SEPPIC INC Madecassoside

Identification & Functionality

Active Component

Madecassoside

Chemical Family

Silicates

Chemical Name

Siloxanes and Silicones, di-Me, reaction products with silica

INCI Name

Madecassoside

Ingredient Origin

Natural Origin,

Plant Origin

Cosmetic Ingredients Functions

Anti-Aging Agent,

Moisturizing Agent,

Soothing Agent

CAS No.

67762-90-7

EC No.

614-122-2

Technologies

Cosmetic Ingredients

Product Families

Cosmetic Ingredients — Cosmetic Actives

Skin Actives

Cosmetic Ingredients — Functionals

Conditioners & Emollients,

Sensory Modifiers

Cosmetic Ingredients — Vitamins, Extracts & Oils

Botanical Ingredients & Extracts

Features & Benefits

Benefit Claims

Anti-Aging,

Anti-Inflammatory,

Anti-Itching,

Anti-Peeling,

Antioxidant Properties,

Comforting,

Healing,

Moisturizing,

Redness Reduction,

Regenerating,

Repairing,

Skin Barrier,

Soothing

Labeling Claims

Clean at Sephora,

Preservative-free,

Ulta Beauty's Conscious Beauty

Applications & Uses

Markets

Personal Care

Applications

Personal Care — Beauty & Care

Bath & Shower,

Hair Care,

Skin Care,

Treatment Products

Application Format

Creams,

Gel,

Leave On,

Lotions,

Masks,

Ointments,

Rinse Off,

Serum

Hair Care Applications

Shampoos & Rinses

Skin Care Applications

Anti-Aging Products,

Face Cream,

Facial Mask,

Facial Moisturizer,

Hand Cream,

Moisturizers

Treatment Product Applications

Eczema Treatment

Use Level

0.2-0.5%

Mode of action

- ECM restructuration (Col I & Col III up to +49%)

- Respect of essential cell functions (TNF-α & NFkB activation; SKALP: -60%; free radicals: -70%)

- Normalization of keratinocytes hyperproliferation

- Soothing effect (MMP-1: -61%)

Properties

Physical Form

Powder,

Solid

Soluble in

Water

Typical Properties

	Value	Units	Test Method / Conditions
Purity	min. 95	%	—

Technical Details & Test Data

Efficacy Studies

- Itching sensation   -65%

- Erythema reduction   -25.7%

- Desquamation area reduction-  43.5%

- Efficacy on atopic / psioriasis-prone skin from D14:

- Soothing effect (Inflamm’Aging) / itching reduction up to 70%

- Anti-redness (erythema reduction up to -25,7%)

- Moisturizing effect (desquamation & PASI score reduction -43.5%)

- Smoothing effect (Roughness score)