Knowde Enhanced TDS
Identification & Functionality
- INCI Name
- Ingredient Origin
- Cosmetic Ingredients Functions
- CAS No.
- 9004-53-9
- EC No.
- 232-675-4
- Technologies
- Product Families
Features & Benefits
- Benefit Claims
- Labeling Claims
- Product Benefits
- Reduces pro-inflammatory marker IL-1α
- Reduces TEWL induced by chemical and mechanical aggression
- Significantly reduces redness after only 10 minutes
- Helps to sooth skin and scalp
- Preserves the diversity of the skin microflora
Applications & Uses
- Markets
- Treatment Product Applications
- Suggested Use Level
- 2 - 5%
Properties
- Soluble in
- Water
Regulatory & Compliance
- Certifications & Compliance
Technical Details & Test Data
- Efficacy Studies
Step 1: Significantly Reduces Pro-inflammatory Marker IL-1α
Evaluation of the soothing effect of Beauté by Roquette® DE 006 at 2% and 5% on keratinocytes (2D): First, a positive control with 0.001% (sub cytotoxic concentration) of SLS (Sodium Lauryl Sulfate) is applied for 6 h. Then, the product is applied 20 hours and we measured the IL-1α expression after 26 hours.
*Significant difference versus SLS 0.001% (ANOVA then multiple comparison Dunnett, p value<0.05)Step 2: Significantly Decreases Trans Epidermal Water Loss
Beauté by Roquette® DE 006 at 5% (in vivo, 60 volunteers, Male with sensitive skin, SLS patches test):
- Protects the skin from TEWL right after application due to a film forming effect & impact on IL-1α.
- Significantly reduces TEWL versus placebo after 7 days.
- Helps to maintain an efficient skin barrier function allowing to retain skin hydration.
Step 3: Significantly Decreases Skin Redness
Beauté by Roquette® DE 006 at 5% (in vivo, 60 volunteers, Male with sensitive skin, SLS patches test):
- Significantly reduces redness vs α-bisabolol after 10 minutes.
- Significantly reduces redness after 30 minutes and 7 days vs placebo.
* Significant versus α-Bisabolol p-value < 0.1
** Significant versus placebo p-value < 0.1