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Lonzagard® Benzethonium Chloride
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Lonzagard® Benzethonium Chloride

Lonzagard® Benzethonium Chloride USP is a unique, flexible quaternary ammonium-based antimicrobial compound that can be used as a personal care preservative. It offers greater efficacy, mildness, and safety versus competitive chemistries as an active antimicrobial ingredient. Lonzagard® Benzethonium Chloride USP is widely acceptable worldwide as a fast-acting preservative.
Product Resources

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Identification & Functionality

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Features & Benefits

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Origin
Chemical Synthesis
Key Attributes
  • Strong antibacterial
  • Not sensitizing
  •  Has a wide range of global regulatory acceptance
  • Water soluble
  • Light in color
  • Odorless
  • Can be used in a variety of personal care applications

Applications & Uses

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Use Level
0.1 – 0.5 %
Application pH Range
6–9
Applications
  • Baby care
  • Baby wipes
  • Body wash
  • Conditioner
  • Cream
  • Deo/ Anti-perspirant
  • Eye creams/gels
  • Eye shadow
  • Face lotion
  • Face wipes
  • Facial cream
  • Feminine hygiene
  • Foundation
  • Hand soap (non anti-bac)
  • Lipstick/gloss
  • Lotion
  • Make up remover
  • Mascara
  • Oil in Water
  • Oral care (as preservative, not the active)
  • Powder
  • Shampoo
  • Suncare
  • Toner
  • Water in Oil
Formulation Recommendations
  • Soluble in water, lower alcohols and glycols
  • Compatible with a wide variety of formulations as well as most types of cationic and non-ionic systems
  • It can be used effectively over a particularly wide pH range
  • Can be added at both room and elevated temperatures in any phase of production

Properties

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Ingredient Origin
Physical Form
Physical Form
Powder
Color
White
Odor
Odorless

Regulatory & Compliance

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Global Regulatory

Europe

  • Benzethonium chloride is approved, Annex V to Regulation EC/1223/2009
  • Max concentration of 0.1 %; not permitted for oral care

Japan

  • Japan = 0.5 % for rinse-off; 0.2 % for leave-on
  • Not permitted for contact with mucous membranes (eye, oral care, vaginal, etc.)

US

  • U.S. (CIR opinion)
  • 0.5 % for skin applications
  • 0.02 % for eye area

Technical Details & Test Data

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Efficacy

MICs were conducted on Lonzagard® Benzethonium Chloride USP for both bactericidal and bacteriostatic activity with results following.

MICs

Organism MIC (ppm)
Streptococcus pyogenes C-203 20
Streptococcus viridans 3
Escherichia coli 63
Salmonella gallinarum 31
Salmonella choleraesuis 31
Salmonella typhimurium 5
Salmonella schottmulleri 31
Pseudomonas aeruginosa PRD-10 125
Lactobacillus casei 10
Shigella sonnei 31
Klebsiella pheumoniae 5
Saccharomyces cerevisiae 10
Pityrosporumovale 1
Trichophyton mentagrophytes 25
Monilia albicans 1
Aspergillus niger 1250
Aspergillus oryzae 0.625
Penicillium notatum 1
Penicillium luteum 1
Microbiological Challenge Studies

A study was run on a formula using a 0.5% concentration of Lonzagard® Benzethonium Chloride USP. The protocol used was a PCPC challenge test. All samples were inoculated at the beginning of the study, sampled at 24 hours, 7, 14, 21 and 28 days. The samples were diluted in neutralizer and plated quantitatively for viable organisms at all sampling times. After 28 days, all samples were re-inoculated and subjected to a second challenge.

Lotion

pH: 5–5.5

Phase (A) % Phase (B) %
Water qs Hydroxyethylcellulose 1.5
Urea 5.00 - -
Sorbitan Monostearate 2.00 - -
Caprylic/ Capric Triglyceride 20.00 - -
PEG 1750 Monostearate 1.50 - -
Glyceryl Monostearate 2.00 - -
Decaglycerol Decaoleate 5.00 - -
Test Results
Test Organism Unpreserved Control Test – Lonzagard® Benzethonium Chloride USP (0.5%)
  Initial Challenge Re challenge Initial Challenge Re challenge
24 Hrs 1 Week 28 Days 28 Days 24 Hrs 1 Week 28 Days 28 Days
S. aureus 2.0 x 10^6 1.4 x 10^6 1.0 x 10^2 8.3x 10^2 <10 <10 <10 <10
K. pneumoniae + E. gergoviae 1.1 x 10^6 3.0 x 10^4 <10 <10 <10 <10 <10 <10
P. aeruginosa + B. cepacia 1.0 x 10^5 1.5 x 10^3 <10 3.0 x 10^5 <10 <10 <10 <10
C. albicans 6.9 x 10^4 3.0 x 10^1 <10 <10 <10 <10 <10 <10
Mixed Molds 5.8 x 10^4 3.2 x 10^4 1.5 x 10^4 2.5 x 10^4 1.0 x 10^2 1.0 x 10^1 <10 1.0 x 10^1

Packaging & Availability

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Regional Availability

Documents (3)

Document Name
Type
Products
Technical Data Sheet
Lonzagard® Benzethonium Chloride
Technical Data Sheet
Products: Lonzagard® Benzethonium Chloride
Brochure
Cosmocil® CQ, Geogard® 111A, Geogard® 111S, Geogard® 221, Geogard® ECT, Geogard® LSA, Geogard Ultra®, Glycacil® 2000, Glycacil® L, Glydant®, Glydant® 2000, Glydant® LTD, Glydant Plus® Liquid, Isocil® PC, Lonzagard® Benzethonium Chloride, Lonzaserve® PC, Mikrokill® COS, Spectradyne™, Glydant® Plus
Brochure
Products: Cosmocil® CQ, Geogard® 111A, Geogard® 111S, Geogard® 221, Geogard® ECT, Geogard® LSA, Geogard Ultra®, Glycacil® 2000, Glycacil® L, Glydant®, Glydant® 2000, Glydant® LTD, Glydant Plus® Liquid, Isocil® PC, Lonzagard® Benzethonium Chloride, Lonzaserve® PC, Mikrokill® COS, Spectradyne™, Glydant® Plus
Brochure
Aldo® MSD Kfg, Aldo® PGHMS Kfg, Amphoterge® K-2, Amphoterge® K-J-2-50%, Amphoterge® W, Amphoterge® W-2, Biocell™ SOD, Carnipure® Crystalline, Carnipure® Tartrate, Carsoquat® 450i, Carsoquat® CT-429, Carsoquat® SDQ-25, Carsoquat® SDQ-85, Cosmocil® CQ, Geogard® 111A, Geogard® 111S, Geogard® 221, Geogard® ECT, Geogard® LSA, Geogard Ultra®, Glycacil® 2000, Glycacil® L, Glydant®, Glydant® 2000, Glydant® LTD, Glydant Plus® Liquid, Isocil® PC, LaraCare® A200, Lonza Gel Base BSM5, Lonza Marula Oil, Lonza Niacinamide USP PC, Lonzagard® Benzethonium Chloride, Lonzaserve® PC, Lonzest® GDL, Lonzest® GMO, Lonzest® GMS-C, Lonzest® GMS-D, Lonzest® MSA, Lonzest® SML, Lonzest® SMO, Lonzest® SOC, Lonzest® STO, Metabiotics® Resveratrol ECT GEO, Mikrokill® COS, NAB® Butterbur Extract, NAB® Rhodiola Extract, Natrulon® H-10, Natrulon® H-6, Pegosperse® 100-S, Pegosperse® 1500 MS, Pegosperse® 400 DL, Pegosperse® 400 DS VEG, Pegosperse® 400 ML, Pegosperse® 50 DS, Pegosperse® 50 MS, SeaPure® Agarose, Solu-Mar® Elastin SD, Spectradyne™, ViscUp® 160, Vitazyme® A Plus, Zinc Omadine® 48% FPS Cosm Grade, Ethosperse® LA-23, Ethosperse® LA-4, Glycomul® S KFG, Glycomul® TS KFG, Glycosperse® L-20 KFG, Glycosperse® O-20 KFG, Glycosperse® S-20 KFG, Glycosperse® TS-20 KFG, Metabiotics® Resveratrol, ScreenLight® Block, Pegosperse® 400 DS Special, SYNETH™ O3 K RSPO MB, SYNETH™ S7 K RSPO MB Pastille, SYNETH™ S8 K RSPO MB Pastille, SYNETH™ S10 K RSPO MB Pastille, SYNETH™ P11 K RSPO MB Pastille, SYNETH™ O13 K RSPO MB, SYNETH™ C15 K RSPO MB, SYNETH™ L15 K RSPO MB, XPressEV™, H₂OBioEV®, Modifect® EV, PO.Fresh®, Glydant Plus®
Brochure
Products: Aldo® MSD Kfg, Aldo® PGHMS Kfg, Amphoterge® K-2, Amphoterge® K-J-2-50%, Amphoterge® W, Amphoterge® W-2, Biocell™ SOD, Carnipure® Crystalline, Carnipure® Tartrate, Carsoquat® 450i, Carsoquat® CT-429, Carsoquat® SDQ-25, Carsoquat® SDQ-85, Cosmocil® CQ, Geogard® 111A, Geogard® 111S, Geogard® 221, Geogard® ECT, Geogard® LSA, Geogard Ultra®, Glycacil® 2000, Glycacil® L, Glydant®, Glydant® 2000, Glydant® LTD, Glydant Plus® Liquid, Isocil® PC, LaraCare® A200, Lonza Gel Base BSM5, Lonza Marula Oil, Lonza Niacinamide USP PC, Lonzagard® Benzethonium Chloride, Lonzaserve® PC, Lonzest® GDL, Lonzest® GMO, Lonzest® GMS-C, Lonzest® GMS-D, Lonzest® MSA, Lonzest® SML, Lonzest® SMO, Lonzest® SOC, Lonzest® STO, Metabiotics® Resveratrol ECT GEO, Mikrokill® COS, NAB® Butterbur Extract, NAB® Rhodiola Extract, Natrulon® H-10, Natrulon® H-6, Pegosperse® 100-S, Pegosperse® 1500 MS, Pegosperse® 400 DL, Pegosperse® 400 DS VEG, Pegosperse® 400 ML, Pegosperse® 50 DS, Pegosperse® 50 MS, SeaPure® Agarose, Solu-Mar® Elastin SD, Spectradyne™, ViscUp® 160, Vitazyme® A Plus, Zinc Omadine® 48% FPS Cosm Grade, Ethosperse® LA-23, Ethosperse® LA-4, Glycomul® S KFG, Glycomul® TS KFG, Glycosperse® L-20 KFG, Glycosperse® O-20 KFG, Glycosperse® S-20 KFG, Glycosperse® TS-20 KFG, Metabiotics® Resveratrol, ScreenLight® Block, Pegosperse® 400 DS Special, SYNETH™ O3 K RSPO MB, SYNETH™ S7 K RSPO MB Pastille, SYNETH™ S8 K RSPO MB Pastille, SYNETH™ S10 K RSPO MB Pastille, SYNETH™ P11 K RSPO MB Pastille, SYNETH™ O13 K RSPO MB, SYNETH™ C15 K RSPO MB, SYNETH™ L15 K RSPO MB, XPressEV™, H₂OBioEV®, Modifect® EV, PO.Fresh®, Glydant Plus®