Products in Cosmetic Ingredients: Anti-Aging Products

MacDerma™ ALA is found in healthy foods such as spinach, chard, collard greens and broccoli, foods often deficient in standard American diets. It is an antioxidant that is found in every human cell. MacDerma™ ALA at 5 % has been shown to reduce fine lines caused by sun damage.

Aloe Vera Phytogel is a natural extract of Aloe barbedensis. Known for its antiseptic healing properties, aloe is an excellent humectant which makes it beneficial for dry or damaged skin. Its moisturizing properties aid in promoting the healing of wounds, burns, eczema and other inflammatory skin conditions. This product is recommended for lip and lip care products, bath products, body washes, and face washes.

Bio-Botanica, Inc. Ginseng Root American, In Glycerin is a product derived from the plant family Araliaceae with the Latin name Panax quinquefolius. Its key chemical constituents include ginsenosides, which are terpenoid saponins. This product is associated with functional categories in food, beverage, and dietary supplements, including flavors, digestive support, sexual health, and nervous system support. In cosmetic and personal care, it is related to skin care. American ginseng is native to the eastern United States and grows in the shade of northern hardwood forests. It contains beneficial constituents like ginsenosides and polysaccharides. American ginseng is considered a 'yin tonic,' known for its cooling and calming properties, in contrast to the warming and stimulating characteristics of Asian ginseng.

Bio-Botanica, Inc. Ginkgo Leaf In Glycerin is a product sourced from the plant family Ginkgoaceae, with the scientific name Ginkgo biloba. It contains essential chemical constituents, including terpene lactones, ginkgo flavone glycosides, ginkgetin, bilobetin, and sciadopitysin. This product serves various functions within the food, beverage, and dietary supplement industry, primarily contributing to mood and stress management, cognitive support, respiratory health, and cardiovascular well-being.

SPECTRADYNE™ is a strong bactericide that can be used in a variety of personal care applications. It is extremely mild to skin and is non- sensitizing. Low use levels are required for an excellent effect in finished formulations.

L-Hexuron™ is a superior vitamin C derivative. It is very stable, and is easilyconverted to the active form by enzymes in the skin. The ethyl substituent forms an ether with the 3-hydroxyl group of the ascorbic acid, which results in much higher stability. L-Hexuron is amphiphilic which makes it compatible in a broad array of emulsion systems and clear lotions.

MacPeptide™ Syn6 is an anti-wrinkle peptide solution that helps with wound recovery, smoothing lines and reducing wrinkles. MacPeptide™ Syn6 promotes synthesis of collagen, fibronectin, laminin and hyaluronic acid smoothing wrinkles and moisturizing the skin.

MacPeptide™ 3000 peptides synergize to promote synthesis of collagen and is an anti-wrinkle peptide solution that promotes collagen production, tightens the skin and reduces wrinkles. MacPeptide™ 3000 also provides moisturization and skin repair benefits.

TRI-K Industries, Inc. HempTein Z NPNF® is a natural, sustainable, and organic source from upcycling hemp seed biomass. This product is for skin and hair. On the skin, it improves texture by enhancing hydration. On hair, it repairs and smooths cuticles after chemical damage, making the hair more resilient. INCI: Hydrolyzed Cannabis Sativa Seed Extract Suggested use level: 1 - 4%; add in the water or cool down phase, when less than 40°C. For a formulation, the ideal pH range is 4.0 - 6.0. This product is gluten-free, non-GMO, and ECOCERT/Cosmos approved.

Fision® WrinkleFix fixes your wrinkles by protecting, fortifying, and renewing your skin. It is perfect for all skin types, including sensitive skin. Visibly minimizes deep wrinkles and fine lines. Reduces age spots for a more even complexion. Significant changes in wrinkles can be seen after 56 days giving brighter, and younger skin. INCI: Water, Hydrolyzed Rice Protein, Hydrolyzed Pea Protein, Glycine, Proline, Hydrolyzed Sodium Hyaluronate Suggested use level: 1 - 5%; add in the water or cool down phase. Incorporate at temperatures below 40°C. For a formulation, the ideal pH range is 4.0 - 7.0. This product is gluten-free and non-GMO.

NaturePep® Pea visibly reduces dark spots & hyperpigmentation. It will lighten the overall skin tone for a more uniform complexion. Smooths & evens texture for healthy, flawless-looking skin. INCI: Pisum Sativum (Pea) Extract Suggested use level: 1 - 5%; add in the water or cool down phase, when less than 40°C. For a formulation, the ideal pH range is 4.0 - 7.0. This product is gluten-free, non-GMO, and Ecocert/Cosmos approved.

TRIglyphix® Sense is a botanical-based active designed to quell the discomfort and redness associated with skin irritation. Based on DNA microarray analysis, in vitro, and in vivo studies, results show TRIglyphix® Sense delivers superior soothing properties while enhancing the expression of genes involved in barrier function, stress response, and repair mechanisms. INCI: Hordeum Vulgare Seed Extract Suggested use level: 2 - 5%; add in the water or cool down phase, when less than 40°C. For a formulation, the ideal pH range is 4.0 - 7.0. This product is gluten-free, Non-GMO, and Ecocert Cosmos approved.

Fision® EcoLatum S is a great alternative to petrolatum for hair, lip, sun, and skin care. Compatible with all types of emollients (mineral, vegetable, synthetic). Helps with high-viscosity products. This is a naturally derived ingredient that conditions skin, relieves roughness, and gives extra shine. Leaves a water-resistant film on the skin to prevent water loss, giving long-lasting moisturization. INCI: Ricinus communis (castor) seed oil, Hydrogenated castor oil, Copernicia cerifera (carnauba) wax Suggested use level: 1 - 20%; add in the oil phase. Incorporate at temperatures below 85°C. Product is oil soluble, pH range is not applicable. This product is gluten-free, non-GMO, and Ecocert/Cosmos approved.

TRI-K Industries, Inc. CollaPlant Z NPNF® is a vegan, sustainable, and guilt-free alternative to animal collagen. This product was created to have a similar Amino Acid composition when compared to collagen. Just like animal-derived collagen, this will improve skin moisturization to rejuvenate skin and can act as a film-former to protect the skin. INCI: Hydrolyzed Soy Protein, Rice Amino Acids, Hydrolyzed Adansonia Digitata Seed Extract, L-Proline Suggested use level: 1 - 5%; add in the water or cool-down phase, when less than 40°C. For a formulation, the ideal pH range is 4.0 - 6.0. This product is gluten-free and non-GMO.

Fision® Instant Lift - Fast-acting, on-demand anti-aging. Uniform film provides even coverage throughout the skin. Instantly improves skin firmness, reduces the appearance of wrinkles, and smooths skin. It gives your skin instagratification for younger-looking skin. INCI: Water, Hydrolyzed Soy Protein, Acacia Senegal Gum, Xanthan Gum Suggested use level: 3 - 5%; add in the water or cool down phase. Incorporate at temperatures below 40°C. For a formulation, the ideal pH range is 4.5 - 7.0. This product is gluten-free, non-GMO, and Ecocert/Cosmos approved. Alternative Fision® SoyLift and Fision® SkinLift. These are no longer being promoted (slightly different INCI). Sold to existing customers only.

NaturePep® Ganoderma reduces crow’s feet wrinkles and roughness for smoother-looking skin. Repairs dermal degradation and prevents skin’s oxidative & cellular damage caused by aging, UV, environmental stress, and pollutants. Decreases melanin concentration on dark spots for an even skin complexion. INCI: Hydrolyzed Ganoderma Lucidum (Mushroom) Extract Suggested use level: 1 - 5%; add in the water or cool-down phase, when less than 40°C. For a formulation, the ideal pH range is 4.0 - 7.0. This product is gluten-free and non-GMO.

Cogesome® RL (R10115) is a novel and proprietary pro-liposome formulation that encapsulates retinol (vitamin A) for superior penetration into the skin, improved stability, and optimal miscibility in aqueous systems. The power of retinol is undisputed, accelerating epidermal renewal and enhancing collagen and hyaluronic acid production to reduce the appearance of fine lines, wrinkles, and other signs of aging and improve the skin’s overall appearance. Properly managed retinol is one of the skin’s best supporters, contributing to a healthy glow and youthful appearance.Ex vivo data demonstrate how Cogesome® RL rapidly penetrates the skin, enhancing the penetration and delivery of retinol from the skin’s surface deep into the skin to maximize efficacy. Cogesome® RL significantly reduces biofilm-forming skin resident Cutibacterium acnes, a microbial culprit of blemish flare-ups and skin inflammation. Cogesome® RL is well suited for applications in anti-aging, anti-wrinkle, and anti-blemish formulas, skin exfoliating and resurfacing products, and regimens targeting sun damage and hyperpigmentation.

DermalRx® HydroSeal (R10067) is a yeast-derived oligopeptide that fortifies the skin barrier functions to restore moisture retention. Clinical testing demonstrates that DermalRx® HydroSeal has impressive moisturizing and anti-wrinkle effects in four weeks. Ideal for applications in anti-aging, anti-wrinkle, moisturization, and skin repair products, DermalRx® HydroSeal rebuilds cell-to-cell junctions for a more compact and less permeable stratum corneum, reducing transepidermal water loss (TEWL) and improving skin hydration. DermalRx® HydroSeal is produced using biofermentation with a proprietary Saccharomyces cerevisiae strain to improve the integrity of the skin barrier for skin moisturization and protection from excessive water loss.

DermalRx® CKW (R10091) is a plant-derived combinatorial curcuminoid extract that potently and dose-dependently modulates excess sebum production by inhibiting type I and type II 5α-reductase. Clinical evaluation showed significant reductions in sebum production and a visible decrease in facial sheen. DermalRx® CKW is ideal for sebum-regulating products for skin and hair applications, as well as anti-blemish and pore-minimizing formulations.

Pleiotanicals® Volpura® EP (R10098) is an Echinacea purpurea extract to address the signs of aging by supporting the skin’s natural plumping processes. Volpura® EP activates adipogenesis (fat production) within the skin to combat the appearance of wrinkles and sagging from deep within the tissue. Volpura® EP restores fuller, youthful-looking skin by activating an adipogenic modulator that increases the number and size of fat-producing cells. Clinical studies demonstrate that Volpura® EP improves skin mechanical properties with volumizing, anti-wrinkle activity reported after use on the face and hands for 12 weeks. Volpura® EP is recommended for anti-wrinkle, anti-aging, firming, plumping, topical contouring, and volumizing products, as well as regimens to address age-related lipoatrophic disorders.

DermalRx® LuShield™ (R10056) is a proprietary extract of the fragrant flowering Osmanthus fragrans shrub that delivers anti-aging effects through senolytic, antioxidant, anti-inflammatory, and protective activities. DermalRx® LuShield™ addresses cellular senescence due to environmental and dietary stressors while also protecting collagen and the extracellular matrix (ECM, the structural foundation of the skin) from the damaging effects of advanced glycation end-products (AGEs), UV radiation, free radicals, and pollution (PM2.5). DermalRx® LuShield™ protects the skin to facilitate the natural repair, rebuilding, and restructuring of skin and skin matrices for a healthy and youthful appearance.  

Pleiotanicals® Holy Basil OSE (R10104) is a proprietary extract of Ocimum sanctum (a plant used in Ayurvedic medicine) for pollution protection and aging prevention in the skin. Holy Basil OSE contains key active molecules, including polyphenols and pentacyclic triterpenoids, that protect against environmental pollution with anti-aging benefits. Holy Basil OSE is ideal for anti-aging, anti-wrinkle, de-stressing, and pollution/UV protection regimens, as well as soothing, calming products for sensitive skin.   Holy Basil OSE reduces a suite of inflammatory mediators in the skin typically induced by exposure to airborne particular matter (PM2.5). Holy Basil OSE protects the extracellular matrix (ECM, the structural foundation of the skin) against damaging oxidative, proteolytic, and inflammatory stress while also modulating collagen and other genes fundamental for ECM structure and integrity.

DermalRx® SRC-R (R10099) is a yeast-derived oligopeptide that promotes skin renewal by stimulating natural exfoliation via gentle and selective desquamation. Clinical testing demonstrates that DermalRx® SRC-R enhances exfoliation to reduce skin roughness and improve the appearance of wrinkles in four weeks. DermalRx® SRC-R gently loosens coarse keratinized cells at the surface, delivering results for applications in anti-aging, anti-wrinkle, anti-blemish, skin brightening, and exfoliation products. DermalRx® SRC-R is clinically demonstrated to restore skin texture and radiance with documented improvements in the appearance of hyperpigmentation, wrinkles, and other signs of aging. DermalRx® SRC-R is a selective exfoliant for safe, effective skin renewal.

DermalRx® SRC (R10001) is a yeast-derived oligopeptide that promotes skin renewal by stimulating natural exfoliation via gentle and selective desquamation. Clinical testing demonstrates that DermalRx® SRC enhances exfoliation to reduce skin roughness and improve the appearance of wrinkles in four weeks. DermalRx® SRC gently loosens coarse keratinized cells at the surface, delivering results for applications in anti-aging, anti-wrinkle, anti-blemish, skin brightening, and exfoliation products. DermalRx® SRC is clinically demonstrated to restore skin texture and radiance with documented improvements in the appearance of hyperpigmentation, wrinkles, and other signs of aging. DermalRx® SRC is a selective exfoliant for safe, effective skin renewal.

Tellirictin® (R10047) is a proprietary clove flower extract containing natural gallate-based pleiotropic compounds (tellimagrandin I and casuarictin) for multi-functional anti-aging performance. Tellirictin® addresses the many signs of aging by delivering brightening, anti-wrinkle, and moisturizing activities, while also protecting the skin from oxidative, inflammatory, proteolytic, and environmental stresses. Applications of Tellirictin® include anti-aging, anti-wrinkle, and skin-brightening regimens, soothing and calming products for sensitive skin, and pre- and post-sun care.   Tellirictin® prevents excessive melanin production to combat hyperpigmentation by inhibiting tyrosinase activity as efficiently as beta-arbutin. Tellirictin® protects collagen and other components of the extracellular matrix (ECM, the structural foundation of the skin) from damaging enzymes (MMPs and elastases) associated with environmental stressors such as environmental pollution and UV (sun) exposure. Tellirictin® modulates microRNAs involved in the beneficial regulation of DNA repair, barrier protection, and anti-inflammatory pathways. 

DermalRx® KBGA (R10017) is a proprietary blue-green algal extract with a unique combination of naturally-occurring repair active components for skin and hair moisturization and nourishment. Derived from Aphanizomenon flos-aquae (AFA), DermalRx® KBGA is rich in essential amino acids and fatty acids, proteins, antioxidants, and a full spectrum of minerals.Backed with comprehensive efficacy assays, DermalRx® KBGA increases the skin’s ability to maintain moisture at the skin barrier while protecting collagen and other extracellular matrix components (ECM, the structural foundation of the skin) from oxidative and proteolytic stress. With optimized bioactivity and bioavailability, DermalRx® KBGA addresses dry and damaged skin with applications in anti-aging and anti-wrinkle products, and nourishing, moisturizing skin and hair formulations. 

Pleiotanicals® Ellagicin®(R10068) is a botanically derived active ingredient containing proprietary acai and pomegranate “superfruit” extracts for antioxidant and anti-aging benefits. Ellagicin® is rich in ellagic acid, anthocyanins, and other natural antioxidants that provide protection from oxidative and proteolytic stress. Ellagicin® protects collagen and other components of the extracellular matrix (ECM, the structural foundation of the skin) from damaging enzymes associated with environmental stressors such as environmental pollution and UV (sun) exposure. Applications of Ellagicin® include anti-aging and anti-wrinkle regimens, soothing and calming products for sensitive skin, and pre- and post-sun care.

DermalRx® Acetygen® (R10117) is a botanical active ingredient featuring Agrimonia eupatoria and Ampelopsis grossedentata extract with potent phytochemicals (including dihydromyricetin, myricetin, and other bioactive flavonoids). DermalRx® Acetygen® is a potent senolytic and broad-spectrum epigenetic modulator for applications in skin health and wellness, such as anti-aging products targeting oxidative, environmental, and inflammatory damage. DermalRx® Acetygen® enhances natural skin repair mechanisms to help eliminate dysfunctional senescent cells that contribute to signs of tissue aging. By regulating the histone deacetylase (HAT/HDAC) “switch”, DermalRx® Acetygen® epigenetically restores gene expression to levels found in younger skin for a renewed extracellular matrix (ECM). DermalRx® Acetygen® protects the skin from oxidative stress and inflammatory damage while rejuvenating the tissue for a youthful, healthy appearance. 

Pleiotanicals® Holy Basil OSP (R10110) is a proprietary extract of Ocimum sanctum (a plant used in Ayurvedic medicine) for pollution protection and aging prevention in the skin. Holy Basil OSP contains key active molecules, including polyphenols and pentacyclic triterpenoids, that protect against environmental pollution with anti-aging benefits. Holy Basil OSP is ideal for anti-aging, anti-wrinkle, de-stressing, and pollution/UV protection regimens, as well as soothing, calming products for sensitive skin.   Holy Basil OSP reduces a suite of inflammatory mediators in the skin typically induced by exposure to airborne particular matter (PM2.5). Holy Basil OSP protects the extracellular matrix (ECM, the structural foundation of the skin) against damaging oxidative, proteolytic, and inflammatory stress while also modulating collagen and other genes fundamental for ECM structure and integrity.

DermalRx® FSE (R10111) is a marine bioferment produced from Sargassum vulgare for DNA protection and repair in sun-exposed skin. Rich in bioactive phlorotannins, DermalRx® FSE stimulates the skin’s natural DNA repair process through nucleotide excision repair (NER). Ex vivo studies demonstrate DermalRx® FSE’s DNA protective and reparative effects after UV exposure. DermalRx® FSE also provides strong anti-pollution activity, protecting the skin from damaging oxidation and inflammation. DermalRx® FSE is ideal for anti-aging, de-stressing, soothing and calming, and pre- and post-sun care products.

Pleiotanicals® Scavenox® GTE (R10025) is a highly stable green tea extract with epigallocatechin gallate (EGCG) for long-term antioxidant, anti-inflammatory, and skin-brightening activity. Applications for Scavenox® GTE include anti-aging and anti-blemish regimens, skin-brightening and skin tone-balancing systems, and soothing and calming products for sensitive skin.   Scavenox® GTE protects the skin from oxidative stress with the demonstrated ability to prevent UV-induced lipid peroxidation and scavenging of singlet oxygen. Scavenox® GTE also inhibits inflammatory and proteolytic (MMPs and elastase) damage for protection against UV radiation, pollution, and other environmental stressors. These activities offer skin protection and renewal by preserving collagen and other components of the extracellular matrix (ECM, the structural foundation of the skin). Scavenox® GTE prevents excessive melanin production to combat hyperpigmentation by inhibiting tyrosinase activity.

Pleiotanicals® Scavenox® HH (R10109) is a highly stable green tea extract with epigallocatechin gallate (EGCG) for long-term antioxidant, anti-inflammatory, and skin-brightening activity. Applications for Scavenox® HH include anti-aging and anti-blemish regimens, skin-brightening and skin tone-balancing systems, and soothing and calming products for sensitive skin. Scavenox® HH protects the skin from oxidative stress with the demonstrated ability to prevent UV-induced lipid peroxidation and scavenging of singlet oxygen. Scavenox® HH also inhibits inflammatory and proteolytic (MMPs and elastase) damage for protection against UV radiation, pollution, and other environmental stressors. These activities offer skin protection and renewal by preserving collagen and other components of the extracellular matrix (ECM, the structural foundation of the skin). Scavenox® HH prevents excessive melanin production to combat hyperpigmentation by inhibiting tyrosinase activity.

Ash Ingredients Trehalose Dihydrate is a natural disaccharide that acts as a moisturizer and antioxidant. This trehalose is derived from a sustainable agroforestry system where we begin with corn starch from non-GMO corn. Functions: Moisturizer: As a sugar, trehalose acts as a natural moisturizer. Antioxidant: Trehalose demonstrates signs of neutralizing free radicals. Protection: A crystalline envelope is created when in contact with water, offering cell membrane protection.

Fision® EcoSil is a great alternative to silicone for hair and skin care. This naturally derived ingredient gives a soft, light, and dry feel. It will create an even, protective film. This product is an odorless & colorless liquid. INCI: Hydrogenated Ethylhexyl Olivate, Hydrogenated Olive Oil Unsaponifiables Generally Suggested use level: 1 - 25%; add in the oil phase. Incorporate at temperatures below 75°C. Hair Care: Shampoo & shower gels: 0.5 to 3%, introduce it to the surfactant system before the addition of water. Emulsion: 0.5 to 15%. Oils: max. 25%. Product is oil soluble, pH range is not applicable. This product is gluten-free, non-GMO, and Ecocert/Cosmos approved.

Fision® PentaFruit V effectively rejuvenates the skin to make it feel younger, healthier, and smother by stimulating cell renewal. It is preservative free and easy to formulate with. Works well in toners, peels, masks, and serums. Gives skin a refreshing morning glow. INCI: Water, Lactic Acid, Glycolic Acid, Vaccinium Myrtillus Fruit Extract, Saccharum Officinarum (Sugarcane) Extract, Citric Acid, Citrus Aurantium Dulcis (Orange) Fruit Extract, Citrus Limon (Lemon) Fruit Extract, Acer Saccharum (Sugar Maple) Extract, Tartaric Acid, Malic Acid Suggested use level: 1 - 4%; add in the water or cool down phase. Incorporate at temperatures below 40°C. For a formulation, the ideal pH range is 4.0 - 6.0. This product is gluten-free and non-GMO.

Robustyl® is a phyto-active ingredient obtained by controlled extraction using butylene glycol and water from the seeds of green coffee (Coffea canephora synonym Robusta). The product appears as a translucent solution with possibly a slight precipitate and has a characteristic odor. It is soluble in water and ethanol (20% v/v) and is mainly used in cosmetic products.