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Glydant Plus® Liquid
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Glydant Plus® Liquid

Glydant Plus® Liquid is a synergistic preservation system that combines two well-known and traditional chemistries for personal care. The combination of DMDM Hydantoin and Iodopropynyl Butylcarbamate allow for a dual mode of action, offering broad spectrum efficacy. These chemistries been used in personal care for years. This product contains the same amount of active ingredient as Lonza’s Glydant Plus® but is offered as a liquid form.
Product Resources

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Identification & Functionality

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Compositional Breakdown
Chemical Compound Breakdown Cas No. EINECS No.
DMDM Hydantoin 6440-58-0 229-222-8
Butane-1,3-diol 107-88-0 203-529-7
3-iodo-2-propynyl butylcarbamate 55406-53-6 259-627-5
Water 7732-18-5 231-791-2

 

Chemical Compound Breakdown Percentage
DMDMH range 64–72%*
Butane-1,3-diol 5% min
IPBC 2.2-2.8%
Water 22.0–26.0 %

*Note : This is the DMH + Formaldehyde solids content.
Glydant Plus® Liquid does not use the 2:1 ratio Formaldehyde to DMH.

Features & Benefits

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Benefit Claims
Labeling Claims
Origin
Chemical Synthesis
Key Attributes
  • Highly cost-effective use level
  • Stable in sunlight and over a wide range of temperatures and pH
  • Low free formaldehyde and improved toxicology profile
  • Compatible with virtually all raw materials used in personal care formulations
  • Low odor
  • Liquid product, water soluble
  • Ease of use, no pre-mixing
  • Patented blend of DMDMH and IPBC
  • Synergistic, broad spectrum mode of action: no need for auxiliary preservatives
  • Has a wide range of global regulatory acceptance

Applications & Uses

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Use Level
0.15-0.36%
Application pH Range
2–10
Applications
  • Anhydrous
  • Baby care (rinse-off only)
  • Body wash
  • Conditioner
  • Cream
  • Deo / Anti-perspirant
  • Eye creams/gels
  • Eye shadow
  • Face lotion
  • Face wipes
  • Facial cream
  • Foundation
  • Hair gel
  • Hand soap
  • Lotion
  • Make up remover
  • Mascara
  • Oil in Water
  • Powder
  • Shampoo
  • Suncare
  • Toner
  • Water in Oil
Formulation Recommendations
  • Can be added at both room and elevated temperatures as high as 60°C for 2–3 hours
  • At high temperatures, mixing should be carried out in a closed vessel
  • Wide pH range: 3–10
  • Readily soluble in any aqueous phase, as well as in polar organic solvents like alcohols, glycols, glycol esters, alkyl sulfates, amphoterics, and alkanolamides
  • Compatible with virtually all raw materials used in personal care formulations including anionic, cationic and nonionic surfactants, thickening agents, chelating agents, colors and fragrances

Properties

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Ingredient Origin
Physical Form
Physical Form
Liquid
Color
Clear
Soluble in
Water
Glydant Plus® Liquid Solubility & Compatibility Characteristics
General Class Specific Example
Water Water Soluble
Alcohols Ethanol Soluble
Glycols Propylene Glycol Soluble
Alkyl Sulfates Sodium Lauryl Sulfate Compatible
Quaternized Compounds Dicetyl Dimethyl Ammonium Chloride Compatible
Amphoterics Cocoamidopropyl Betaine Compatible
Glycol Esters PEG-4 Laurate Compatible
Alkanolamide Cocamide DEA Compatible

Regulatory & Compliance

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Certifications & Compliance
Global Regulatory

Europe

  • Both active ingredients approved, Annex V to Regulation EC/1223/2009.
  • Finished products containing DMDMH must be labeled with the warning “contains formaldehyde” if the (free) formaldehyde concentration exceeds 0.05%
  • Max use level: 0.6% DMDMH and 0.01% IPBC (leave-on except in creams and lotions aimed to be applied on a large part of the body), 0.6% DMDMH and 0.02% IPBC (rinse-off). Allowed in rinseoff products up to 0.02% IPBC and up to 0.01% IPBC
  • Not allowed for oral and lip products
  • Cannot be used in products for children under three years (except for rinse-off)

Japan

  • Listed in the positive list. The following warning must be labeled: “should not be used by infants or by people who are hypersensitive to formaldehyde.”
  • Cannot be used in leave-on due to DMDMH
  • Max use level: 0.3% DMDMH and 0.02% IPBC for rinse-off
  • Not permitted in oral care

USA

  •  Approved by CTFA for both rinse-off and leave-on applications
  •  Max use level of 0.6% DMDMH and 0.01% IPBC

 General 

  •  Not for use in oral and lip care

Technical Details & Test Data

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Efficacy

Microbiological Challenge Studies
Studies were run using different concentrations of Glydant Plus® Liquid in various formulations to see efficacy against various bacteria, yeast and fungi. All samples were inoculated at the beginning of the study, sampled at 24 hours, 3, 7, 14, 21 and 28 days.

GMS Cream
Ingredients(all unpreserved) % wt/wt
Glyceryl monostearate 6.0%
POE 20 glyceryl monostearate 4.0%
Cetearyl alcohol 1.5%
Myristyl propionate 8.0%
Glycerin 5.0%
Sterile DI water 75.5%
Total 100%
Percentage of Glydant Plus® Liquid required to achieve <10 cfu/g of mix inocula in the GMS cream
  Glydant Plus® Liquid Competitor A Competitor B Competitor C Competitor D
Bacteria1
Day7 0.15 0.2 0.3 >0.6 >0.8
Day14 0.15 0.2 0.4 >0.6 <0.8
Day21 0.15 0.2 0.3 >0.6 <0.8
Day28 0.15 0.2 0.3 >0.6 <0.8
Fungi2
Day7 0.2 >0.8 >0.8 >0.6 >1.0
Day14 0.2 0.8 >0.8 >0.6 >0.8
Day21 0.2 0.8 >0.8 >0.6 >0.8
Day28 0.2 0.8 >0.8 >0.6 >0.8

 

1 Mix inoculum of bacteria consists of E.coli, P.aeruginosa and S.aureus.
2 Mix inoculum of fungi consists of C.albicans and A.niger.
NT = Not Tested

Competitor A: commercially available blend containing 60% Propylene Glycol + 39.6% Diazolidinyl Urea + 0.4% IPBC.

Competitor B: commercially available blend containing 56% Propylene Glycol + 30% Diazolidinyl Urea + 11% Methylparabens + 3% Propylparabens.

Competitor C: 0.4% Methylparabens + 0.2% Propylparabens.

Competitor D: commercially available blend containing 70% Phenoxyethanol + 15% Methylparabens + 5% Isopropylparabens + 5% Isobutylparabens + 5% Butylparabens.

Shampoo Formulation
Ingredients % wt/wt
Sodium lauryl ether sulfate 35.0%
Triethanolamine laurylsulfate 25.0%
Cocamide DEA 3.0%
Anhydrous protein 1.0%
Sterile DI water 36.0%
Total 100.0%
Percentage of Glydant Plus® Liquid required to achieve <10 cfu/g of mix inocula in the Shampoo
  Glydant Plus® Liquid Competitor C Competitor D
Bacteria1
Day7 0.1 NT NT
Day14 0.1 NT NT
Day21 0.1 NT NT
Day28 0.1 NT NT
Fungi2
Day7 0.1 >0.6 >0.8
Day14 0.1 >0.6 >0.8
Day21 0.1 >0.6 >0.8
Day28 0.1 >0.6 >0.8

 

1 Mix inoculum of bacteria consists of E.coli, P.aeruginosa and S.aureus.
2 Mix inoculum of fungi consists of C.albicans and A.niger.
NT = Not Tested

Competitor A: commercially available blend containing 60% Propylene Glycol + 39.6% Diazolidinyl Urea + 0.4% IPBC.

Competitor B: commercially available blend containing 56% Propylene Glycol + 30% Diazolidinyl Urea + 11% Methylparabens + 3% Propylparabens.

Competitor C: 0.4% Methylparabens + 0.2% Propylparabens.

Competitor D: commercially available blend containing 70% Phenoxyethanol + 15% Methylparabens + 5% Isopropylparabens + 5% Isobutylparabens + 5% Butylparabens.

Percentage of Glydant Plus® Liquid required to achieve <10 cfu/g of mixed bacteria* in a Non-ionic Cream

Lonza Glydant Plus Liquid Percentage of Glydant Plus Liquid required to achieve <10 cfu/g of mixed bacteria* in a Non-ionic Cream

  • Commercially available blend of 72% Phenoxyethanol + 17% Methylparabens
    + 2% Ethylparabens + 2% Propylparabens
  • Commercially available blend of 73% Benzyl alcohol + 18% Methylparabens + 9% Propylparabens
  • Commercially available blend of 70% Phenoxyethanol + 15% Methylparabens
    + 5% Isopropylparabens + 5% Isobutylparabens + 5% Butylparabens

*P. aeruginosa ATCC #9027, S. aureus ATCC #6538, E. coli ATCC #8739

Percentage of Glydant Plus® Liquid required to achieve <10 cfu/g of mixed fungi* in a Non-ionic Cream

Lonza Glydant Plus Liquid Percentage of Glydant Plus Liquid required to achieve <10 cfu/g of mixed fungi* in a Non-ionic Cream

  • Commercially available blend of 72% Phenoxyethanol + 17% Methylparabens
    + 2% Ethylparabens + 2% Propylparabens
  • Commercially available blend of 73% Benzyl alcohol + 18% Methylparabens + 9% Propylparabens
  • Commercially available blend of 70% Phenoxyethanol + 15% Methylparabens
    + 5% Isopropylparabens + 5% Isobutylparabens + 5% Butylparabens

*A. Niger ATCC #16404, C. albicans ATCC #10231

Additional Information
% total HCHO % IPBC
Time (months) 23°C 40°C 50°C 23°C 40°C 50°C
1 100 100 100 100 100 > 90
3 100 > 95 NT > 90 > 95 NT
12 > 95 NT NT > 95 NT NT
18 > 95 NT NT > 90 NT NT
Viscosity, pH, Color and Homogeneity

A stability study has been conducted by adding 0.3% Glydant Plus® Liquid in a broad variety of personal care products, and by checking viscosity, pH, color and homogeneity of the end products after one month at room temperature and 50°C. Glydant Plus® Liquid proved to be compatible with all of the tested products. No major change was observed for either criteria.

Water-white to light yellow color of Glydant Plus® Liquid is stable when stored at 23°C.

Glydant Plus® Liquid homogeneous phase is stable when stored at 23°C. After storage of three months at 40°C, one month at 50°C and three months exposure to sunlight, Glydant Plus® Liquid maintains its homogeneity.

Typical % Free HCHO level
  % Free HCHO
Glydant Plus® Liquid < 0.1%
Competitor A > 1.0%
Competitor B > 1.0%

Packaging & Availability

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Documents (4)

Document Name
Type
Products
Technical Data Sheet
Glydant Plus® Liquid
Technical Data Sheet
Products: Glydant Plus® Liquid
Brochure
Aldo® PGHMS Kfg, Carnipure® Crystalline, Cosmocil® CQ, Geogard Ultra®, Glycacil® L, Glydant®, Glydant® 2000, Glydant Plus® Liquid, LaraCare® A200, Lonza Niacinamide USP PC, Glycomul® S KFG, Glycomul® TS KFG, Glycosperse® L-20 KFG, Glycosperse® O-20 KFG, Glycosperse® S-20 KFG, Glycosperse® TS-20 KFG, VANTOCIL™ IB Antimicrobial, SYNETH™ O3 K RSPO MB, SYNETH™ S7 K RSPO MB Pastille, SYNETH™ S8 K RSPO MB Pastille, SYNETH™ S10 K RSPO MB Pastille, SYNETH™ P11 K RSPO MB Pastille, SYNETH™ O13 K RSPO MB, SYNETH™ C15 K RSPO MB, SYNETH™ L15 K RSPO MB, Cosmocil® PG Antimicrobial, VANTOCIL™ TG Antimicrobial, Glydant® Plus
Brochure
Products: Aldo® PGHMS Kfg, Carnipure® Crystalline, Cosmocil® CQ, Geogard Ultra®, Glycacil® L, Glydant®, Glydant® 2000, Glydant Plus® Liquid, LaraCare® A200, Lonza Niacinamide USP PC, Glycomul® S KFG, Glycomul® TS KFG, Glycosperse® L-20 KFG, Glycosperse® O-20 KFG, Glycosperse® S-20 KFG, Glycosperse® TS-20 KFG, VANTOCIL™ IB Antimicrobial, SYNETH™ O3 K RSPO MB, SYNETH™ S7 K RSPO MB Pastille, SYNETH™ S8 K RSPO MB Pastille, SYNETH™ S10 K RSPO MB Pastille, SYNETH™ P11 K RSPO MB Pastille, SYNETH™ O13 K RSPO MB, SYNETH™ C15 K RSPO MB, SYNETH™ L15 K RSPO MB, Cosmocil® PG Antimicrobial, VANTOCIL™ TG Antimicrobial, Glydant® Plus
Brochure
Cosmocil® CQ, Geogard® 111A, Geogard® 111S, Geogard® 221, Geogard® ECT, Geogard® LSA, Geogard Ultra®, Glycacil® 2000, Glycacil® L, Glydant®, Glydant® 2000, Glydant® LTD, Glydant Plus® Liquid, Isocil® PC, Lonzagard® Benzethonium Chloride, Lonzaserve® PC, Mikrokill® COS, Spectradyne™, Glydant® Plus
Brochure
Products: Cosmocil® CQ, Geogard® 111A, Geogard® 111S, Geogard® 221, Geogard® ECT, Geogard® LSA, Geogard Ultra®, Glycacil® 2000, Glycacil® L, Glydant®, Glydant® 2000, Glydant® LTD, Glydant Plus® Liquid, Isocil® PC, Lonzagard® Benzethonium Chloride, Lonzaserve® PC, Mikrokill® COS, Spectradyne™, Glydant® Plus
Brochure
Aldo® MSD Kfg, Aldo® PGHMS Kfg, Amphoterge® K-2, Amphoterge® K-J-2-50%, Amphoterge® W, Amphoterge® W-2, Biocell™ SOD, Carnipure® Crystalline, Carnipure® Tartrate, Carsoquat® 450i, Carsoquat® CT-429, Carsoquat® SDQ-25, Carsoquat® SDQ-85, Cosmocil® CQ, Geogard® 111A, Geogard® 111S, Geogard® 221, Geogard® ECT, Geogard® LSA, Geogard Ultra®, Glycacil® 2000, Glycacil® L, Glydant®, Glydant® 2000, Glydant® LTD, Glydant Plus® Liquid, Isocil® PC, LaraCare® A200, Lonza Gel Base BSM5, Lonza Marula Oil, Lonza Niacinamide USP PC, Lonzagard® Benzethonium Chloride, Lonzaserve® PC, Lonzest® GDL, Lonzest® GMO, Lonzest® GMS-C, Lonzest® GMS-D, Lonzest® MSA, Lonzest® SML, Lonzest® SMO, Lonzest® SOC, Lonzest® STO, Metabiotics® Resveratrol ECT GEO, Mikrokill® COS, NAB® Butterbur Extract, NAB® Rhodiola Extract, Natrulon® H-10, Natrulon® H-6, Pegosperse® 100-S, Pegosperse® 1500 MS, Pegosperse® 400 DL, Pegosperse® 400 DS VEG, Pegosperse® 400 ML, Pegosperse® 50 DS, Pegosperse® 50 MS, SeaPure® Agarose, Solu-Mar® Elastin SD, Spectradyne™, ViscUp® 160, Vitazyme® A Plus, Zinc Omadine® 48% FPS Cosm Grade, Ethosperse® LA-23, Ethosperse® LA-4, Glycomul® S KFG, Glycomul® TS KFG, Glycosperse® L-20 KFG, Glycosperse® O-20 KFG, Glycosperse® S-20 KFG, Glycosperse® TS-20 KFG, Metabiotics® Resveratrol, ScreenLight® Block, Pegosperse® 400 DS Special, SYNETH™ O3 K RSPO MB, SYNETH™ S7 K RSPO MB Pastille, SYNETH™ S8 K RSPO MB Pastille, SYNETH™ S10 K RSPO MB Pastille, SYNETH™ P11 K RSPO MB Pastille, SYNETH™ O13 K RSPO MB, SYNETH™ C15 K RSPO MB, SYNETH™ L15 K RSPO MB, XPressEV™, H₂OBioEV®, Modifect® EV, PO.Fresh®, Glydant Plus®
Brochure
Products: Aldo® MSD Kfg, Aldo® PGHMS Kfg, Amphoterge® K-2, Amphoterge® K-J-2-50%, Amphoterge® W, Amphoterge® W-2, Biocell™ SOD, Carnipure® Crystalline, Carnipure® Tartrate, Carsoquat® 450i, Carsoquat® CT-429, Carsoquat® SDQ-25, Carsoquat® SDQ-85, Cosmocil® CQ, Geogard® 111A, Geogard® 111S, Geogard® 221, Geogard® ECT, Geogard® LSA, Geogard Ultra®, Glycacil® 2000, Glycacil® L, Glydant®, Glydant® 2000, Glydant® LTD, Glydant Plus® Liquid, Isocil® PC, LaraCare® A200, Lonza Gel Base BSM5, Lonza Marula Oil, Lonza Niacinamide USP PC, Lonzagard® Benzethonium Chloride, Lonzaserve® PC, Lonzest® GDL, Lonzest® GMO, Lonzest® GMS-C, Lonzest® GMS-D, Lonzest® MSA, Lonzest® SML, Lonzest® SMO, Lonzest® SOC, Lonzest® STO, Metabiotics® Resveratrol ECT GEO, Mikrokill® COS, NAB® Butterbur Extract, NAB® Rhodiola Extract, Natrulon® H-10, Natrulon® H-6, Pegosperse® 100-S, Pegosperse® 1500 MS, Pegosperse® 400 DL, Pegosperse® 400 DS VEG, Pegosperse® 400 ML, Pegosperse® 50 DS, Pegosperse® 50 MS, SeaPure® Agarose, Solu-Mar® Elastin SD, Spectradyne™, ViscUp® 160, Vitazyme® A Plus, Zinc Omadine® 48% FPS Cosm Grade, Ethosperse® LA-23, Ethosperse® LA-4, Glycomul® S KFG, Glycomul® TS KFG, Glycosperse® L-20 KFG, Glycosperse® O-20 KFG, Glycosperse® S-20 KFG, Glycosperse® TS-20 KFG, Metabiotics® Resveratrol, ScreenLight® Block, Pegosperse® 400 DS Special, SYNETH™ O3 K RSPO MB, SYNETH™ S7 K RSPO MB Pastille, SYNETH™ S8 K RSPO MB Pastille, SYNETH™ S10 K RSPO MB Pastille, SYNETH™ P11 K RSPO MB Pastille, SYNETH™ O13 K RSPO MB, SYNETH™ C15 K RSPO MB, SYNETH™ L15 K RSPO MB, XPressEV™, H₂OBioEV®, Modifect® EV, PO.Fresh®, Glydant Plus®

Formulations (3)

Formulation Name
End Uses
Product Families
Hair Care, Personal Care Formulations