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LIPOXOL 300 MED

LIPOXOL 300 MED

A clear liquid polymer soluble in water, LIPOXOL 300 MED is produced by the addition of ethylene oxide to ethylene glycol. For documents specific to a region, please contact Sasol using the 'Request Document' button.
Product Resources

Knowde Enhanced TDS

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Identification & Functionality

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Features & Benefits

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Applications & Uses

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Recommended Uses & Known Applications
  • LIPOXOL MED grades are widely used excipients in a variety of pharmaceutical preparations. The liquid LIPOXOL MED grades are used as solvent, solubilizer and viscosity regulator in liquid pharmaceutical formulations. Mixtures of liquid and solid LIPOXOL MED grades are used as ointment bases. Solid LIPOXOL MED grades are used as suppository bases and act as binders and plasticizers for tablets.
  • The liquid LIPOXOL MED grades are readily soluble in water and miscible in all portions with other grades. With increasing molecular weight the solubility in water is slightly lowered. 
  • The LIPOXOL MED grades are (according to their molecular weight) soluble in polar organic solvents like alcohols, benzene, glycerine glycol and chloroform. No or slight solubility is given in aliphatic hydrocarbons, ethers and fats. LIPOXOL MED grades can be used to enhance the aqueous solubility or dissolution characteristics of poorly soluble compounds.
  • Due to their hygroscopicity the LIPOXOL MED grades are used as moisturizers which provide soft and readily dispersible ointment bases causing a liquid flow opposed to the resorption. On skin they show a cleansing and drying effect. Therefore LIPOXOL MED containing ointments can be used to treat wet and inflamed wounds.
  • Liquid LIPOXOL MED grades are used as water miscible solvents dedicated for dissolution of actives in soft gelatine capsules. Aqueous solutions of LIPOXOL MED grades can be either used as suspending agents or to adjust the viscosity and consistency of pharmaceutical products. When used in combination with emulsifiers LIPOXOL MED grades can act as emulsion stabilizers.

Properties

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Physical Form
Odor
Mild
Appearance
Clear
Miscible In
Water
Typical Properties
ValueUnitsTest Method / Conditions
Color Number (APHA, 25% in water)max. 15mg Pt/lDIN EN 1557
Color Number (25 % in water)min. 6BYPh. Eur.
Average molar mass285 - 315g/molCalc. from OH no
pH (5 % in demin. water)4.5 - 7.5-USP/NF
Dynamic Viscosity at 20°C80 - 105mPa.sPh. Eur.
Kinematic Viscosity at 98.9°C5.4 - 6.4mm2/sUSP/NF
Heavy Metals as Pbmax. 5mg/kgUSP/NF
Ethylene and Diethylene Glycol Contentmax. 2500mg/kgAB 039 010 (Internal Method)
Ethylene Glycol Contentmax. 620mg/kgAB 039 010 (Internal Method)
Acid/alkaline React. Substancesmax. 0.1ml 0.1 M NaOHPh. Eur.
Red. substancesmin. 3RPh. Eur.
Sulfate Ash Contentmax. 0.1%-
1,4-Dioxane Contentmax. 1mg/kgPh. Eur.
Surface Tension (at 20°C)48.0mN/m-
Water Contentmax. 1.0%-
Ethylene Oxide Contentmax. 1mg/kgPh. Eur.
Acid Numbermax. 0.2mg KOH/gEN ISO 2114
Flash Pointapprox. 220°CISO 2592
Ignition Temperatureapprox. 370°CDIN 51794
Freezing Point-20 to -10°C-
Density at 20°Capprox. 1.12g/cm3-
Formaldehyde Contentmax. 30mg/kgPh. Eur.
Assay Content95 - 105%USP/NF
Hydroxyl Number356 - 394mg KOH/gDIN EN 13296

Regulatory & Compliance

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Technical Details & Test Data

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Statements and Confirmations

California Prop. 65 list

LIPOXOL MED grades contains the following chemicals found on the California Proposition 65 list of chemicals published by the Governor of California:

  • 1,4-Dioxane (max. 1 mg/kg)  
  • Ethylene oxide (max. 1 mg/kg)
  • Formaldehyde (max. 30 mg/kg)
  • Ethylene glycol (max. 620 mg/kg)

Cosmetic

Assuming the use of the raw materials and manufacturing process currently employed the LIPOXOL MED grades fulfils the requirements regarding the annexes of the regulation No. (EC) 1223/2009 with the exception of very small amounts of free Ethylene oxide (≤ 1 ppm), Formaldehyde (≤ 30 ppm) and 1,4-Dioxane (≤ 1 ppm) which are characteristic for this type of product.

With regard to the Diethylene glycol content which is limited to max. 0.1% for the ready to use cosmetic product (Annex III) please consider the Diethylene glycol content of the relevant LIPOXOL MED type (exception for LIPOXOL 300 MED).

CMR

We hereby confirm that, to the best of our present knowledge, assuming the use of the raw materials and manufacturing process currently employed, LIPOXOL MED does not contain any CMR-substances classified as CMR category 1A, 1B an 2 in accordance with regulation No. (EC) 1272/2008 and its adaptations, with the exception of very small amounts of free Ethylene oxide (≤ 1 ppm), Formaldehyde (≤ 30 ppm) and 1,4-Dioxane (≤ 1 ppm) which are characteristic for this type of product.

Halal

  • LIPOXOL MED grades are not produced under muslimic supervision
  • Intermediates, starting material and LIPOXOL MED grades are of non-animal origin
  • LIPOXOL MED grades are made by a process in which only auxiliaries of non-animal origin have been used
  • Processing equipment is only used for products of non-animal origin
  • We permit in case of request a muslimic inspection of the production plant

LIPOXOL MED grades are free of Lactose, Latex, Gluten, Yeast, Maize, Wheat, Pork, Starch, Dyes and Nuts

Microbiological purity

  • The parameter given in chapter 5.1.4 (Microbiological quality of non-sterile pharmaceutical preparations and substances for pharmaceutical use) are regularly checked.
  • The determination of TAMC (total aerobic microbial count) and TYMC (total yeasts and moulds count) is done according to Ph. Eur. 2.6.12. (Microbiological examination of non-sterile products: microbial enumeration tests) and the limits of
  • TAMC ≤ 1000 cfu/g
  • TYMC ≤ 100 cfu/g  can be confirmed.

Retest date

  • LIPOXOL MED grades with an average molecular weight of < 1000 g/mol: 2 years starting with the date of production
  • LIPOXOL MED grades with an average molecular weight of ≥ 1000 g/mol: 3 years starting with the date of production

SVHC substances

Assuming the use of the raw materials and manufacturing process currently employed the LIPOXOL MED grades do not contain any substances from the SVHC list (candidate list).

WADA list

Assuming the use of the raw materials and manufacturing process currently employed the LIPOXOL MED grades do not contain any substances from the WADA list (world anti-doping association).

GMP Status

The following products are produced and filled according to Good Manufacturing Practice (GMP) standard relating to Article 47 Directive 2001/83/EC:

  • LIPOXOL 300 MED up to 8000 MED in tank cars

Packaging & Availability

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Packaging Information

Road tankers (melt), steel drums of 220 kg.

Storage & Handling

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Storage And Handling

Precautions for safe handling 

Advice on safe handling

  • No special technical protective measures required.

Advice on protection against fire and explosion

  • Normal measures for preventive fire protection.

Fire-fighting class

  • B: Fires involving liquids or liquid containing substances. Also includes substances which become liquid at elevated temperatures.

Conditions for safe storage, including any incompatibilities

Storage class (TRGS 510)

  • 10-13: German Storage Class 10 to 13

Other data

  • Keep in a dry place.

Container Material

  • Suitable Materials: Steel

Most Viewed Documents

View All 6 Documents

Document Name
Type
Products
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Raw Materials For Cosmetics
Brochure
TRIDAC ISO-3, TRIDAC ISO-8, LIPOXOL 4000 MED, LIPOXOL 6000 MED, ALCHEM 123, COSMACOL ECI, COSMACOL ELI, COSMACOL EMI, MARLINAT 242/70 C, ALFOL 1216 CO, ALFOL 1618 CG, ALFOL 1618GC, ALFOL 8, COSMACOL N II-9, ISOFOL 18 T, MARLINAT 242/70 B, MARLINAT 242/90 MC, MARLOSOL PK 9040, NACOL 16-98, NACOL 18-98, NAFOL 1618 H, NAFOL 1618, EMULDAC AS-18, SAFOL 23E2 Ethoxylate, ISALCHEM 145, LIAL 125, MARLOWET CG, SAFOL 23E6.5 Ethoxylate, Sasol AES 270N-II, NOVEL 1618-80 Ethoxylate, Sasol AAES 370ZN, Sasol AEO4-24Z, MULTISO 13/89, COSMACOL AES 70-2-24, COSMACOL ECL, ALFOL 1618, CERALUTION ES RSPO-MB, CERALUTION H RSPO-MB, COSMACOL OE, LIPOXOL 1000 MED, LIPOXOL 1500 MED, LIPOXOL 400 MED, LIPOXOL 600 MED, LIPOXOL 300 MED, ISALCHEM 125, ISOFOL 24, ISOFOL 32, LIAL 123, LIAL 145, LIALCHEM 25/75, LIALET 111-5,5, LIPOXOL 3350 MED powder, LIPOXOL 8000 MED powder, MARLINAT 242/28, MARLIPAL 1618/11, MARLIPAL 24/100, MARLIPAL 24/20, MARLIPAL 24/30, MARLIPAL 24/40, MARLIPAL 24/50, MARLIPAL 24/60, MARLIPAL 24/70, MARLIPAL 24/79, MARLIPAL 24/99, MARLIPAL O 13/100, MARLIPAL O 13/109, MARLIPAL O 13/120, MARLIPAL O 13/129, MARLOSOL TA 30, MARLIPAL O 13/30, MARLIPAL O 13/40, MARLIPAL O 13/50, MARLIPAL O 13/60, MARLIPAL O 13/69, MARLIPAL O 13/70, MARLIPAL O 13/79, MARLIPAL O 13/80, MARLIPAL O 13/89, MARLIPAL O 13/90, MARLIPAL O 13/99, MARLOWET 1072, Sasol Monoethanolamine, pure cosmetic, NACOL 20-95, NOVEL 1012-6 Ethoxylate, MARLOSOL TA 60, PARAFOL 22-95, SAFOL 23E3 Ethoxylate, SAFOL 23E5 Ethoxylate, SAFOL 23E7 Ethoxylate, SAFOL 23E9 Ethoxylate, ALFONIC 1216CO-3 Ethoxylate, SAFOL 23A70, NOVEL 1216CO-7 Ethoxylate, SAFOL 23E2S, NOVEL 16-20 Ethoxylate, NOVEL 18-20 Ethoxylate, NOVEL 23E6.5 Ethoxylate, NOVEL 23E9 Ethoxylate, Sasol AEO7-24Z, Sasol AEO5-24Z, NOVEL TDA-100 Ethoxylate, NOVEL TDA-12 Ethoxylate, NOVEL 810-4.5 Ethoxylate, NOVEL TDA-150 Ethoxylate, NOVEL TDA-3 Ethoxylate, NOVEL TDA-5 Ethoxylate, NOVEL TDA-6 Ethoxylate, MARLOSOL TA 90, NOVEL TDA-8 Ethoxylate, MULTISO 13/70, MULTISO 13/50, MULTISO 13/90, NOVEL TDA-9 Ethoxylate, MULTISO 13/120, MARLOSOL TA 50, NOVEL 22-25 Ethoxylate, MARLOSOL TA 80, NOVEL 23E30 Ethoxylate, SAFOL 23E4 Ethoxylate, NOVEL 1412-3 Ethoxylate, NOVEL 1412-7 Ethoxylate, NOVEL 23E3 Ethoxylate, NOVEL 23E7 Ethoxylate, NOVEL 1618CG-25 (PSTLLE), GALENOL 1618 AE, NOVEL TDA-30 Ethoxylate, ALCHEM 145, TRIDAC ISO-12, TRIDAC ISO-40, TRIDAC ISO-5, TRIDAC ISO-6, MULTISO 13/100, ALFOL 12, LIALET 111-3, LIALET 111-7, LORODAC 4-24, ALFOL 10, ALFOL 16, ALFOL 14, ALFOL 6, NOVEL 1216CO-2 ETHOXYLATE, NOVEL TDA-7 ETHOXYLATE, NAFOL 1618 S, ISOFOL 16, ISOFOL 20 Native, NOVEL 1412-9 ETHOXYLATE, ISOCARB 12, LIALET 111-8, EMULDAC AS-80, ALFOL 18, COSMACOL AES 27-2-24, ISOFOL 18 E, MARLINAT 242/28 UK, ALFOL 1618 E Alcohol, Sasol AAES 370N-II, EMULDAC AS-25, NAFOL 1822 B, NAFOL 1822 C, MARLIPAL SU, MARLOSOL ST 9150 P, NACOL 16-95, NAFOL 2022 E, NAFOL 2022, ALFONIC 1216CO-2 ETHOXYLATE, MARLIPAL O13 Alcohol, NOVEL 12-23 ETHOXYLATE, NOVEL 1412-2 ETHOXYLATE, NOVEL 16-3 ETHOXYLATE, NOVEL 23E2 ETHOXYLATE, NOVEL TDA-4 ETHOXYLATE, NOVEL TDA-40 ETHOXYLATE, GALENOL 2100, GALENOL 2800, GALENOL 2880, MARLOSOL TA 70, MULTISO 13/30, MULTISO 13/60, MULTISO 13/80, Sasol ALS-70, ISOFOL 28, NACOL 14-95, PARAFOL 12 RSPO-MB, PARAFOL 14 RSPO-MB
Brochure
Products: TRIDAC ISO-3, TRIDAC ISO-8, LIPOXOL 4000 MED, LIPOXOL 6000 MED, ALCHEM 123, COSMACOL ECI, COSMACOL ELI, COSMACOL EMI, MARLINAT 242/70 C, ALFOL 1216 CO, ALFOL 1618 CG, ALFOL 1618GC, ALFOL 8, COSMACOL N II-9, ISOFOL 18 T, MARLINAT 242/70 B, MARLINAT 242/90 MC, MARLOSOL PK 9040, NACOL 16-98, NACOL 18-98, NAFOL 1618 H, NAFOL 1618, EMULDAC AS-18, SAFOL 23E2 Ethoxylate, ISALCHEM 145, LIAL 125, MARLOWET CG, SAFOL 23E6.5 Ethoxylate, Sasol AES 270N-II, NOVEL 1618-80 Ethoxylate, Sasol AAES 370ZN, Sasol AEO4-24Z, MULTISO 13/89, COSMACOL AES 70-2-24, COSMACOL ECL, ALFOL 1618, CERALUTION ES RSPO-MB, CERALUTION H RSPO-MB, COSMACOL OE, LIPOXOL 1000 MED, LIPOXOL 1500 MED, LIPOXOL 400 MED, LIPOXOL 600 MED, LIPOXOL 300 MED, ISALCHEM 125, ISOFOL 24, ISOFOL 32, LIAL 123, LIAL 145, LIALCHEM 25/75, LIALET 111-5,5, LIPOXOL 3350 MED powder, LIPOXOL 8000 MED powder, MARLINAT 242/28, MARLIPAL 1618/11, MARLIPAL 24/100, MARLIPAL 24/20, MARLIPAL 24/30, MARLIPAL 24/40, MARLIPAL 24/50, MARLIPAL 24/60, MARLIPAL 24/70, MARLIPAL 24/79, MARLIPAL 24/99, MARLIPAL O 13/100, MARLIPAL O 13/109, MARLIPAL O 13/120, MARLIPAL O 13/129, MARLOSOL TA 30, MARLIPAL O 13/30, MARLIPAL O 13/40, MARLIPAL O 13/50, MARLIPAL O 13/60, MARLIPAL O 13/69, MARLIPAL O 13/70, MARLIPAL O 13/79, MARLIPAL O 13/80, MARLIPAL O 13/89, MARLIPAL O 13/90, MARLIPAL O 13/99, MARLOWET 1072, Sasol Monoethanolamine, pure cosmetic, NACOL 20-95, NOVEL 1012-6 Ethoxylate, MARLOSOL TA 60, PARAFOL 22-95, SAFOL 23E3 Ethoxylate, SAFOL 23E5 Ethoxylate, SAFOL 23E7 Ethoxylate, SAFOL 23E9 Ethoxylate, ALFONIC 1216CO-3 Ethoxylate, SAFOL 23A70, NOVEL 1216CO-7 Ethoxylate, SAFOL 23E2S, NOVEL 16-20 Ethoxylate, NOVEL 18-20 Ethoxylate, NOVEL 23E6.5 Ethoxylate, NOVEL 23E9 Ethoxylate, Sasol AEO7-24Z, Sasol AEO5-24Z, NOVEL TDA-100 Ethoxylate, NOVEL TDA-12 Ethoxylate, NOVEL 810-4.5 Ethoxylate, NOVEL TDA-150 Ethoxylate, NOVEL TDA-3 Ethoxylate, NOVEL TDA-5 Ethoxylate, NOVEL TDA-6 Ethoxylate, MARLOSOL TA 90, NOVEL TDA-8 Ethoxylate, MULTISO 13/70, MULTISO 13/50, MULTISO 13/90, NOVEL TDA-9 Ethoxylate, MULTISO 13/120, MARLOSOL TA 50, NOVEL 22-25 Ethoxylate, MARLOSOL TA 80, NOVEL 23E30 Ethoxylate, SAFOL 23E4 Ethoxylate, NOVEL 1412-3 Ethoxylate, NOVEL 1412-7 Ethoxylate, NOVEL 23E3 Ethoxylate, NOVEL 23E7 Ethoxylate, NOVEL 1618CG-25 (PSTLLE), GALENOL 1618 AE, NOVEL TDA-30 Ethoxylate, ALCHEM 145, TRIDAC ISO-12, TRIDAC ISO-40, TRIDAC ISO-5, TRIDAC ISO-6, MULTISO 13/100, ALFOL 12, LIALET 111-3, LIALET 111-7, LORODAC 4-24, ALFOL 10, ALFOL 16, ALFOL 14, ALFOL 6, NOVEL 1216CO-2 ETHOXYLATE, NOVEL TDA-7 ETHOXYLATE, NAFOL 1618 S, ISOFOL 16, ISOFOL 20 Native, NOVEL 1412-9 ETHOXYLATE, ISOCARB 12, LIALET 111-8, EMULDAC AS-80, ALFOL 18, COSMACOL AES 27-2-24, ISOFOL 18 E, MARLINAT 242/28 UK, ALFOL 1618 E Alcohol, Sasol AAES 370N-II, EMULDAC AS-25, NAFOL 1822 B, NAFOL 1822 C, MARLIPAL SU, MARLOSOL ST 9150 P, NACOL 16-95, NAFOL 2022 E, NAFOL 2022, ALFONIC 1216CO-2 ETHOXYLATE, MARLIPAL O13 Alcohol, NOVEL 12-23 ETHOXYLATE, NOVEL 1412-2 ETHOXYLATE, NOVEL 16-3 ETHOXYLATE, NOVEL 23E2 ETHOXYLATE, NOVEL TDA-4 ETHOXYLATE, NOVEL TDA-40 ETHOXYLATE, GALENOL 2100, GALENOL 2800, GALENOL 2880, MARLOSOL TA 70, MULTISO 13/30, MULTISO 13/60, MULTISO 13/80, Sasol ALS-70, ISOFOL 28, NACOL 14-95, PARAFOL 12 RSPO-MB, PARAFOL 14 RSPO-MB
LIPOXOL MED Grades Technical Data Sheet
Technical Data Sheet
LIPOXOL 4000 MED powder, LIPOXOL 3350 MED flakes, LIPOXOL 4000 MED flakes, LIPOXOL 4000 MED SP, LIPOXOL 6000 MED powder, LIPOXOL 8000 MED flakes, LIPOXOL 1000 MED, LIPOXOL 1500 MED, LIPOXOL 400 MED, LIPOXOL 600 MED, LIPOXOL 300 MED, LIPOXOL 3350 MED powder, LIPOXOL 6000 MED flakes, LIPOXOL 8000 MED powder, LIPOXOL 3000 flakes, LIPOXOL 3350 MED SP
Technical Data Sheet
Products: LIPOXOL 4000 MED powder, LIPOXOL 3350 MED flakes, LIPOXOL 4000 MED flakes, LIPOXOL 4000 MED SP, LIPOXOL 6000 MED powder, LIPOXOL 8000 MED flakes, LIPOXOL 1000 MED, LIPOXOL 1500 MED, LIPOXOL 400 MED, LIPOXOL 600 MED, LIPOXOL 300 MED, LIPOXOL 3350 MED powder, LIPOXOL 6000 MED flakes, LIPOXOL 8000 MED powder, LIPOXOL 3000 flakes, LIPOXOL 3350 MED SP
LIPOXOL 300 MED Safety Data Sheet EN-DE
Safety Data Sheet
LIPOXOL 300 MED
Safety Data Sheet
Products: LIPOXOL 300 MED
LIPOXOL 300 MED Safety Data Sheet EN-IE
Safety Data Sheet
LIPOXOL 300 MED
Safety Data Sheet
Products: LIPOXOL 300 MED
LIPOXOL 300 MED Safety Data Sheet EN-US
Safety Data Sheet
LIPOXOL 300 MED
Safety Data Sheet
Products: LIPOXOL 300 MED
LIPOXOL 300 MED Safety Data Sheet EN-GB
Safety Data Sheet
LIPOXOL 300 MED
Safety Data Sheet
Products: LIPOXOL 300 MED
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