Products in Cosmetic Actives: Anti-Aging Products

Bio-Botanica, Inc. Hawthorn Berry In Propylene Glycol is a product under the plant family Rosaceae, with the Latin name Crataegus oxyacantha. It contains polyphenols, flavonoids, epicatechin, hyperoside, quercetin, rutin, and isoquercitrin. This product is used in the food/beverage/dietary supplement functional categories of digestive support, mood & stress support, cardiovascular support, and detox support.

Bio-Botanica, Inc. Olive Leaf In Glycerin is a product in the plant family Oleaceae, with the Latin name Olea europaea. Its key chemical constituents include oleuropein, oleasterol, and leine. This product is intended for the food/beverage/dietary supplement functional categories of immune support, cardiovascular support, and blood sugar regulation.

White Tea Extract is a natural extract of the young leaves of Camellia Sinensis. White tea contains antioxidants and is effective for protecting skin cells against damage from sun exposure. White tea has been found to be effective in protecting the skin from oxidative stress and immune cell damage most likely due to its antioxidant properties. This product is excellent for use in anti-aging products as well as sun protection products. It is useful for acne treatment as well.

Bio-Botanica, Inc. Gotu Kola In Butylene Glycol is a product from the plant family Apiaceae, with the Latin name Centella asiatica. Its key chemical constituents include pentacyclic triterpenes, mainly asiaticoside, madecassoside, asiatic and madecassic acids. This product is categorized for use in food, beverages, and dietary supplements for immune, digestive, respiratory, and cardiovascular support. It is also used in the cosmetic and personal care industry for skin care.

Bio-Botanica, Inc. Rosemary Leaf In Glycerin is a product under the plant family Labiatae, with the Latin name Rosemarinus officinalis. It contains caffeic acid, alkaloids, flavonoids, and phenols. This product serves the food/beverage/dietary supplement functional categories of flavors and cognitive support. Additionally, it can be used in the cosmetic/personal care functional category for fragrance and skin care.

Oregon Grape Root Extract is a natural extract of the root of Mahonia Aquifolium. Oregon grape root contains the alkaloid berberine which is known as an anti-inflammatory and anti-bacterial used in the treatment of infection. It is excellent for use in skin care, anti-aging, soothing, shampoo, soaps, bath and shower products.

Bio-Botanica, Inc. Fo-Ti Root In Butylene Glycol is a product under the plant family Polygonaceae, with the Latin name Fallopia multiflora. It contains key chemical constituents, including anthraquinones, phospholipids, tannins, and tetrahydroxystilbene glucoside. This product serves the food/beverage/dietary supplement functional categories of cardiovascular support, detox support, and mood & stress support.

Bio-Botanica, Inc. Gotu Kola In Propylene Glycol is a product from the plant family Apiaceae, with the Latin name Centella asiatica. Its key chemical constituents include pentacyclic triterpenes, mainly asiaticoside, madecassoside, asiatic and madecassic acids. This product is categorized for use in food, beverages, and dietary supplements for immune, digestive, respiratory, and cardiovascular support. It is also used in the cosmetic and personal care industry for skin care.

Bio-Botanica, Inc. Cactus Grandiflorus Flower In Propylene Glycol is a product in the plant family Cactaceae, with the Latin name Cereus grandiflorus. Its key chemical constituents include betacyanins and flavonoid glycosides. This product falls under the food/beverage/dietary supplement functional categories of cardiovascular support and women's health.

MacDerma™ AZA (Azelaic Acid) is a saturated dicarboxylic acid that exists as a white powder. Azelaic Acid is commonly derived from natural ingredients such as wheat, rye, and barley. It can also come from the Malassezia furfur (also known as Pityrosporum ovale), which is a yeast that lives on normal skin. It is the bacterial degradation of nonanoic acid that yields azelaic acid. MacDerma™ AZA has been known to reduce the appearance of skin discoloration and redness, acne, and other skin blemishes.

MacPeptide™ 3000 peptides synergize to promote synthesis of collagen and is an anti-wrinkle peptide solution that promotes collagen production, tightens the skin and reduces wrinkles. MacPeptide™ 3000 also provides moisturization and skin repair benefits.

Bee Pollen Extract is a natural extract of Bee Pollen. Bee pollen is excellent for use in skin care, it can be used in anti-aging products as a means to help nourish and renew the skin. This product can also be used for body care and bath products. It is used in eye shadow, lipstick and blush formulation.

SAP-Hexuron™ (SAP) is a stable vitamin C derivative that is cleaved enzymatically in the skin to release active vitamin C. It is produced by direct phosphorylation of ascorbic acid sodium salt where I-acorbic acid is suspended in oxygenated, nonhydroxylic solvent together with sodium and then treated with a phosphorylating agent. SAP-Hexuron™ is soluble in water and does not degrade in aqueous formulas. It is also an antioxidant that reduces oxidative stress by neutralizing free radicals, effectively slowing down the aging process and formation of fine lines and wrinkles.

MacPeptide™ Syn6 is an anti-wrinkle peptide solution that helps with wound recovery, smoothing lines and reducing wrinkles. MacPeptide™ Syn6 promotes synthesis of collagen, fibronectin, laminin and hyaluronic acid smoothing wrinkles and moisturizing the skin.

MacDerma™ FA is found in the seeds and leaves of most plants such as oats, wheat and rice. It can also be found in coffee, apples, peanuts, artichoke, pineapple and oranges. It is an antioxidant which make it especially useful in the formulation of anti-aging cosmetics. MacDerma™ FA is an antioxidant that can destroy several different types of free radicals such as superoxide, hydroxyl radical and nitric oxide.

SkinBrite-30™ is a water soluble, diamide salt of azelaic acid that improves the technical characteristics for formulation. Azelaic acid itself has very poor water solubility, however, it is found in many grain proteins and is a beneficial component of the skin. Azelaic acid in the skin is a signaling compound for inflammation and induces the production of salicylic acid. The Potassium Azeloyl Diglycinate derivative is a safe, highly effective and multifunctional cosmetic ingredient. As the diamide potassium salt, SkinBrite-30 is a new ingredient that resolves many of the formulation difficulties of azelaic acid. SkinBrite-30 offers water solubility, requires less dosage, and has beneficial effects against inflammation.

Bee Pollen Extract is a natural extract of Bee Pollen. Bee pollen is excellent for use in skin care, it can be used in anti-aging products as a means to help nourish and renew the skin. This product can also be used for body care and bath products. It is used in eye shadow, lipstick and blush formulation.

L-Hexuron™ is a superior vitamin C derivative. It is very stable, and is easilyconverted to the active form by enzymes in the skin. The ethyl substituent forms an ether with the 3-hydroxyl group of the ascorbic acid, which results in much higher stability. L-Hexuron is amphiphilic which makes it compatible in a broad array of emulsion systems and clear lotions.

MacPeptide™ Copper peptide solution contains the molecule consisting of GHK (Gly-L-His-L-Lys) and Cu and has both hair and skin benefits. MacPeptide™ Copper stimulates fibrolasts to produce collagen and mucopolysaccharide which leads to tighter, smoother skin reducing fine lines and wrinkles. It promotes the expression of hair growth factor by activating hair follicle tissues which regulates hair growth. MacPeptide™ Copper also scavenges for free radicals providing UV and anti-inflammatory protection.

Bio-Botanica, Inc. Red Clover Tops In Glycerin is a product in the plant family Fabaceae, with the Latin name Trifolium pratense. Its key chemical constituents include isoflavones. This product falls under the food/beverage/dietary supplement functional categories of respiratory support, sexual health, cardiovascular support, and bone & joint health.

Beta-Glucan M™ also called “Sodium Carboxymethyl Beta-Glucan” is the sodium salt of a carboxymethyl ether of Beta-Glucan. It is commonly used as a binding agent and rheological modifier in personal care formulations. It is known to soothe irritated skin, support the skin’s own antioxidant activity, protect the skin from environmental damage, and help the skin to retain moisture.

MacDerma™ ALA is found in healthy foods such as spinach, chard, collard greens and broccoli, foods often deficient in standard American diets. It is an antioxidant that is found in every human cell. MacDerma™ ALA at 5 % has been shown to reduce fine lines caused by sun damage.

Bio-Botanica, Inc. Ginseng Root American, In Glycerin is a product derived from the plant family Araliaceae with the Latin name Panax quinquefolius. Its key chemical constituents include ginsenosides, which are terpenoid saponins. This product is associated with functional categories in food, beverage, and dietary supplements, including flavors, digestive support, sexual health, and nervous system support. In cosmetic and personal care, it is related to skin care. American ginseng is native to the eastern United States and grows in the shade of northern hardwood forests. It contains beneficial constituents like ginsenosides and polysaccharides. American ginseng is considered a 'yin tonic,' known for its cooling and calming properties, in contrast to the warming and stimulating characteristics of Asian ginseng.

Aloe Vera Phytogel is a natural extract of Aloe barbedensis. Known for its antiseptic healing properties, aloe is an excellent humectant which makes it beneficial for dry or damaged skin. Its moisturizing properties aid in promoting the healing of wounds, burns, eczema and other inflammatory skin conditions. This product is recommended for lip and lip care products, bath products, body washes, and face washes.

Bio-Botanica, Inc. Ginkgo Leaf In Glycerin is a product sourced from the plant family Ginkgoaceae, with the scientific name Ginkgo biloba. It contains essential chemical constituents, including terpene lactones, ginkgo flavone glycosides, ginkgetin, bilobetin, and sciadopitysin. This product serves various functions within the food, beverage, and dietary supplement industry, primarily contributing to mood and stress management, cognitive support, respiratory health, and cardiovascular well-being.

NaturePep® Ganoderma reduces crow’s feet wrinkles and roughness for smoother-looking skin. Repairs dermal degradation and prevents skin’s oxidative & cellular damage caused by aging, UV, environmental stress, and pollutants. Decreases melanin concentration on dark spots for an even skin complexion. INCI: Hydrolyzed Ganoderma Lucidum (Mushroom) Extract Suggested use level: 1 - 5%; add in the water or cool-down phase, when less than 40°C. For a formulation, the ideal pH range is 4.0 - 7.0. This product is gluten-free and non-GMO.

TRI-K Industries, Inc. HempTein Z NPNF® is a natural, sustainable, and organic source from upcycling hemp seed biomass. This product is for skin and hair. On the skin, it improves texture by enhancing hydration. On hair, it repairs and smooths cuticles after chemical damage, making the hair more resilient. INCI: Hydrolyzed Cannabis Sativa Seed Extract Suggested use level: 1 - 4%; add in the water or cool down phase, when less than 40°C. For a formulation, the ideal pH range is 4.0 - 6.0. This product is gluten-free, non-GMO, and ECOCERT/Cosmos approved.

Fision® Instant Lift - Fast-acting, on-demand anti-aging. Uniform film provides even coverage throughout the skin. Instantly improves skin firmness, reduces the appearance of wrinkles, and smooths skin. It gives your skin instagratification for younger-looking skin. INCI: Water, Hydrolyzed Soy Protein, Acacia Senegal Gum, Xanthan Gum Suggested use level: 3 - 5%; add in the water or cool down phase. Incorporate at temperatures below 40°C. For a formulation, the ideal pH range is 4.5 - 7.0. This product is gluten-free, non-GMO, and Ecocert/Cosmos approved. Alternative Fision® SoyLift and Fision® SkinLift. These are no longer being promoted (slightly different INCI). Sold to existing customers only.

Fision® WrinkleFix fixes your wrinkles by protecting, fortifying, and renewing your skin. It is perfect for all skin types, including sensitive skin. Visibly minimizes deep wrinkles and fine lines. Reduces age spots for a more even complexion. Significant changes in wrinkles can be seen after 56 days giving brighter, and younger skin. INCI: Water, Hydrolyzed Rice Protein, Hydrolyzed Pea Protein, Glycine, Proline, Hydrolyzed Sodium Hyaluronate Suggested use level: 1 - 5%; add in the water or cool down phase. Incorporate at temperatures below 40°C. For a formulation, the ideal pH range is 4.0 - 7.0. This product is gluten-free and non-GMO.

TRIglyphix® Sense is a botanical-based active designed to quell the discomfort and redness associated with skin irritation. Based on DNA microarray analysis, in vitro, and in vivo studies, results show TRIglyphix® Sense delivers superior soothing properties while enhancing the expression of genes involved in barrier function, stress response, and repair mechanisms. INCI: Hordeum Vulgare Seed Extract Suggested use level: 2 - 5%; add in the water or cool down phase, when less than 40°C. For a formulation, the ideal pH range is 4.0 - 7.0. This product is gluten-free, Non-GMO, and Ecocert Cosmos approved.

NaturePep® Pea visibly reduces dark spots & hyperpigmentation. It will lighten the overall skin tone for a more uniform complexion. Smooths & evens texture for healthy, flawless-looking skin. INCI: Pisum Sativum (Pea) Extract Suggested use level: 1 - 5%; add in the water or cool down phase, when less than 40°C. For a formulation, the ideal pH range is 4.0 - 7.0. This product is gluten-free, non-GMO, and Ecocert/Cosmos approved.

DermalRx® Acetygen® (R10117) is a botanical active ingredient featuring Agrimonia eupatoria and Ampelopsis grossedentata extract with potent phytochemicals (including dihydromyricetin, myricetin, and other bioactive flavonoids). DermalRx® Acetygen® is a potent senolytic and broad-spectrum epigenetic modulator for applications in skin health and wellness, such as anti-aging products targeting oxidative, environmental, and inflammatory damage. DermalRx® Acetygen® enhances natural skin repair mechanisms to help eliminate dysfunctional senescent cells that contribute to signs of tissue aging. By regulating the histone deacetylase (HAT/HDAC) “switch”, DermalRx® Acetygen® epigenetically restores gene expression to levels found in younger skin for a renewed extracellular matrix (ECM). DermalRx® Acetygen® protects the skin from oxidative stress and inflammatory damage while rejuvenating the tissue for a youthful, healthy appearance. 

DermalRx® KBGA (R10017) is a proprietary blue-green algal extract with a unique combination of naturally-occurring repair active components for skin and hair moisturization and nourishment. Derived from Aphanizomenon flos-aquae (AFA), DermalRx® KBGA is rich in essential amino acids and fatty acids, proteins, antioxidants, and a full spectrum of minerals.Backed with comprehensive efficacy assays, DermalRx® KBGA increases the skin’s ability to maintain moisture at the skin barrier while protecting collagen and other extracellular matrix components (ECM, the structural foundation of the skin) from oxidative and proteolytic stress. With optimized bioactivity and bioavailability, DermalRx® KBGA addresses dry and damaged skin with applications in anti-aging and anti-wrinkle products, and nourishing, moisturizing skin and hair formulations. 

Tellirictin® (R10047) is a proprietary clove flower extract containing natural gallate-based pleiotropic compounds (tellimagrandin I and casuarictin) for multi-functional anti-aging performance. Tellirictin® addresses the many signs of aging by delivering brightening, anti-wrinkle, and moisturizing activities, while also protecting the skin from oxidative, inflammatory, proteolytic, and environmental stresses. Applications of Tellirictin® include anti-aging, anti-wrinkle, and skin-brightening regimens, soothing and calming products for sensitive skin, and pre- and post-sun care.   Tellirictin® prevents excessive melanin production to combat hyperpigmentation by inhibiting tyrosinase activity as efficiently as beta-arbutin. Tellirictin® protects collagen and other components of the extracellular matrix (ECM, the structural foundation of the skin) from damaging enzymes (MMPs and elastases) associated with environmental stressors such as environmental pollution and UV (sun) exposure. Tellirictin® modulates microRNAs involved in the beneficial regulation of DNA repair, barrier protection, and anti-inflammatory pathways. 

Pleiotanicals® Ellagicin®(R10068) is a botanically derived active ingredient containing proprietary acai and pomegranate “superfruit” extracts for antioxidant and anti-aging benefits. Ellagicin® is rich in ellagic acid, anthocyanins, and other natural antioxidants that provide protection from oxidative and proteolytic stress. Ellagicin® protects collagen and other components of the extracellular matrix (ECM, the structural foundation of the skin) from damaging enzymes associated with environmental stressors such as environmental pollution and UV (sun) exposure. Applications of Ellagicin® include anti-aging and anti-wrinkle regimens, soothing and calming products for sensitive skin, and pre- and post-sun care.

Pleiotanicals® Holy Basil OSP (R10110) is a proprietary extract of Ocimum sanctum (a plant used in Ayurvedic medicine) for pollution protection and aging prevention in the skin. Holy Basil OSP contains key active molecules, including polyphenols and pentacyclic triterpenoids, that protect against environmental pollution with anti-aging benefits. Holy Basil OSP is ideal for anti-aging, anti-wrinkle, de-stressing, and pollution/UV protection regimens, as well as soothing, calming products for sensitive skin.   Holy Basil OSP reduces a suite of inflammatory mediators in the skin typically induced by exposure to airborne particular matter (PM2.5). Holy Basil OSP protects the extracellular matrix (ECM, the structural foundation of the skin) against damaging oxidative, proteolytic, and inflammatory stress while also modulating collagen and other genes fundamental for ECM structure and integrity.