Knowde Enhanced TDS
Identification & Functionality
- Active Component
- Ingredient Name
- Pharma & Nutraceuticals Functions
- Ingredients
- Cranberry Extract
- Product Families
Features & Benefits
- Benefit Claims (Health)
- Labeling Claims
- Food Ingredients Features
- Product Highlights
- North Americans have used cranberries for centuries as a valuable and nutritious food source, but in recent years cranberry’s therapeutic use has focused primarily on the ability to support urinary tract health, particularly for those prone to recurrent UTI’s.
- The constituent in cranberry responsible for its therapeutic effect was for long a matter of speculation. Today scientific consensus is that cranberry’s activity is due to its unique proanthocyanidins (PAC’s) containing the ‘A-type’ linkages, not found in PAC’s from other sources. Cranberex® is standardized to a high level (15%) of these ‘A-type’ linkage PAC’s.
- Anti-Adhesion Activity (AAA) of cranberry : Cranberries support UTH in a unique way: the A-Type PACs inhibit the adhesion of E.coli bacteria to walls of the urinary tract. Studies have confi rmed that this eff ect is specifi c to the A-linked PAC’s (cranberry), but not to other PAC rich foods with the more common B-type linkages (e.g. chocolate and grapes) [1]. As this bacterial anti-adhesion mechanism does not kill bacteria, there is less chance of selection for resistant bacterial strains. This has been considered as an advantage compared to antibiotics treatment for UTI’s and in some cases more eff ective in reducing the re-occurrence of UTI’s.
Applications & Uses
- Applications
- Dosage Level
The recent, multicentric randomized, double blind clinical trial clearly affirmed, for the first time, a bacterial anti-adhesion effect in urine, based upon 36 mg/day of cranberry PAC (by BL-DMAC method). It also reported that effectiveness was dose-dependent, prolonged up to 24 hours with 72 mg of PAC, and increasing with the amount of PAC (by BL-DMAC method) consumed. Cranberex® is standardized to 15% PACs, and provides these dosages with consumption of 480mg (72mg PAC) and 240mg (36mg PAC) respectively.
Properties
- Appearance
- Dark red fine powder
- Odor
- Characteristic
- Microbiological Values
- Nutritional Information
- Assay
- Heavy Metals
- Nutritional Information Remarks
- There is no added sugar or added sodium in this product; there is no significant amount of dietary fiber in this product.
- This product is not a significant source of vitamins or minerals, including the following nutrients: Vitamin A, Niacin, Folate, Vitamin D, Vitamin E, and Potassium.
| Value | Units | Test Method / Conditions | |
| Total Plate Count | max. 10,000 | cfu/g | USP/AOAC |
| Yeast & Mold | max. 1,000 | cfu/g | USP/AOAC |
| Total Coliforms | Negative | — | USP/AOAC |
| Escherichia coli | Absent | /10g | USP/AOAC |
| Salmonella | Absent | /25 g | USP/AOAC |
| Value | Units | Test Method / Conditions | |
| Energy | 380 - 420 | Kcal/100g | AOAC |
| Total Fat | max. 8 | g/100g | Gravimetric |
| Total Protein | max. 3 | g/100g | TKN |
| Total Carbohydrates | 85 - 95 | g/100g | AOAC |
| Sodium | max. 0.2 | g/100g | AA |
| Dry Wt. | min. 95 | g/100g | Gravimetric |
| Total Ash | max. 0.5 | g/100g | Gravimetric |
| Value | Units | Test Method / Conditions | |
| Cranberry PACs | min. 15 | % | AOAC-DMAC |
| Value | Units | Test Method / Conditions | |
| Arsenic Content | max. 0.5 | ppm | USP |
| Cadmium Content | max. 1.0 | ppm | USP |
| Lead Content | max. 0.5 | ppm | USP |
| Mercury Content | max. 0.1 | ppm | USP |
Regulatory & Compliance
- Certifications & Compliance
- Regulatory Information
- Control points verified at ENI Internal Quality Control Lab and/or an FDA Registered lab in accordance with ENI product approval and testing protocol (ENI.SOP.H.1).
- Extracted by Distilled Water with extract ratio of approximate 200-250:1 (fresh fruit basis); non-GMO Ethanol is used at elution step; no excipient or carrier is used; Non-GMO; ETO-free and not irradiated; residual solvents comply with USP <467>.
Technical Details & Test Data
- Science Behind Cranberex®
Potency assay methods : The accurate measurement of total Cranberry A-Type PAC’s has presented a challenge, due to their structural complexity and degree of polymerization. A number of analytical methods, such as: colorimetric, chromatographic and MS have been used. However the results produced by these methods are variable, difficult to reproduce, and don’t distinguish clearly between PAC’s from Cranberry and other sources.
The BL-DMAC method : In 2010 however, the BL-DMAC method for quantifying the A-Type PAC’s in Cranberry was published. This method has now been endorsed by a number of international labs and authorities, including the USDA and Rutgers University. It was also used for validating cranberry UTI claims in the EU. This DMAC method now allows health claims to be made that correspond most accurately to specifi c amounts of Cranberry PAC's.
Fig.1 – mg of A-Type PAC’s per cap/tab of leading cranberry extracts
In-Vitro Anti-Adhesion Activity (AAA) data from Rutgers University : This in-vitro study compared the AAA of Cranberex® with nine other brands of cranberry extract (raw material and fi nished products). In this study, Cranberex® met the anti-adhesion criteria at a concentration of only 0.23mg/mL. The next most potent brand required a concentration of 60mg/mL to achieve the same anti- adhesion result. The study concluded that Cranberex® had excellent anti-adhesion activity.
Ex-Vivo AAA study from Rutgers University* : This study, was designed to test actual anti-adhesion activity in the urine after consumption of two doses (1 dose in the evening and 1 dose in the morning) of Cranberex® (at recommended dosage level) in human participants. The report states that AAA response increased rapidly in all participants 3 - 6 hours after consumption of Cranberex®. Half of the participants achieved 100% or signifi cant bacterial Anti-Adhesion Activity, while half achieved 50%, resulting in an average of 75% AAA. (See fig 2).
Fig. 2 – Avg. AA activity of 10 subjects after consuming 36mg A-Type PAC’s from cranberry, (Cranberex®, Ethical Naturals Inc.).
Storage & Handling
- Shelf Life
- 3 Years
- Storage
3 years in sealed container(s) under a controlled room or cool temperature; low humidity environment; away from light.