Glycacil® 2000

Glycacil® 2000 is a water soluble preservative variant of iodopropynyl butylcarbamate that offers strong efficacy against yeasts and molds. This preservative is globally approved for rinse-off and leave-on products, has a strong safety profile, is temperature stable, and is compatible with commonly used ingredients such as cationic, anionic, nonionic surfactants, emulsifiers and proteins.

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Technical data sheet (TDS)
Product brochure
See all documents (3)


Features And Benefits
Wide global acceptance
Effective at low levels
Highly effective antifungal
Broad pH applicability
Compatible with a broad range of personal care ingredients
Convenient Water-soluble solution
Remarkably efficient in inhibiting growth of yeast and mold
Ingredient Claims
End Use Claims
Regional Availability
North America
Regulatory Status
China Compliant
Product Characteristics
Physical Form
Formulation Conditions
Use Level
Soluble in
Application pH Range

Knowdz for Glycacil® 2000

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End uses

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Technical product information

Key Attributes
  • Highly effective fungicide; remarkably efficient in inhibiting
    growth of yeast and mold
  • Has a wide range of global regulatory approval
  • Water-soluble
  • Temperature stable
  • Compatible with commonly used ingredients such as cationic,
  • anionic, nonionic surfactants, emulsifiers and proteins
  • Convenient form provides easier handling
  • Low use levels for efficac
Compositional Breakdown

  • Anhydrous
  • Baby care (rinse-off only)
  • Body wash
  • Conditioner
  • Cream
  • Deo/ Anti-perspirant
  • Eye creams/gels
  • Eye shadow
  • Face lotion
  • Face wipes
  • Facial cream
  • Foundation
  • Hair gel
  • Hand soap
  • Lotion
  • Make up remover
  • Mascara
  • Oil in Water
  • Powder
  • Shampoo
  • Toner
  • Water in Oil

Microbiological Challenge Studies Studies were run using various concentrations of Glycacil® 2000 in various formulations to see efficacy on a mixed inoculum of fungi. All samples were inoculated at the beginning of the study, sampled at 24 hours, 3, 7, 14, 21 and 28 days.

Efficacy of Shampoo Formula

Shampoo Formula

Efficacy of Cream Formula

Cream Formula

Comparative Fungicidal Activity of Glycacil® 2000 to Parabens

The focused fungicidal activity of the IPBC in Glycacil® 2000 leads to greater efficacy and lower usage levels versus competitive chemistries.

Mix fungi: A.niger ATCC#16404 + C.albicans ATCC#10231

% of preservative (as supplied) required to achieve < 10 cfu/ml. of the mix fungi in anionic shampoo

Global Regulatory


  • Approved under Annex V to Regulation EC/1223/2009
  • Allowed in rinse-off products up to 0.02% IPBC and up to 0.01% IPBC in leave-on products except in creams and lotions aimed to be applied on a large part of the body
  • Allowed for use in antiperspirants/deodorants up to 0.0075% IPBC
  • Not allowed for oral hygiene and lip products or in preparations for children under the age of 3 except in rinse-off applications


  • Listed in the positive list. Can be used at a level up to 0.02% IPBC in leave-on and rinse-off products

United States

  • Approved by CTFA for both rinse-off and leave-on applications.
    Maximum use level of 0.1% for IPBC
Formulation Recommendations
  • Soluble in water up to 95% allowing for wider formulation flexibility
  • Fully compatible with a wide variety of formulations as well as all types of cationic, nonionic and anionic systems
  • Can be added virtually anywhere in the manufacturing process
  • Can be added at both room and elevated temperatures as high as 50°C for as long as 6 hours without loss of efficacy
  • Wide pH range: 2–10
  • Can be inactivated by strong reducing agents, acids and bases
  • Typically needs to be used in combination with a bactericide
  • DMDMH (Glydant® products), phenoxyethanol, CMI/MI (Isocil® products) or other bactericide can be used
  • Formulator to confirm that there are no patent issues
  • Glycacil® 2000 is freeze/thaw/heat stable without phase separation or crystal formation through several cycles
  • Glycacil® 2000 shows significant improvement in both activity retention and resistance to color development versus
  • solvent-based IPBC products (see below)
Formulation Recommendations: activity retention and resistance to color development versus solvent-based IPBC products

Other Products within this Brand (2)

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Branded product

Glycacil® L

INCIs: Iodopropynyl Butylcarbamate

Categories: Microbial Control & Preservation

412 Mt. Kemble Avenue
Morristown, NJ 07960
United States