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Lonzaserve® PC
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Lonzaserve® PC

Lonzaserve® PC is a synergistic preservative system with dual broad spectrum activity for maximum preservation. It is effective against formaldehyde and isothiazolinone resistant organisms, Gram-positive and Gram-negative bacteria, fungi and yeast over a broad pH range. It is a colorless liquid with a very safe toxicology profile that is compatible for use in most personal care formulations.
Product Resources

Knowde Enhanced TDS

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Identification & Functionality

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Compositional Breakdown
Chemical Compound Breakdown CAS No. EINECS No.
DMDM Hydantoin 6440-58-0 229-222-8
Methylchloroisothiazolinone 26172-55-4 247-500-7
Methylisothiazolinone 2682-20-4 220-239-6
Water 7732-18-5 231-791-2

 

Chemical Compound Breakdown %
DMDM Hydantoin 71%
Methyl chloroisothiazolinone 0.04%
Methylisothiazolinone 0.01%
QS water 28.95%

Features & Benefits

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Benefit Claims
Key Attributes
  • Stable, synergistic, patented blend
  • Colorless liquid preservative
  • Low isothiazolinone levels in end products   (< 1 ppm)
  • Ultra-low free formaldehyde (< 0.09 %)
  • Safe toxicology profile
  • Broad spectrum efficacy
  • Neutral pH
  • Effective against formaldehyde and isothiazolinone resistant organisms
  • Color stability
  • Ease of handling
  • Compatible and soluble in virtually all raw materials
  • Aqueous, non-freezing blend

Applications & Uses

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Use Level
0.05 – 0.2 %
Application pH Range
3–9
Applications
  • Anhydrous
  • Body wash
  • Conditioner
  • Cream
  • Deo/Anti-Perspirant
  • Eye creams/gels
  • Eye shadow
  • Face lotion
  • Face wipes
  • Facial cream
  • Foundation
  • Hair gel
  • Hand soap (non anti-bac)
  • Lotion
  • Makeup remover
  • Mascara
  • Oil in Water
  • Powder
  • Shampoo
  • Sun Care
  • Toner
  • Water in Oil
Formulation Recommendations
  • Readily soluble in aqueous phase, as well as in polar organic solvents
  • Reducing agents, amines and strong nucleophiles will reduce activity of MCI/MI
  • When used with amines, pH should be below 6 before addition
  • Surfactants should be checked for residual bisulfite before addition
  • Should be added during the cool down phase of processing, at temperature of 50°C or below
  • pH: 3–9

Properties

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Physical Form
Physical Form
Liquid
Color
Colorless
Odor
Mild

Regulatory & Compliance

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Global Regulatory

Europe

  • Not permitted for leave-on products. Maximum use level of 0.0015 % CMI/MI for rinse-off applications

Japan

  • Max use level of 0.3 % DMDMH and 0.01 % CMI/MI for rinse-off
  • Not permitted for leave-on due to CMI/MI

US

  • Max use level of 0.6 % DMDMH and 0.00075 % CMI/MI for leave-on
  • Max use level of 0.6 % DMDMH and 0.0015 % CMI/MI for rinse-off

Technical Details & Test Data

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Efficacy

Studies were run using different concentrations of Lonzaserve® PC in various formulations to see efficacy against various bacteria, yeast and fungi. All samples were inoculated at the beginning of the study, sampled at 7, 14, 21 and 28 days.

Anionic Protein Shampoo

pH: 7

Ingredient %W/W
Sterile DI Water 36.0 %
Sodium Lauryl Ether Sulfate 35.0%
Triethanolamine Lauryl Sulfate 25.0%
Coco Diethanolamine 3.0%
Anhydrous Protein 1.0%
Total 100.00%
Test Results

Percent of Lonzaserve® PC required to achieve < 10 cfu/g of mixed bacteria in anionic shampoo

Lonza Lonzaserve PC Test Results - 1

Percent of Lonzaserve® PC required to achieve < 10 cfu/g of mixed fungi in anionic shampoo

Lonza Lonzaserve PC Test Results - 2

Non-Ionic Cream

pH: 6

Ingredient %W/W
Aldosperse® 4.0%
Aldo® MSC 6.0%
Cetearyl Alcohol 1.5%
Lonzest® 143-S 8.0%
Glycon G 5.0%
Water Q.S.
Total 100.00%
Test Results

Percent of Lonzaserve® PC required to achieve < 10 cfu/g of mixed bacteria in a nonionic cream

Lonza Lonzaserve PC Test Results - 1

Percent of Lonzaserve® PC required to achieve < 10 cfu/g of mixed fungi in a nonionic cream

Lonza Lonzaserve PC Test Results - 2

Packaging & Availability

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Regional Availability

Documents (3)

Document Name
Type
Products
Technical Data Sheet
Lonzaserve® PC
Technical Data Sheet
Products: Lonzaserve® PC
Brochure
Cosmocil® CQ, Geogard® 111A, Geogard® 111S, Geogard® 221, Geogard® ECT, Geogard® LSA, Geogard Ultra®, Glycacil® 2000, Glycacil® L, Glydant®, Glydant® 2000, Glydant® LTD, Glydant Plus® Liquid, Isocil® PC, Lonzagard® Benzethonium Chloride, Lonzaserve® PC, Mikrokill® COS, Spectradyne™, Glydant® Plus
Brochure
Products: Cosmocil® CQ, Geogard® 111A, Geogard® 111S, Geogard® 221, Geogard® ECT, Geogard® LSA, Geogard Ultra®, Glycacil® 2000, Glycacil® L, Glydant®, Glydant® 2000, Glydant® LTD, Glydant Plus® Liquid, Isocil® PC, Lonzagard® Benzethonium Chloride, Lonzaserve® PC, Mikrokill® COS, Spectradyne™, Glydant® Plus
Brochure
Aldo® MSD Kfg, Aldo® PGHMS Kfg, Amphoterge® K-2, Amphoterge® K-J-2-50%, Amphoterge® W, Amphoterge® W-2, Biocell™ SOD, Carnipure® Crystalline, Carnipure® Tartrate, Carsoquat® 450i, Carsoquat® CT-429, Carsoquat® SDQ-25, Carsoquat® SDQ-85, Cosmocil® CQ, Geogard® 111A, Geogard® 111S, Geogard® 221, Geogard® ECT, Geogard® LSA, Geogard Ultra®, Glycacil® 2000, Glycacil® L, Glydant®, Glydant® 2000, Glydant® LTD, Glydant Plus® Liquid, Isocil® PC, LaraCare® A200, Lonza Gel Base BSM5, Lonza Marula Oil, Lonza Niacinamide USP PC, Lonzagard® Benzethonium Chloride, Lonzaserve® PC, Lonzest® GDL, Lonzest® GMO, Lonzest® GMS-C, Lonzest® GMS-D, Lonzest® MSA, Lonzest® SML, Lonzest® SMO, Lonzest® SOC, Lonzest® STO, Metabiotics® Resveratrol ECT GEO, Mikrokill® COS, NAB® Butterbur Extract, NAB® Rhodiola Extract, Natrulon® H-10, Natrulon® H-6, Pegosperse® 100-S, Pegosperse® 1500 MS, Pegosperse® 400 DL, Pegosperse® 400 DS VEG, Pegosperse® 400 ML, Pegosperse® 50 DS, Pegosperse® 50 MS, SeaPure® Agarose, Solu-Mar® Elastin SD, Spectradyne™, ViscUp® 160, Vitazyme® A Plus, Zinc Omadine® 48% FPS Cosm Grade, Ethosperse® LA-23, Ethosperse® LA-4, Glycomul® S KFG, Glycomul® TS KFG, Glycosperse® L-20 KFG, Glycosperse® O-20 KFG, Glycosperse® S-20 KFG, Glycosperse® TS-20 KFG, Metabiotics® Resveratrol, ScreenLight® Block, Pegosperse® 400 DS Special, SYNETH™ O3 K RSPO MB, SYNETH™ S7 K RSPO MB Pastille, SYNETH™ S8 K RSPO MB Pastille, SYNETH™ S10 K RSPO MB Pastille, SYNETH™ P11 K RSPO MB Pastille, SYNETH™ O13 K RSPO MB, SYNETH™ C15 K RSPO MB, SYNETH™ L15 K RSPO MB, XPressEV™, H₂OBioEV®, Modifect® EV, PO.Fresh®, Glydant Plus®
Brochure
Products: Aldo® MSD Kfg, Aldo® PGHMS Kfg, Amphoterge® K-2, Amphoterge® K-J-2-50%, Amphoterge® W, Amphoterge® W-2, Biocell™ SOD, Carnipure® Crystalline, Carnipure® Tartrate, Carsoquat® 450i, Carsoquat® CT-429, Carsoquat® SDQ-25, Carsoquat® SDQ-85, Cosmocil® CQ, Geogard® 111A, Geogard® 111S, Geogard® 221, Geogard® ECT, Geogard® LSA, Geogard Ultra®, Glycacil® 2000, Glycacil® L, Glydant®, Glydant® 2000, Glydant® LTD, Glydant Plus® Liquid, Isocil® PC, LaraCare® A200, Lonza Gel Base BSM5, Lonza Marula Oil, Lonza Niacinamide USP PC, Lonzagard® Benzethonium Chloride, Lonzaserve® PC, Lonzest® GDL, Lonzest® GMO, Lonzest® GMS-C, Lonzest® GMS-D, Lonzest® MSA, Lonzest® SML, Lonzest® SMO, Lonzest® SOC, Lonzest® STO, Metabiotics® Resveratrol ECT GEO, Mikrokill® COS, NAB® Butterbur Extract, NAB® Rhodiola Extract, Natrulon® H-10, Natrulon® H-6, Pegosperse® 100-S, Pegosperse® 1500 MS, Pegosperse® 400 DL, Pegosperse® 400 DS VEG, Pegosperse® 400 ML, Pegosperse® 50 DS, Pegosperse® 50 MS, SeaPure® Agarose, Solu-Mar® Elastin SD, Spectradyne™, ViscUp® 160, Vitazyme® A Plus, Zinc Omadine® 48% FPS Cosm Grade, Ethosperse® LA-23, Ethosperse® LA-4, Glycomul® S KFG, Glycomul® TS KFG, Glycosperse® L-20 KFG, Glycosperse® O-20 KFG, Glycosperse® S-20 KFG, Glycosperse® TS-20 KFG, Metabiotics® Resveratrol, ScreenLight® Block, Pegosperse® 400 DS Special, SYNETH™ O3 K RSPO MB, SYNETH™ S7 K RSPO MB Pastille, SYNETH™ S8 K RSPO MB Pastille, SYNETH™ S10 K RSPO MB Pastille, SYNETH™ P11 K RSPO MB Pastille, SYNETH™ O13 K RSPO MB, SYNETH™ C15 K RSPO MB, SYNETH™ L15 K RSPO MB, XPressEV™, H₂OBioEV®, Modifect® EV, PO.Fresh®, Glydant Plus®