Products in Cosmetic Actives: Whitening Agent

TEGO® Cosmo EPL is a Multi-functional amino acid for beauty renewal.

Dermawhite® NF LS 9410 is a skin brightening complex based on extracts of papaya, guava, and saxifrage blossoms. It harnesses the power of natural ingredients to brighten the complexion while respecting the skin's natural characteristics and health. This active delivers a skin brightening action that is three times stronger than kojic acid, a commonly used active in the skin brightening market. Dermawhite™ is a safe and healthy ingredient that effectively promotes the appearance of a healthy glow, providing the best of both worlds.

Dermawhite® WF C is based on the extracts of papaya, guava, and saxifrage blossoms. Dermawhite™ WF C uses the power of nature to noticeably brighten the complexion while respecting the skin’s natural characteristics in health. This complex delivers a skin brightening action that is three times higher than that of kojic acid, a commonly used and well-known active ingredient on the skin brightening market. Dermawhite™ WF C is the best of both worlds: a safe and healthy ingredient that effectively gives skin the appearance of a healthy glow.

GinsenoLite™ G is an active ingredient derived from Korean ginseng, enriched with bioactive components called ginsenosides, which have a similar structure to plant polyphenols. GinsenoLite™ G is standardized based on the content of ginsenosides. This active ingredient prevents melanocytes in the skin from producing and accumulating melanin pigments, and has been clinically shown to improve skin whitening. Thanks to its excellent antioxidant properties, Ginsenolite™-G decreases the oxidative damage caused by blue light.

Bio-Botanica, Inc. Licorice Root In Propylene Glycol is a product belonging to the plant family Fabaceae. Its Latin name is Glycyrrhiza glabra. The key chemical constituents include glycyrrhizin, glycyrrhetic acid, isoliquiritin, and isoflavones. This product falls into the functional categories of flavors, digestive health, women's health, immune support, and respiratory health. It is also relevant in the cosmetic and personal care functional category, particularly for skin care.

Bio-Botanica, Inc. Licorice Root In Glycerin is a product under the plant family Fabaceae, with the Latin name Glycyrrhiza glabra. It contains glycyrrhizin, glycyrrhetic acid, isoliquiritin, isoflavones. This product is used in the food/beverage/dietary supplement functional categories for flavor, digestive support, women's health support, immune support, and respiratory support. It also has applications in the cosmetic/personal care functional category for skin care.

Bio-Botanica, Inc. Licorice Root In Butylene Glycol is a product belonging to the plant family Fabaceae. Its Latin name is Glycyrrhiza glabra. The key chemical constituents include glycyrrhizin, glycyrrhetic acid, isoliquiritin, and isoflavones. This product falls into the functional categories of flavors, digestive health, women's health, immune support, and respiratory health. It is also relevant in the cosmetic and personal care functional category, specifically for skin care.

MacDerma™ AZA (Azelaic Acid) is a saturated dicarboxylic acid that exists as a white powder. Azelaic Acid is commonly derived from natural ingredients such as wheat, rye, and barley. It can also come from the Malassezia furfur (also known as Pityrosporum ovale), which is a yeast that lives on normal skin. It is the bacterial degradation of nonanoic acid that yields azelaic acid. MacDerma™ AZA has been known to reduce the appearance of skin discoloration and redness, acne, and other skin blemishes.

SkinBrite-30™ is a water soluble, diamide salt of azelaic acid that improves the technical characteristics for formulation. Azelaic acid itself has very poor water solubility, however, it is found in many grain proteins and is a beneficial component of the skin. Azelaic acid in the skin is a signaling compound for inflammation and induces the production of salicylic acid. The Potassium Azeloyl Diglycinate derivative is a safe, highly effective and multifunctional cosmetic ingredient. As the diamide potassium salt, SkinBrite-30 is a new ingredient that resolves many of the formulation difficulties of azelaic acid. SkinBrite-30 offers water solubility, requires less dosage, and has beneficial effects against inflammation.

G-Hexuron is the stabilized form of Vitamin C that can be topically applied to the skin in advanced formulations specifically targeted for anti-aging and photo-protection benefits. G-Hexuron is the water soluble, Vitamin C, 2-derivative with superior formulation stability. G-Hexuron is both bioavailable and bioactive in its 2-glucoside form and has been shown to be more bio-persistent over time vs. Vitamin C. G-Hexuron is photo-protective, visibly lightens skin and possesses anti-aging properties similar to Vitamin C.

SAP-Hexuron™ (SAP) is a stable vitamin C derivative that is cleaved enzymatically in the skin to release active vitamin C. It is produced by direct phosphorylation of ascorbic acid sodium salt where I-acorbic acid is suspended in oxygenated, nonhydroxylic solvent together with sodium and then treated with a phosphorylating agent. SAP-Hexuron™ is soluble in water and does not degrade in aqueous formulas. It is also an antioxidant that reduces oxidative stress by neutralizing free radicals, effectively slowing down the aging process and formation of fine lines and wrinkles.

SmartLipids are submicrometer lipid particles consisting of a complex mixture of solid waxes and liquid oils. The full range of action of glabridin can be exploited as it is protected physically from degradation caused by external factors such as light and oxygen. Furthermore, the patented technology of SmartLipids can support the natural skin barrier and increase the bioavailability of active dermal ingredients. Thanks to their submicrometer size and lipid properties, SmartLipids adhere well to the skin and guarantee prolonged release of the encapsulated glabridin.

NanoWhite is a liposomal preparation combining powerful whitening ingredients and it regulates the pigmentation process through complementary pathways: Natural arbutin from bearberry powerfully inhibits tyrosinase, the key enzyme of the pigmentation process, while glutathione and vitamin C reinforce NanoWhite's activity with their whitening and antioxidant properties. NanoWhite is therefore a safe yet powerful whitening ingredient ideal for reducing and preventing pigmentation disorders.Benefits: Safely inhibits the pigmentation process. Reduces melanin synthesis. For a luminous, even skin tone.

SulforaWhite is a liposomal preparation of Swiss garden cress sprouts that is rich in sulforaphane, a powerful antioxidant phytonutrient. SulforaWhite effectively inhibits pigmentation by targeting the two key reaction steps in the melanin cascade: it not only neutralizes reactive oxygen species but also inhibits α-MSH, a natural hormone which stimulates skin pigmentation. SulforaWhite reduces the effects of daytime stressors and helps to prevent the formation of melanin for a brighter, more luminous skin complexion.Benefits: Effectively inhibits melanin formation. Provides exceptional brightening benefits. Fades the appearance of age spots and discolorations. Reduces the effects of daytime stressors. Evens skin tone.

HyWhite is whitening hyaluronic acid. Very low molecular weight hyaluronic acid modified by alpha linolenic acid. HyWhite acts as highly effective anti-pigmentation agent.

Arbutin is a very effective skin whitening agent with distinct antioxidant properties. It controls the build-up of senile keratosis, freckles as well as pigmented lesions and is an ideal active ingredient in skin lightening and anti-aging cosmetics such as creams, lotions, essences, face masks and foundations.

GfN Selco Ethyl Ascorbic Acid is comprised of 3-O-Ethyl Ascorbic Acid. It is commonly used as Anti Aging Agent, Antioxidant, Whitening Agent and Skin Conditioning Agent for a variety of applications in Skin Care. Key benefits in use include: Anti-aging, Anti-inflammatory, Antioxidant, Skin lightening and Skin whitening. Approved for use in IECIC Listed (China) and EC Cosing Listed (Europa).

Papain is a natural enzyme from the seeds of the papaya fruit. it is essential for the plants natural defense against varmints. Papain is an effective peel-off substrate for the renewal of soft skin. This makes the skin look fresh and younger after the treatment. Suitable for: Anti aging, Whitening, Anti acne. (Enzyme activity minimum 800.000 u/g)

Glycoin® natural is a 100% natural multifunctional anti-aging and cell boosting active ingredient. It shows strong activity on aged and stressed skin cells with powerful rejuvenation properties. Old skin cells are re-vitalized and behave like young cells again. Sluggish cells functions and metabolic activity are boosted and stimulated. Glycoin® natural is the perfect multifunctional anti-aging active ingredient for mature or tired and stressed skin - reactivating the power of youth by the model of nature.

Ectoin® natural is a very safe, 100% natural and multifunctional cosmetic active ingredient with outstanding cell protection and anti-aging properties. Various in vivo and in vitro studies as well as clinicaltrials underline the extraordinary efficacy of Ectoin® natural. Ectoin® natural was discovered in 1985 as the self-defense and survival substance of microorganisms living in a saltlake in Wadi El Natrun (Egyptian desert).

BioWhite™ ABT is a skin beautifying and whitening agent which can effectively and selectively inhibit tyrosinase activity, therefore eliminate the formation of melanin and hyperpigmentation without altering the normal growth of the epidermic cell or inhibiting the expressing of tyrosinase itself.

BioWhite™ VCG is a stable Vitamin C derivative and hydrolyzed by α-glucosidase. BioWhite™ VCG has high water solubility, while retaining the natural biologic functions of Vitamin C. It helps inhibit discoloration and degradation, and retains all the biological activity. BioWhite™ VCG is used not only for whitening, but also to brighten the skin, which plays a role in protecting the skin in sunscreen products. It is also used as a anti-wrinkle agent in daily moisturizing and sunscreen products to prevent photo-aging.

SMA'RT® VCL is an oil soluble vitamin C that has an extreme stability profile. It is used as a whitening agent to brighten and even skin tones. SMA'RT® VCL helps to reduce age spots. Due to its known ability to penetrate into skin for increased bioavailability, it aids in collagen development-reducing the appearance of fine lines and wrinkles. It is known to act as an antioxidant. It is heat and oxygen stable. Sample Size: 50g

Tranexamic Acid (TA) is a skin whitening agent which also inhibits protease and stops melanin production by inhibiting tyrosinase activity. This synthetic amino acid that functions as a skin conditioning agent also serves as an astringent and has proven effective action against UV-induced hyperpigmentation.

Glutathione is a skin whitener booster that is produced naturally by the liver but it’s also found in fruits, vegetables and meats. Glutathione is an antioxidant made from glycine, glutamic acid and cysteine. This compound is involved in tissue building and repairs processes, the production of proteins and chemicals needed in the body for the immune system.

Lactic acid is an organic acid naturally occurring and it is called a AHA (alpha hydroxyl acid). It is the AHA most frequently used for skin peel products.

Ferulic acid is a phenolic derivative found in the cell walls of plants such as wheat, rice, peanuts, oranges and apples. It seems to be particularly abundant in coffee and amaranth. It is an antioxidant that can seek and destroy several different types of free radical - ‘superoxide’, ‘hydroxyl radical’, and nitric oxide. Ferulic acid is suggested to suppress melanin generation by antagonizing tyrosine because its chemical structure is similar to tyrosine. Synergizes with other antioxidants especially vitamins C and E. When used with these vitamins, prevents them from breaking down or becoming ineffective. This super antioxidant has also been shown to protect against a variety of cancers, bone degeneration, and menopausal symptoms such as hot flashes.

Retionic Acid is a derivative of Vitamin A and part of the retinoid family. Retinoids belong to the terpene family which is commonly found in the flora and fauna. Terpenes occur in aromatic substances and spice plants, cellular structuring substances, hormones and vitamins. Natural Vitamin A and its derivatives have important roles in maintaining good vision and overall healthy skin as they stimulate skin cell growth and improves aged skin by reducing coarseness and wrinkles. This product can be used in anti-acne cosmetics. It maybe has little burning feel to use this kind of cosmetics on skin.

Retinol or retinyl acetate is derived ester form of Vitamin A. It helps rough- aged skin become thinner and normalizes the metabolism of cells. Retinyl Acetate is known to be essential for normal skin development as its liposoluble vitamin character aids in improving epidermis histocyte growth and health.

Polyglutamic Acid (PGA) is classified as a long lasting natural moisturizer with whitening properties. This multi-functional and biodegradable polymer is water soluble. PGA has proven to be a better moisturizer than that of hyaluronic acid and collagen protein as it restores skin elasticity and smooth skin wrinkles. Additionally, this anionic amino acid can it provide smoothness, silkiness, protection against external aggressions and provide soothing response against allergies and inflammations.

iVit SAP is an active vitamin C derivative known to impart whitening and brightening effects on the skin. It can promote ossein synthesis and restrain lipid oxidation. However, its color is easily changed by oxidation, so the use of Vitamin C is limited.

Kojic acid is a kind of specialized inhibitor for melanin. It can prevent the tyrosinase activity through synthesizing with copper ion in the cells after it enters skin cells. So, it is used for skin lightening and anti-melasma. Effective for inhibiting melanin production, tyrosinase inhibitor. At present it is assigned into various kinds of cosmetics for curing freckles, spots on the skin of older people, pigmentation and acne. It also eliminates free radicals and strengthens cell activity.

Glycyrrhiza Glabra is used as a natural whitening emollient. It inhibits tyrosinase activity and oxidizing enzymes. This extract has been used as an anti-inflammatory and antioxidant since licochalcone-a molecule contained in licorice root extract- aids in controlling oil production and helps soothe acne-prone skin. Glabridin possesses similar abilities as SOD(Super Oxide Dismutase), meaning it can remove free radicals. Additionally, it has antioxidant properties similar to Vitamin E.

Capryloyl Salicylic Acid is an ester form of salicylic acid which is a BHA and it works as an exfoliant. Salicylic acid is also used as to improve skin thickness and collagen production. This ester form is used as a skin conditioning agent that works by enhancing the appearance of damaged skin by removing dead cells, especially dryness as it reduces the flaking and restores the elasticity. Because of this, CSA is used in anti-aging, whitening, anti-acne and anti-wrinkle cosmetic formulations. Additionally, this analog is used as a preservative and has been categorized as an exfoliant, an anti-inflammatory and an antimicrobial. As a keratolytic agent, it exfoliates the skin by causing the cells of the epidermis (upper layer of skin) to shed more easily, making room for new cell growth. Higher concentrations (8-12%) of topically applied CSA can effectively remove warts. Studies have documented concentrations as low as 2% to improve skin thickness, collagen production, wrinkling, roughness and hyperpigmentation over a time period of just 6 months. A study showed a significant improvement in wrinkles in 41% of the subjects who regularly used a CSA peel, and a substantial lightening of hyperpigmentation in 46% of the CSA users (compared to only 31% and 34%, respectively, for those who used glycolic peels). Unlike alpha hydroxyl acids, which are water soluble, beta hydroxyl acids (and its esters) are lipid (oil) soluble. This means that they not only exfoliate the upper layer of skin, but also penetrate deep through the epidermis to exfoliate the dead skin cells and excess oil built up in the pores. For this reason, CSA acid is frequently used to treat blackheads, whiteheads and acne. Yet its keratolytic ability is not the only reason for why it is so often administered to treat blemishes and breakouts. This ingredient also functions as both an antimicrobial and anti-inflammatory agent, making it an ideal anti-acne ingredient. While many other exfoliants (i.e. AHA’s) often irritate the skin, salicylic acid does just the opposite by reducing inflammation.

iWhite Arbutin is a pure, water-soluble, crystalline, white to offwhite powder for cosmetic application. iWhite Arbutin ensures an even and lighter skin tone, it reduces the degree of skin tanning after UV exposure, and it also helps to minimize the appearance of spots. Alpha Arbutin blocks epidermal melanin biosynthesis by inhibiting enzymatic oxidation of Tyrosine and Dopa.

Phloretin can fade melanin, making the skin whiter, with proven effects superior to kojic acid and arbutin. Additionally, phloretin is commonly used as a new type of whitening agent in cosmetics, and has many biological applications, including antioxidant activity.