Lonza
Glydant Plus® Liquid
Glydant Plus® Liquid is a synergistic preservation system that combines two well-known and traditional chemistries for personal care. The combination of DMDM Hydantoin and Iodopropynyl Butylcarbamate allow for a dual mode of action, offering broad spectrum efficacy. These chemistries been used in personal care for years. This product contains the same amount of active ingredient as Lonza’s Glydant Plus® but is offered as a liquid form.
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Features And Benefits
Summary
Cost-effective
Compatible with a broad range of personal care ingredients
Ultra-low free formaldehyde (<0.1%)
Synergistic combination of two welltrusted preservatives
Broad spectrum protection
Regional Availability
North America
Europe
Asia Pacific
Ingredient Claims
Non-GMO
End Use Claims
Preservation
Regulatory Status
China Compliant
Certifications
Halal
Product Characteristics
Origin
Chemical Synthesis
Physical Form
Liquid
Color
Clear
Formulation Conditions
Use Level
0.15-0.36%
Soluble in
Water
Application pH Range
2–10
Technical product information
Key Attributes
- Highly cost-effective use level
- Stable in sunlight and over a wide range of temperatures and pH
- Low free formaldehyde and improved toxicology profile
- Compatible with virtually all raw materials used in personal care formulations
- Low odor
- Liquid product, water soluble
- Ease of use, no pre-mixing
- Patented blend of DMDMH and IPBC
- Synergistic, broad spectrum mode of action: no need for auxiliary preservatives
- Has a wide range of global regulatory acceptance
Compositional Breakdown
Applications
- Anhydrous
- Baby care (rinse-off only)
- Body wash
- Conditioner
- Cream
- Deo / Anti-perspirant
- Eye creams/gels
- Eye shadow
- Face lotion
- Face wipes
- Facial cream
- Foundation
- Hair gel
- Hand soap
- Lotion
- Make up remover
- Mascara
- Oil in Water
- Powder
- Shampoo
- Suncare
- Toner
- Water in Oil
Efficacy
Microbiological Challenge Studies
Studies were run using different concentrations of Glydant Plus® Liquid in various formulations to see efficacy against various bacteria, yeast and fungi. All samples were inoculated at the beginning of the study, sampled at 24 hours, 3, 7, 14, 21 and 28 days.
GMS Cream
Test Results
Shampoo Formulation
Test Results
Test Results
- Commercially available blend of 72% Phenoxyethanol + 17% Methylparabens
+ 2% Ethylparabens + 2% Propylparabens - Commercially available blend of 73% Benzyl alcohol + 18% Methylparabens + 9% Propylparabens
- Commercially available blend of 70% Phenoxyethanol + 15% Methylparabens
+ 5% Isopropylparabens + 5% Isobutylparabens + 5% Butylparabens
*P. aeruginosa ATCC #9027, S. aureus ATCC #6538, E. coli ATCC #8739
Test Results
- Commercially available blend of 72% Phenoxyethanol + 17% Methylparabens
+ 2% Ethylparabens + 2% Propylparabens - Commercially available blend of 73% Benzyl alcohol + 18% Methylparabens + 9% Propylparabens
- Commercially available blend of 70% Phenoxyethanol + 15% Methylparabens
+ 5% Isopropylparabens + 5% Isobutylparabens + 5% Butylparabens
*A. Niger ATCC #16404, C. albicans ATCC #10231
Formulation Recommendations
- Can be added at both room and elevated temperatures as high as 60°C for 2–3 hours
- At high temperatures, mixing should be carried out in a closed vessel
- Wide pH range: 3–10
- Readily soluble in any aqueous phase, as well as in polar organic solvents like alcohols, glycols, glycol esters, alkyl sulfates, amphoterics, and alkanolamides
- Compatible with virtually all raw materials used in personal care formulations including anionic, cationic and nonionic surfactants, thickening agents, chelating agents, colors and fragrances
Additional Information
Viscosity, pH, Color and Homogeneity
A stability study has been conducted by adding 0.3% Glydant Plus® Liquid in a broad variety of personal care products, and by checking viscosity, pH, color and homogeneity of the end products after one month at room temperature and 50°C. Glydant Plus® Liquid proved to be compatible with all of the tested products. No major change was observed for either criteria.
Water-white to light yellow color of Glydant Plus® Liquid is stable when stored at 23°C.
Glydant Plus® Liquid homogeneous phase is stable when stored at 23°C. After storage of three months at 40°C, one month at 50°C and three months exposure to sunlight, Glydant Plus® Liquid maintains its homogeneity.
Glydant Plus® Liquid Solubility & Compatibility Characteristics
Typical % Free HCHO level
Global Regulatory
Europe
- Both active ingredients approved, Annex V to Regulation EC/1223/2009.
- Finished products containing DMDMH must be labeled with the warning “contains formaldehyde” if the (free) formaldehyde concentration exceeds 0.05%
- Max use level: 0.6% DMDMH and 0.01% IPBC (leave-on except in creams and lotions aimed to be applied on a large part of the body), 0.6% DMDMH and 0.02% IPBC (rinse-off). Allowed in rinseoff products up to 0.02% IPBC and up to 0.01% IPBC
- Not allowed for oral and lip products
- Cannot be used in products for children under three years (except for rinse-off)
Japan
- Listed in the positive list. The following warning must be labeled: “should not be used by infants or by people who are hypersensitive to formaldehyde.”
- Cannot be used in leave-on due to DMDMH
- Max use level: 0.3% DMDMH and 0.02% IPBC for rinse-off
- Not permitted in oral care
USA
- Approved by CTFA for both rinse-off and leave-on applications
- Max use level of 0.6% DMDMH and 0.01% IPBC
General
- Not for use in oral and lip care
Glydant Plus® Liquid
412 Mt. Kemble Avenue
Morristown, NJ 07960
United States
