Heterosides

Heterosides is a highly purified water-soluble extract of Centella asiatica for skin barrier function improvement. This product provides stratum corneum formation enhancement, tight junctions reinforcement, differentiation normalization and activation of the deeper layers of the epidermis. Its anti-wrinkle effect has been recently demonstrated on the crow’s feet. Significant TEWL reduction on volunteers with a dry skin has been also observed. This is a titrated blend of the glycosylated triterpens Asiaticoside and Madecassoside. This is an active ingredient for use in intense skin care applications for dry and dehydrated skin, as well as mature skin. It comes as a crystalline powder.

INCI Name: Centella Asiatica Leaf Extract

Functions: Anti-Aging Agent, Conditioner, Skin Barrier Protectant

Ingredient Origin: Natural Origin, Plant Origin

Labeling Claims: Clean at Sephora, Credo Clean Standard, Preservative-free, Ulta Beauty's Conscious Beauty

Certifications & Compliance: Quasi-Drug Additive

Benefit Claims: Anti-Aging, Skin Barrier, Wrinkle Prevention

Knowde Enhanced TDS

Identification & Functionality

CAS No.
84696-21-9
EC No.
283-640-5

Features & Benefits

Product Benefits
  • TEWL reduction: -8% vs Placebo (D28)
  • Smoothing effect:-36% vs Placebo(D28)
  • Anti-wrinkle effect: -19% vs Placebo(D56)

Applications & Uses

Color Cosmetic Applications
Hair Care Applications
Use Level
0.2-0.5%
Mode of Action
  • Reinforce the "mortar" (Ceramides-2: +44%)
  • Strenghten the "brick" envelop (Involucrin, Loricrin, Filaggrin)
  • Boost cell cohesion (tight junctions)
  • Moisturize (AQP3: +29%) & soothe (PGE-2, IL-8, IL-1α)
  • It prevents dehydration by reactivating all the natural mechanisms that restructure and pamper the skin barrier
  • It erases fine lines and wrinkles by enhancing water retention and dermis scaffold

Properties

Physical Form
Soluble in
Water
Typical Properties
ValueUnitsTest Method / Conditions
Active Contentmax. 70%

Regulatory & Compliance

Certifications & Compliance

Packaging & Availability

Country Availability
Regional Availability
  • Asia Pacific
  • Canada
  • Europe
  • North America
  • USA