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Salizole

1 of 1 products in this brand
Salizole is topical antifungal agent commonly used in the treatment of human fungal skin infections such as dandruff and eczema. Salizole has high in vitro and in vivo efficacy against Pityrosporum ovale that appears to play an important role in the pathogenesis of dandruff. It's chemical structure and properties are similar to Ketoconazole and Miconazole. It is usually accompanied by other active ingredients such as Zinc Pyrithione or Triclosan and is commonly found as an active ingredient in OTC anti-dandruff and anti-fungal products, including shampoos, lotions and conditioners.

INCI Name: Climbazole

Functions: Anti-Dandruff Agent, Anti-Microbial Agent, Fungistatic Agent

Certifications & Compliance: United States Pharmacopeia (USP)

Benefit Claims: Anti-Acne, Anti-Dandruff, Anti-Fungal, Conditioning

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Knowde Enhanced TDS

Identification & Functionality

INCI Name

Climbazole

Cosmetic Ingredients Functions

Anti-Dandruff Agent,

Anti-Microbial Agent,

Fungistatic Agent

CAS No.
38083-17-9
EC No.
253-775-4
Technologies

Cosmetic Ingredients

Product Families

Cosmetic Ingredients — Cosmetic Actives

Hair Actives,

Other OTC Actives

Cosmetic Ingredients — Functionals

Antioxidants & Preservatives

Features & Benefits

Benefit Claims

Anti-Acne,

Anti-Dandruff,

Anti-Fungal,

Conditioning

Applications & Uses

Markets

Personal Care

Applications

Personal Care — Beauty & Care

Hair Care,

Skin Care,

Treatment Products

Application Format

Creams,

Lotions,

Ointments,

Rinse Off

Hair Care Applications

Anti-Dandruff Products,

Hair Conditioner,

Hair Treatment & Repair,

Shampoos & Rinses

Treatment Product Applications

Anti-Dandruff Products

Use Level
max. 0.5%
Formulation Guidelines
  • Salizole is used in pharma based formulations and also in cosmetic formulations in combination with Piroctone Olamine.
  • This is a better antidandruff agent than zinc pyrithione. However, there are reports which suggest that it could cause irritation round the eye counter if used alone hence it is used in combination with Piroctone Olamine.
  • Can be added in the formulation up to 70°C without affecting the activity.

Regulatory & Compliance

Certifications & Compliance

United States Pharmacopeia (USP)

Regulatory Compliance
  • Climbazole is currently regulated in the Cosmetics Directive as a preservative in Annex VI, with a maximum authorized concentration of 0.5%.
  • According to the submitted dossier, Climbazole is used as an anti-dandruff active agent in hair cosmetic preparations up to a maximum concentration of 2.0% in rinse-off products or up to a maximum concentration of 0.5% in leave-on products. In addition, it is used in leave-on face creams up to a maximum concentration of 0.5%.