Knowde Enhanced TDS
Identification & Functionality
- INCI Name
- Ingredient Origin
- Cosmetic Ingredients Functions
- CAS No.
- 97676-26-1
- Technologies
- Product Families
Features & Benefits
- Benefit Claims
- Labeling Claims
- Product Background
PASSIOLINE® is an unsaponifiables concentrate (notably tocotrienols) produced by a patented molecular distillation process from Maracuja Oil. At the same time the oil is produced, the seeds are doubly valuated by the production of an anti-pollution active ingredient (ORMESIA®).
PASSIOLINE® takes care of damaged and weakened skin Unsightly skin lesions are a regular part of our daily lives. These include chapping, irritations, acne, burns, cuts and post-surgery. Damaged skin activates a healing process to return to its original condition. This process has two key phases: the repair and the regeneration of tissues. PASSIOLINE® stimulates the key markers involved in skin repair and remodeling to promote and improve the healing process.
Healing is a complex process that involves multiple steps, two of which are key for skin tissues:
• REPAIR, enabling tissues to be quickly restored at three levels. In addition to the cell proliferation that is vital for tissue recovery, the following markers are involved:
- Hyaluronic acid: an essential component of the different stages of healing, promoting cell migration and reepithelialisation in particular.
- Perlecan: proteoglycan and essential DEJ constituent protein, along with fibronectin, playing an important role in stabilization and adhesion of cells to the matrix.
• REMODELING OR REGENERATION to restore tissues integrity and mechanical properties. The following markers are involved:
- Elastin: needed to rebuild and provide elasticity to the matrix while regenerating.
- Fibromodulin, lumican: protoglycans involved in the assembly and structural organization of collagen fibers, as well as in regulating the contractile forces of fibroblasts.
- General Information
• Recommended formulation temperature: up to 50°C
• Storage conditions: away from light, under nitrogen atmosphere in a hermetically sealed container, between 15°C and 25°C
• Patent(s): WO2015044254, 02/04/2015
Applications & Uses
- Markets
- Application Format
- Skin Care Applications
- Sun Care Applications
- Treatment Product Applications
- Use Level
- 0.5-1%
- Recommended Uses
• Repairing skin care, helps wound healing
• Skin care for weakened, damaged and very dry skin
• Regenerative and restructuring skin care (anti-aging or post-surgery)
• Soothing skin care, after-sun care
Properties
- Physical Form
Regulatory & Compliance
- Certifications & Compliance
Technical Details & Test Data
- Efficacy Study
1 - Repairing effect at three levels: dermis, DEJ, epidermis PASSIOLINE® stimulates the key markers involved in the skin repair mechanisms, the first step in healing.
2 - Regenerating, remodeling, restructuring effect PASSIOLINE® stimulates the key markers involved in the reorganization of the ECM, enabling tissues to be properly remodeled and mechanical skin properties to be restored following a lesion.
All of these markers play a key role in counteracting the effects of skin aging.
- Clinical study
Repairing, regenerating & soothing effect
Double-blind,randomized study including a dermabrasion procedure. Comparative study with a commercial repairing cream selected among the market leaders.
• 48 women (age ≥ 18), divided into two groups after a superficial dermabrasion
• Each group applied a cream twice daily for 14 days: either 1% PASSIOLINE® or the commercial cream
• Repairing and soothing effects measured (TEWL and microcirculation)
• PASSIOLINE® is as effective as the commercial cream in terms of TEWL and microcirculation throughout the study: D3, D7 and D14.
• PASSIOLINE® has a repairing effect: from D3 there is a significant reductionintheTEWLcomparedtothepost-dermabrasioncondition.
• PASSIOLINE ® has a soothing effect: from D3 there is a significant reduction in microcirculation compared to the postdermabrasion condition.
• PASSIOLINE® enabled the TEWL to return to its original level by D14 and microcirculation from D3.
Perceived effectiveness of PASSIOLINE® : self-evaluation after 14 days
• Soothes the visible effects of dermabrasion
• Soothes the visible redness from dermabrasion
• Soothes discomfort from dermabrasion
- Fatty acids composition
Fatty acids Composition Palmitic acid 5.0 to 15% Palmitoleic acid max.1.0% Stearic acid max.5.0% Oleic acid 10.0 to 2.0% Linoleic acid 60.0 to 80.0% Linolenic acid max.1.0% Arachidic acid max.1.0% Gadoleic acid max.1.0% Behenic acid max.1.0% Lignoceric acid max.1.0%