Knowde Enhanced TDS
Identification & Functionality
- Carrier
- Ingredient Origin
- Cosmetic Ingredients Functions
- CAS No.
- 8024-32-6
- Technologies
Features & Benefits
- Benefit Claims
- Labeling Claims
- Product Background
EFFIPULP®, a concentrate of peptides from an enzymatic hydrolysis of delipidated avocado pulp, is obtained through a green process that respects the fruit’s natural state
Proteasome activation: detoxifying effect & replumped skin
Over time, the skin’s defense and detoxification systems become less effective: free radicals accumulate, and cellular functions are impaired. This means that the synthesis of proteins and macromolecules such as Hyaluronic Acid is reduced, the epidermis becomes thinner and dermal and epidermal functions are disrupted.
- General Information
- Recommended formulation temperature: 35-40°C
- pH of the aqueous solution (2% powder): 3.5 to 4.5
- Storage: between 15°C and 25°C, in a hermetically sealed bag, away from light and humidity
- Patents: FR2005/01076, 29/04/2005 - WO2
Applications & Uses
- Markets
- Color Cosmetic Applications
- Skin Care Applications
- Use Level
- 0.1% to 0.6%
Properties
- Odor
- Characteristic
- Appearance
- Powder
- Soluble in
- Water
Regulatory & Compliance
- Certifications & Compliance
Technical Details & Test Data
- Efficacy Study
Effectiveness ex-vivo
Moisture redensification of the epidermis and dermis
By trapping water (up to 1,000 times its molecular weight), Hyaluronic Acid makes the skin supple, giving it a plumped, smooth appearance. Over time, and especially under the effect of oxidative stress, its quantity decreases significantly. As a result, the skin (particularly the epidermis) loses volume.
An emulsion containing 0.6% EFFIPULP® was applied on skin explants vs a placebo (one application every 24 hours for 72 hours). Hyaluronic Acid is marked by immunofluorescence (green) and quantified by image analysis.
Immunofluostaining of Hyaluronic Acid (HA) (green: HA - red: nucleous)
Effipulp® stimulates endogenous synthesis of key hygroscopic molecules of the epidermis and dermis, such as Hyaluronic Acid.
In addition, EFFIPULP® stimulates the synthesis of Filaggrin and Transglutaminase (cornified envelope), two compounds essential for proper cohesion and resistance of the stratum corneum. Thus, EFFIPULP® preserves the moisture content of the skin.
- Clinical study
Plumping Effect of Effipulp®
One of the main signs of skin aging is the thinning of the epidermis. A clinical study comparing two populations (average age: 22.5 vs 55.3) revealed, via OCT* measurement, average thinning of the facial epidermis of 8.4%.
Comparative, randomized study, double-blind vs. placebo
49 women (average age: 49) with dry, sensitive skin, divided into two groups, applied a cream to their faces, one containing 0.6% Effipulp® and the other a placebo. Study term: 56 days, with two applications daily.
The plumping effect was assessed by quantifying the variation in epidermal volume using the OCT* technique, which reconstructs the epidermis in 3D via very-high-resolution images. *(Optical Coherence Tomography)
Results (/T0):
• placebo: no significant effect.
• cream with 0.6% EFFIPULP®: +6.1% significant increase in epidermis volume.
