content | 39.3-40.3 | % | |
| Loss on Drying | max 5 | wt % | |
| Viscosity | 44056.0 | Pa.s | ASTM A |
| Acetyl Content | 39.3-40.3 | % | - |
| Loss on Drying | max. 5 | wt % | - |
| Viscosity | 44056.0 | - | ASTM A |
Physical Form
Solid (powder)
Appearance
White
Insoluble in
Water
Packaging & Availability
Regional Availability
Storage & Handling
Storage and Handling
- Eastman cellulose esters are packed and sealed in fiber drums equipped with a polyethylene inner liner and reusable metal closure.
- These containers should be sealed and protected from moisture or high humidity for extended periods.
- Drums held in cool, dry storage should be brought to room temperature before opening to prevent condensation of moisture on inside surfaces.
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