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Isocil® PC
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Isocil® PC

Isocil® PC is a combination of two commonly used personal care preservatives, Methyl chloroisothiazolinone and Methylisothiazolinone (MI/CMI). These traditional preservatives have been used for years offering excellent broad spectrum efficacy at low use levels. With the added benefit of a strong safety profile as well as toxicological data, this chemistry is appealing amongst many formulators.
Product Resources

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Identification & Functionality

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Compositional Breakdown
Product Chemical Compound Breakdown Cas No. EINECS No.
Isocil® PC 5-Chloro-2-methyl-4- isothiazolin-3-one 26172-55-4 247-500-7
2-Methyl-4-isothiazolin3-one 2682-20-4 220-239-6
Magnesium Chloride 7786-30-3 232-094-6
Magnesium Nitrate 10377-60-3 233-826-7
Water 7732-18-5 231-791-2

 

Chemical Compound Breakdown %
5-Chloro-2-methyl-4-isothiazolin-3-one 1.15% min.
2-Methyl-4-isothiazolin-3-one 0.35% min.
Magnesium nitrate 21.0–25.0%
Magnesium chloride 0.4–0.8%
Water 73.8–78.2%

Features & Benefits

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Key Attributes
  • MI/CMI blend
  • Broad spectrum preservation
  • Easy to use liquid product
  • Compatible and soluble in most personal care raw materials
  • Cost effective
  • Clear liquid aqueous solution
  • Has a wide range of global regulatory approval
  • Traditional Efficacious Preservation
General Information

Not allowed for oral hygiene and lip products or in preparations for children under the age of 3

Applications & Uses

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Use Level
0.05-0.1% (Regional limits apply)
Application pH Range
3–9
Applications
  • Anhydrous
  • Baby care
  • Baby wipes
  • Body wash
  • Conditioner
  • Cream
  • Deo/ Anti-Perspirant
  • Eye creams/gel
  • Eye shadow
  • Face Lotion
  • Face wipes
  • Facial Cream
  • Foundation
  • Hair gel
  • Hand soap (non anti-bac)
  • Lotion
  • Make up remover
  • Mascara
  • Oil in Water
  • Powder
  • Shampoo
  • Suncare
  • Toner
  • Water in Oil
Formulation Recommendations
  • Miscible in water, glycols, most personal care solvents
  • Reducing agents, amines and strong nucleophiles will reduce activity of MCI/MI
  • Surfactants should be checked for residual bisulfite before addition
  • When used with amines, pH should be below 6 before addition
  • Should be added during the cool down phase of processing, at temperature of 50°C or below
  • Wide range pH: 3–9
  • Product pH (as is) is 3.0; should be handled with care due to acidity

Properties

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Physical Form
Physical Form
Liquid
Color
Clear
Odor
Mild
Soluble in
Water

Regulatory & Compliance

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Global Regulatory

Europe

  • Listed in Annex V to Regulation EC/1223/2009
  • Not permitted for leave-on products. Maximum use level of 0.0015 % CMI/MI for rinse-off applications

Japan

  • Listed in the positive list
  • Max use level of 0.01% CMI/MI for rinse-off
  • Not permitted in leave-on

US

  • Approved by PCPC for both rinse-off and leave-on applications
  • Max level of 0.00075% CMI/MI (7.5 ppm active ingredients) in leave-on products
  • Max level of 0.0015% CMI/MI (15 ppm active ingredients) in rinse-off products

Technical Details & Test Data

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Efficacy

Microbiological Challenge Studies
Studies were run using different concentrations of Isocil® PC in various formulations to see efficacy against various bacteria, yeast and fungi compared to other commercial isothiazolinones. All samples were inoculated at the beginning of the study, sampled at 24 hours, 3, 7, 10, 14, 21 and 28 days.

Shampooo Formula
Ingredient % wt/wt
CARSONOL_ SLES 35.0%
CARSONOL_ TLS 25.0%
CARSAMIDE_ CA 3.0%
Water (deionized) 36.0%
Polypro 5000 1.0%
Preservative q.s.
Total 100.0%
Isocil® PC vs. Competitive Isothiazolinone – Shampoo Mixed Inoculum-Bacteria*
CFU – Contact Time (Days)
Preservative % 0 1 3 7 10 14 28
None   7.1x10^6 3.4x10^6 9.0x10^6 3.4x10^7 4.2x10^7 3.4x10^7 2.3x107
Isocil® PC 0.05 5.5x10^6 3.1x10^4 3.0x10^3 <10 <10 <10 <10
Isocil® PC 0.10 7.8x10^6 7.8x10^4 3.0x10^3 <10 <10 <10 <10
Competitor 0.05 7.1x10^6 3.5x10^4 1.0x10^3 <10 <10 <10 <10
Competitor 0.10 6.1x10^6 5.0x10^4 2.0x10^3 <10 <10 <10 <10

* Mixed Inoculum consists of P. aeruginosa, S. aureus, and E. coli

Isocil® PC vs. Competitive Isothiazolinone – Shampoo Mixed Inoculum-Fungi**
CFU - Contact Time (Days)
Preservative % 0 1 3 7 10 14 28
None   8.0x10^5 3.0x10^5 6.0x10^5 4.0x10^5 3.0x10^5 3.0x10^5 3.0x10^5
Isocil® PC 0.05 1.0x10^6 2.2x10^4 3.0x10^3 <10 <10 <10 <10
Isocil® PC 0.10 9.0x10^5 3.3x10^4 3.0x10^3 <10 <10 <10 <10
Competitor 0.05 8.0x10^5 3.0x10^4 1.0x10^3 <10 <10 <10 <10
Competitor 0.10 8.0x10^5 1.3x10^4 2.0x10^3 <10 <10 <10 <10

*Mixed Inoculum consists of C.albicans and A. niger

Packaging & Availability

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Documents (3)

Document Name
Type
Products
Technical Data Sheet
Isocil® PC
Technical Data Sheet
Products: Isocil® PC
Brochure
Cosmocil® CQ, Geogard® 111A, Geogard® 111S, Geogard® 221, Geogard® ECT, Geogard® LSA, Geogard Ultra®, Glycacil® 2000, Glycacil® L, Glydant®, Glydant® 2000, Glydant® LTD, Glydant Plus® Liquid, Isocil® PC, Lonzagard® Benzethonium Chloride, Lonzaserve® PC, Mikrokill® COS, Spectradyne™, Glydant® Plus
Brochure
Products: Cosmocil® CQ, Geogard® 111A, Geogard® 111S, Geogard® 221, Geogard® ECT, Geogard® LSA, Geogard Ultra®, Glycacil® 2000, Glycacil® L, Glydant®, Glydant® 2000, Glydant® LTD, Glydant Plus® Liquid, Isocil® PC, Lonzagard® Benzethonium Chloride, Lonzaserve® PC, Mikrokill® COS, Spectradyne™, Glydant® Plus
Brochure
Aldo® MSD Kfg, Aldo® PGHMS Kfg, Amphoterge® K-2, Amphoterge® K-J-2-50%, Amphoterge® W, Amphoterge® W-2, Biocell™ SOD, Carnipure® Crystalline, Carnipure® Tartrate, Carsoquat® 450i, Carsoquat® CT-429, Carsoquat® SDQ-25, Carsoquat® SDQ-85, Cosmocil® CQ, Geogard® 111A, Geogard® 111S, Geogard® 221, Geogard® ECT, Geogard® LSA, Geogard Ultra®, Glycacil® 2000, Glycacil® L, Glydant®, Glydant® 2000, Glydant® LTD, Glydant Plus® Liquid, Isocil® PC, LaraCare® A200, Lonza Gel Base BSM5, Lonza Marula Oil, Lonza Niacinamide USP PC, Lonzagard® Benzethonium Chloride, Lonzaserve® PC, Lonzest® GDL, Lonzest® GMO, Lonzest® GMS-C, Lonzest® GMS-D, Lonzest® MSA, Lonzest® SML, Lonzest® SMO, Lonzest® SOC, Lonzest® STO, Metabiotics® Resveratrol ECT GEO, Mikrokill® COS, NAB® Butterbur Extract, NAB® Rhodiola Extract, Natrulon® H-10, Natrulon® H-6, Pegosperse® 100-S, Pegosperse® 1500 MS, Pegosperse® 400 DL, Pegosperse® 400 DS VEG, Pegosperse® 400 ML, Pegosperse® 50 DS, Pegosperse® 50 MS, SeaPure® Agarose, Solu-Mar® Elastin SD, Spectradyne™, ViscUp® 160, Vitazyme® A Plus, Zinc Omadine® 48% FPS Cosm Grade, Ethosperse® LA-23, Ethosperse® LA-4, Glycomul® S KFG, Glycomul® TS KFG, Glycosperse® L-20 KFG, Glycosperse® O-20 KFG, Glycosperse® S-20 KFG, Glycosperse® TS-20 KFG, Metabiotics® Resveratrol, ScreenLight® Block, Pegosperse® 400 DS Special, SYNETH™ O3 K RSPO MB, SYNETH™ S7 K RSPO MB Pastille, SYNETH™ S8 K RSPO MB Pastille, SYNETH™ S10 K RSPO MB Pastille, SYNETH™ P11 K RSPO MB Pastille, SYNETH™ O13 K RSPO MB, SYNETH™ C15 K RSPO MB, SYNETH™ L15 K RSPO MB, XPressEV™, H₂OBioEV®, Modifect® EV, PO.Fresh®, Glydant Plus®
Brochure
Products: Aldo® MSD Kfg, Aldo® PGHMS Kfg, Amphoterge® K-2, Amphoterge® K-J-2-50%, Amphoterge® W, Amphoterge® W-2, Biocell™ SOD, Carnipure® Crystalline, Carnipure® Tartrate, Carsoquat® 450i, Carsoquat® CT-429, Carsoquat® SDQ-25, Carsoquat® SDQ-85, Cosmocil® CQ, Geogard® 111A, Geogard® 111S, Geogard® 221, Geogard® ECT, Geogard® LSA, Geogard Ultra®, Glycacil® 2000, Glycacil® L, Glydant®, Glydant® 2000, Glydant® LTD, Glydant Plus® Liquid, Isocil® PC, LaraCare® A200, Lonza Gel Base BSM5, Lonza Marula Oil, Lonza Niacinamide USP PC, Lonzagard® Benzethonium Chloride, Lonzaserve® PC, Lonzest® GDL, Lonzest® GMO, Lonzest® GMS-C, Lonzest® GMS-D, Lonzest® MSA, Lonzest® SML, Lonzest® SMO, Lonzest® SOC, Lonzest® STO, Metabiotics® Resveratrol ECT GEO, Mikrokill® COS, NAB® Butterbur Extract, NAB® Rhodiola Extract, Natrulon® H-10, Natrulon® H-6, Pegosperse® 100-S, Pegosperse® 1500 MS, Pegosperse® 400 DL, Pegosperse® 400 DS VEG, Pegosperse® 400 ML, Pegosperse® 50 DS, Pegosperse® 50 MS, SeaPure® Agarose, Solu-Mar® Elastin SD, Spectradyne™, ViscUp® 160, Vitazyme® A Plus, Zinc Omadine® 48% FPS Cosm Grade, Ethosperse® LA-23, Ethosperse® LA-4, Glycomul® S KFG, Glycomul® TS KFG, Glycosperse® L-20 KFG, Glycosperse® O-20 KFG, Glycosperse® S-20 KFG, Glycosperse® TS-20 KFG, Metabiotics® Resveratrol, ScreenLight® Block, Pegosperse® 400 DS Special, SYNETH™ O3 K RSPO MB, SYNETH™ S7 K RSPO MB Pastille, SYNETH™ S8 K RSPO MB Pastille, SYNETH™ S10 K RSPO MB Pastille, SYNETH™ P11 K RSPO MB Pastille, SYNETH™ O13 K RSPO MB, SYNETH™ C15 K RSPO MB, SYNETH™ L15 K RSPO MB, XPressEV™, H₂OBioEV®, Modifect® EV, PO.Fresh®, Glydant Plus®