Knowde Enhanced TDS
Identification & Functionality
- Carrier
- Ingredient Origin
- Cosmetic Ingredients Functions
- Technologies
- Origin
Combination of sulfurated amino acid with organic thio-derivative, both salified with lysine.
Features & Benefits
- Labeling Claims
- Key Attributes
- Sebum becomes less evident
- Indicated for oily skin and scalp
- Healthier skin and hair
- Ideal for dandruff shampoos and lotions
- High efficacy on the T-zone
- Available also version with preservative system
- Chromatographic identification and colorimetric determination is the method of analysis.
Applications & Uses
- Markets
- Hair Care Applications
- Nail Care Applications
- Skin Care Applications
- Treatment Product Applications
- Mode of Action
The sebum normalizing activity is associated to the presence of the sulfur bridge in Tiolisina®'s chemical structure. In fact, cysteine derivatives are reported in literature as sebum-controlling active ingredients while Thiazolidine is able to penetrate in the bulb and reduce the activity of lipase enzyme. The blend of its thiol groups has antibacterial properties. By retarding the regreasing, Tiolisina® allows to reduce the hair and scalp stress due to the excessive washing.
- Recommended Uses
- Anti-dandruff & sebum-normalizing products
- Both leave-on and rinse-off hair treatments
- Daily products for greasy skin
- Medical devices (e.g. Seborrheic dermatitis, acne treatments)
- Hair care
- Sebum control
- Usage Guidelines
Add to the aqueous phase. Temperatures must not exceed 40°C.
Properties
- Physical Form
- Odor
- Characteristic
- Typical Properties
- Microbiological Values
| Value | Units | Test Method / Conditions | |
| Nickel Content | max. 0.2 | ppm | — |
| Density (at 25°C ± 1) | 1.05 - 1.15 | — | — |
| Dry Residue (at 105°C ± 1) | 27 - 33 | — | — |
| pH | 6.50 - 7.50 | — | — |
| Refraction Index (at 20°C ± 1) | 1.378 - 1.398 | — | — |
| Value | Units | Test Method / Conditions | |
| Bacteria Count | max. 100 | CFU/ml | — |
| Yeasts And Molds Count | max. 10 | CFU/ml | — |
Regulatory & Compliance
- Certifications & Compliance
Technical Details & Test Data
- Efficacy Tests
In vitro:
- Anti-oxidant and protective activity against UVA
In vivo:
- Scalp: Sebometry and desquamation; self-assessment
- Face: Acne and irritation parameters (erythema, desquamation, itch)
- Product Solubility
- In water: more than 35%
- In ethanol 96°: soluble
- In glycol propylene soluble
- In H2O-ethanol mixtures: perfectly soluble in up to 45° alcohol ideal solubility limit without opalescence 40°alcohol
Safety & Health
- Toxicological Information
- Oral acute toxicity: ≥ 2000 mg/kg
- Skin irritation: not irritant
- Eye irritation: not irritant
- Skin sensitization: not sensitizing
Packaging & Availability
- Regional Availability
Storage & Handling
- Shelf Life
- 18 Months
- Preservative System
The product is preserved with:
Gramben II * ≤ 1 % *Propylene Glycol, Diazolidinyl Urea, Methylparaben, Propylparaben
- Storage and Handling
Keep product cool and away from light (temperature below 25°C). Store in an air-tight container. In some cases, a slight precipitate may form but this does not compromise the efficacy of the product