Products in Hair Care: Anti-Microbial Agent

Beauté by Roquette® SA 130 is a unique bio-succinic acid that provides a safe solution for acne-prone and oily skin in all types of cosmetic products. Benefits Natural alternative to salicylic acid Inhibits cutibacterium acnes ATCC 11827 strain Limitats pore clogging Reduces sebum level Reduces imperfections: comedones, pores size, shine and pimples Well tolerated by skin Good solubility Features Easy to use Obtained through a biotechnological process Co-developed tby DSM and Roquette

Beauté by Roquette® PO 500 is a new, patented microbiota-balancing active for oral health and skin care products. It also acts as a strong humectant and moisturizing agent. Benefits Reduces or neutralizes the growth of oral pathogen bacteria Prevents bad breath (halitosis), biofilm formation and dental caries Acts as a strong moisturizing agent to induce immediate skin or hair hydration Performs as an antimicrobial agent Imparts a pleasant, non-tacky feel on the skin Features Plant-based Extremely pure isosorbide solution High water and alcohol solubility High chemical stability even in alkaline conditions High thermal stability Non-cariogenic

Elestab® HP 100 soothes and moisturizes itchy, dry, flaky scalps while balancing dry and oily hair with long-lasting results, making it beneficial for hair and scalp care to promote a healthy scalp. It can also be formulated to support medicated and other shampoos.

MacDerma™ CSA can be obtained by the bark of willow trees. MacDerma™ CSA, or 2-hydroxyl-5-octanoyl benzoic acid is a lipophilized derivative of salicylic acid. The compound has corneolytic, anti-inflammatory, anti-microbial and anticomedonic activities.

Glydant® is a preservative system that provides excellent bactericide and mild fungicide for product protection. This cost-effective, water soluble system can be easily incorporated into a broad number of personal care products and offers water-white/color stability, heat stability, and compatibility with anionic, nonionic and cationic systems.

Geogard® Boost PHC is an innovative one-step preservation solution, based on Phenoxyethanol. It delivers a broad spectrum of microbial protection with reduced levels of Phenoxyethanol in cosmetics applications like creams, lotions, moisturizers and conditioners.A single dose liquid solution which simplifies manufacturing logistics and helps meeting ever-changing market demand. Geogard® Boost PHC is easily formulated into conditioners and lotions, and is effective at a pH range of 5-8.INCI Name: Phenoxyethanol (CAS: 122-99-6), Propylene Glycol Caprylate (CAS: 68332-79-6 / 31565-12-5)Key Benefits of Geogard® Boost HPC:Optimized microbial performance at lower levels of PhenoxyethanolEnhanced efficacy spectrum and increased speed of kill compared to Phenoxyethanol alone Simplified manufacturing process (easily dilutable liquid concentrate)Applications Include: Bath & ShowerBody CareHair CareHair ConditioningSkin Care

Geogard® ECT is a unique, patented combination of benzyl alcohol, salicylic acid, glycerin and sorbic acid, which are well accepted in a wide range of personal care products. The novel composition of this antimicrobial blend offers a low cost in use as well as broad spectrum protection in a diverse range of products against Gram-positive and Gram-negative bacteria, yeast and molds at wide pH ranges. Geogard® ECT has a wide range of global regulatory acceptance for personal care products.

Glydant Plus® Liquid is a synergistic preservation system that combines two well-known and traditional chemistries for personal care. The combination of DMDM Hydantoin and Iodopropynyl Butylcarbamate allow for a dual mode of action, offering broad spectrum efficacy. These chemistries been used in personal care for years. This product contains the same amount of active ingredient as Lonza’s Glydant Plus® but is offered as a liquid form.

Glydant® LTD is a high performance preservative for cosmetics and toiletries that is fully compatible with cationic, anionic or nonionic surfactants, emulsifiers and proteins. Glydant™ LTD has applications in hair care, shaving, lotions, powders, baby products, eye makeup, sun products, creams, and other raw materials.

Benzethonium Chloride USP is a reliable and trusted cationic antimicrobial that can also be used as a personal care preservative. Benzethonium Chloride USP offers greater efficacy, mildness, and safety versus competitive chemistries as an active antimicrobial ingredient, coupled with global-acceptance as a fast-acting preservative.

Zinc Omadine™ 48% FPS (Fine Particle Size) offers bactericide-fungicide efficacy in shampoos, conditioners and leave-on products. Zinc Omadine™ products are highly active, broad spectrum antimicrobial agents that are registered around the world for use in both personal care as well as industrial product applications.

Cosmocil® CQ is a broad spectrum, fast-acting antibacterial. A 20% aqueous solution of poly(hexamethylenebiguanide) hydrochloride, also known as PHMB, Cosmocil® CQ is an effective preservative for personal care formulations, active against a wide range of both Gram-positive and Gram-negative bacteria.

SPECTRADYNE™ is a strong bactericide that can be used in a variety of personal care applications. It is extremely mild to skin and is non- sensitizing. Low use levels are required for an excellent effect in finished formulations.

Mikrokill® COS is a unique, patented combination of three components (Phenoxyethanol, Chlorphenesin and Caprylyl Glycol), which are well accepted in a wide range of personal care products. Phenoxyethanol is a widely used and versatile preservative. Chlorphenesin is a known broad spectrum preservative and Caprylyl Glycol provides biological synergism with moisturizing and wetting capabilities.

Coltsfoot Leaf Extract is a natural extract of the leaves of Tussilago Farfara. Coltsfoot leaves contain mucilage, cystine, sulfur and silica. Mucilage is an anti-inflammatory and silica is effective for soothing the scalp and clearing dandruff. Coltsfoot is also known to have antimicrobial properties. It can be used in formulations for personal care products such as soothing lotions, dandruff control shampoos or in many other types of applications.

Bio-Botanica, Inc. Licorice Root In Propylene Glycol is a product belonging to the plant family Fabaceae. Its Latin name is Glycyrrhiza glabra. The key chemical constituents include glycyrrhizin, glycyrrhetic acid, isoliquiritin, and isoflavones. This product falls into the functional categories of flavors, digestive health, women's health, immune support, and respiratory health. It is also relevant in the cosmetic and personal care functional category, particularly for skin care.

Coltsfoot Leaf Extract is a natural extract of the leaves of Tussilago Farfara. Coltsfoot leaves contain mucilage, cystine, sulfur and silica. Mucilage is an anti-inflammatory and silica is effective for soothing the scalp and clearing dandruff. Coltsfoot is also known to have antimicrobial properties. It can be used in formulations for personal care products such as soothing lotions, dandruff control shampoos or in many other types of applications.

Bio-Botanica, Inc. Echinacea In Butylene Glycol is a product under the plant family Asteraceae, with the Latin name Echinacea angustifolia. It contains alkylamides and caffeic acid derivatives, along with polysaccharides and glycoproteins. This product is used in the food/beverage/dietary supplement functional category of immune support and has applications in the cosmetic/personal care functional category for skin care.

Calendula Flower Extract is a natural extract of the flowers of Calendula Officinalis. Calendula has anti-inflammatory, antibacterial and antiseptic properties. It has been used to treat dry or damaged skin, heal wounds, burns, eczema and other inflammatory skin conditions. This product is recommended for bath products, body washes, face washes, and shampoos.

Bio-Botanica, Inc. Hops Strobile In Butylene Glycol is a product under the plant family Cannabaceae, with the Latin name Humulus lupulus. It contains humulones, bisabolene, caryophyllene, farnesene, and elemene. This product is used in the food/beverage/dietary supplement functional categories of digestive support and sleep support. Additionally, it has applications in the cosmetic/personal care functional category for skin care.

Calendula Flower Extract is a natural extract of the flowers of Calendula Officinalis. Calendula has anti-inflammatory, antibacterial and antiseptic properties. It has been used to treat dry or damaged skin, heal wounds, burns, eczema and other inflammatory skin conditions. This product is recommended for bath products, body washes, face washes, and shampoos.

Bio-Botanica, Inc. Guarana Seed In Propylene Glycol is a product under the plant family Sapindaceae, with the Latin name Paullinia cupana. It contains caffeine, xanthine alkaloids, theophylline, and theobromine. Similar to the previous Guarana Seed product, it is used in the food/beverage/dietary supplement functional categories of cardiovascular support, weight management, nervous system support, and digestive support.

A proprietary synergistic combination of botanical extracts. Biopein® has potent anti-microbial properties, making it an ideal ingredient for natural personal care and cosmetic applications.

Bio-Botanica, Inc. Guarana Seed In Glycerin is a product under the plant family Sapindaceae, with the Latin name Paullinia cupana. It contains key chemical constituents such as caffeine, xanthine alkaloids, theophylline, and theobromine. This product serves the food/beverage/dietary supplement functional categories of cardiovascular support, weight management, nervous system support, and digestive support.

Calendula Flower Extract is a natural extract of the flowers of Calendula Officinalis. Calendula has anti-inflammatory, antibacterial and antiseptic properties. It has been used to treat dry or damaged skin, heal wounds, burns, eczema and other inflammatory skin conditions. This product is recommended for bath products, body washes, face washes, and shampoos.

Bio-Botanica, Inc. Catnip Herb In Butylene Glycol is a product under the plant family Lamiaceae, with the Latin name Nepeta cataria. It contains iridoids, tannins, volatile oils, mainly comprising alpha- and beta-nepetalactone, citronellal, and geraniol. This product is intended for the food/beverage/dietary supplement functional category of digestive support.

Bio-Botanica, Inc. Guarana Seed In Butylene Glycol is a product under the plant family Sapindaceae, with the Latin name Paullinia cupana. It contains caffeine, xanthine alkaloids, theophylline, and theobromine. This product serves the food/beverage/dietary supplement functional categories of cardiovascular support, weight management, nervous system support, and digestive support.

Bio-Botanica, Inc. Lavender Flower In Propylene Glycol is a product from the Lamiaceae plant family, with the Latin name Lavandula angustifolia. Key chemical constituents include volatile oil (up to 3%) containing over 40 constituents, including linalyl acetate, cineole, linalool, nerol, and borneol. It also contains flavonoids, tannins, and coumarins. This product serves functional roles in the categories of flavors and mood and stress support within the food, beverage, and dietary supplement industry. Additionally, it is used in the cosmetic and personal care industry, primarily for fragrance, skin, and hair applications.

Suprapein® is a proprietary synergistic blend of botanical extracts, which have the ability to inhibit a wide range of microorganisms. It is a natural preservative made up of a proprietary blend for multiple personal care and cosmetic applications, crémes, shampoos, soaps, and lotions.

Bio-Botanica, Inc. Hops Strobile In Propylene Glycol is a product under the plant family Cannabaceae, with the Latin name Humulus lupulus. It contains humulones, bisabolene, caryophyllene, farnesene, and elemene. Similar to the previous Hops Strobile product, it is used in the food/beverage/dietary supplement functional categories of digestive support and sleep support. Additionally, it has applications in the cosmetic/personal care functional category for skin care.

Bio-Botanica, Inc. Hops Strobile In Glycerin is a product under the plant family Cannabaceae, with the Latin name Humulus lupulus. It contains humulones, bisabolene, caryophyllene, farnesene, and elemene. This product is intended for the food/beverage/dietary supplement functional categories of digestive support and sleep support. It also has applications in the cosmetic/personal care functional category for skin care.

Bio-Botanica, Inc. Lavender Flower In Glycerin is a product from the Lamiaceae plant family, with the Latin name Lavandula angustifolia. Key chemical constituents include volatile oil (up to 3%) containing over 40 constituents, including linalyl acetate, cineole, linalool, nerol, and borneol. It also contains flavonoids, tannins, and coumarins. This product serves functional roles in the categories of flavors and mood and stress support within the food, beverage, and dietary supplement industry. Additionally, it is used in the cosmetic and personal care industry, primarily for fragrance, skin, and hair applications.

Bio-Botanica, Inc. Licorice Root In Butylene Glycol is a product belonging to the plant family Fabaceae. Its Latin name is Glycyrrhiza glabra. The key chemical constituents include glycyrrhizin, glycyrrhetic acid, isoliquiritin, and isoflavones. This product falls into the functional categories of flavors, digestive health, women's health, immune support, and respiratory health. It is also relevant in the cosmetic and personal care functional category, specifically for skin care.

Oregon Grape Root Extract is a natural extract of the root of Mahonia Aquifolium. Oregon grape root contains the alkaloid berberine which is known as an anti-inflammatory and anti-bacterial used in the treatment of infection. It is excellent for use in skin care, anti-aging, soothing, shampoo, soaps, bath and shower products.

Neopein® is an all natural preservative for multiple personal care and cosmetic applications, crémes, shampoos, soaps, lotions, etc. It is an ideal alternative to synthetic preservatives. Neopein® is a proprietary blend of botanical extracts with broad spectrum antimicrobial activity.

Bio-Botanica, Inc. Peppermint Leaf In Propylene Glycol is a product from the Lamiaceae plant family, with the Latin name Mentha x piperita. Their key chemical constituents include flavonoids, including luteolin, menthoside, volatile oil including menthol, menthone, phenolic acids, and triterpenes. This product serve functional categories in food, beverages, and dietary supplements, such as flavors, digestive support, and immune support. They are also used in the cosmetic and personal care industry, with applications in fragrance, skin, and nervous system support.