Products in Excipients: Direct Compression

L-HPC (low-substituted hydroxypropyl cellulose NF, JP, EP) This dual functioning excipient acts as both a disintegrant and binder. It is not the same as HPC. L-HPC is insoluble in water. It is an effective disintegrant due to its swelling action in water. Because is has good compressibility, it functions as a dry binder.L-HPC benefits are:Enhanced stability because it is non-ionic and has low water activityIt is peroxide free and provides excellent compatibility for oxygen sensitive APIsImproved disintegrationA variety of grades are available depending on the application. L-HPC LH-32 is suitable for wet granulation, pellet extrusion and layering.

SmartEx® is a co-processed excipient which consists of L-HPC, D-mannitol and fully hydrolyzed polyvinyl alcohol (PVA) and it specially designed for orally disintegration tablets (ODTs) and also immediate release tablet formulation by direct compression. All the excipients are widely used in pharmaceutical industry. One of the main advantage over other co-processed excipients is that SmartEx® contains L-HPC and therefore gives excellent stability.

TYLOPUR® 65SH-4000is a versatile hypromellose, compliant with USP, JP, EP. The low viscosity grades are especially suitable for the design of film-coated tablet formulations.TYLOPUR® 65SH-4000 is effective as a binder, since it does not interact with drugs. It has superior stability, a non-ionic character and is widely used as a binder for granulation. Due to its plant derived nature and excellent moisture stability, TYLOPUR® replaces gelatin in hard capsule manufacturing.

TYLOPUR® 65SH-1500 is a versatile hypromellose, compliant with USP, JP, EP. The low viscosity grades are especially suitable for the design of film-coated tablet formulations.TYLOPUR® 65SH-1500 is effective as a binder, since it does not interact with drugs. It has superior stability, a non-ionic character and is widely used as a binder for granulation. Due to its plant derived nature and excellent moisture stability, TYLOPUR® replaces gelatin in hard capsule manufacturing.

TYLOPUR® is a versatile hypromellose, compliant with USP, JP, EP. TYLOPUR 60SH-4000 provides a genuine consistency in Sustained release (matrix tablets). It also can be used as thickener in aqeous solution .It is also a good suspending agent in colloidal solution.

L-HPC (low-substituted hydroxypropyl cellulose NF, JP, EP) This dual functioning excipient acts as both a disintegrant and binder. It is not the same as HPC. L-HPC is insoluble in water. It is an effective disintegrant due to its swelling action in water. Because is has good compressibility, it functions as a dry binder.NBD Grades:Better flowability because of the non-fibrous particle shapeBetter compressibilityBetter tasteEnhanced stability because it is non-ionic and has low water activityIt is peroxide free and provides excellent compatibility for oxygen sensitive APIsA variety of grades are available depending on the application.L-HPC NBD-021 is suitable for direct compression and wet granulation.

L-HPC (low-substituted hydroxypropyl cellulose NF, JP, EP) This dual functioning excipient acts as both a disintegrant and binder. It is not the same as HPC. L-HPC is insoluble in water. It is an effective disintegrant due to its swelling action in water. Because is has good compressibility, it functions as a dry binder.L-HPC benefits are:Enhanced stability because it is non-ionic and has low water activityIt is peroxide free and provides excellent compatibility for oxygen sensitive APIsImproved disintegrationA variety of grades are available depending on the application.L-HPC LH-B1 is suitable for fluidized-bed granulation, direct compression for high-load formulations and as a dispersion aid for capsules.

L-HPC (low-substituted hydroxypropyl cellulose NF, JP, EP) This dual functioning excipient acts as both a disintegrant and binder. It is not the same as HPC. L-HPC is insoluble in water. It is an effective disintegrant due to its swelling action in water. Because is has good compressibility, it functions as a dry binder.L-HPC benefits are:Enhanced stability because it is non-ionic and has low water activityIt is peroxide free and provides excellent compatibility for oxygen sensitive APIsImproved disintegrationA variety of grades are available depending on the application.L-HPC LH-21 is suitable for wet granulation.

L-HPC (low-substituted hydroxypropyl cellulose NF, JP, EP) This dual functioning excipient acts as both a disintegrant and binder. It is not the same as HPC. L-HPC is insoluble in water. It is an effective disintegrant due to its swelling action in water. Because is has good compressibility, it functions as a dry binder.L-HPC benefits are:Enhanced stability because it is non-ionic and has low water activityIt is peroxide free and provides excellent compatibility for oxygen sensitive APIsImproved disintegrationA variety of grades are available depending on the application. L-HPC LH-31 is suitable for wet granulation, pellet extrusion and layering.

TYLOPUR® 90SH-4 is a versatile hypromellose, compliant with USP, JP, EP. The low viscosity grades are especially suitable for the design of film-coated tablet formulations.TYLOPUR® 90SH-4 is effective as a binder, since it does not interact with drugs. It has superior stability, a non-ionic character and is widely used as a binder for granulation. Due to its plant derived nature and excellent moisture stability, TYLOPUR® replaces gelatin in hard capsule manufacturing.

TYLOPUR® 603 is a versatile hypromellose, compliant with USP, JP, EP. It is a film coating material that provides an excellent finish. It is a effective binder, it does not interact with drugs. It also enhances the solubility of poorly solule APIs.

CompactCel® FLO is a flow agent for loosening powder mixtures and improving flowability. The ready-touse powder compound replaces synthetic additives such as silicon dioxide. It prevents bridge formation during flow from hopper and provides a clean funnel flow of the powder mass to be processed during both tableting and capsule filling.

Based on fine selected natural ingredients, this dry binder premix for direct compression supports clean label strategies for nutritional products. By using this premix compound, typical tableting ingredients like Hydroxypropyl cellulose or Plyvinylpyrrolidone can be replaced in the core formulation.

BIOGRUND’s one-step tabletting agent CompactCel® SIL provides an easy to use, granulated and homogeneous compound of Silica and PVP/ NaCMC or HPC/NaCMC, which acts as a perfect dry binder granulate.

BIOGRUND’s one-step binding agent CompactCel® provides an easy to use, granulated and homogeneous compound of PVP/NaCMC or HPC/ NaCMC, which acts as a perfect dry binder.

BIOGRUND’s tableting agent CompactCel® TC provides an easy to use and homogeneous compound of several sugar alcohols and cellulose fibers, which acts as a perfect taste masking dry binder.

Based on fine selected natural ingredients, this dry binder premix for direct compression supports clean label strategies for nutritional products. By using this premix compound, typical tableting excipients like Hydroxypropyl cellulose or Polyvinylpyrrolidone can be replaced in the core formulation.

BIOGRUND’s one-step lubricant premix CompactCel® LUB enhances the flow of tablet production by reducing friction between particles at the interface between the tablet and the die wall. The lubricant reduces wear on punches and prevents sticking to punch faces. Furthermore CompactCel® LUB is also suitable for filling and closing hard gelatin capsules to achieve a smooth filling process.

The ingredient premix CompactCel® MAB provides an oil and moisture holding capacity and prevents clumping of your powder blend. The homogeneous dry powder product controls humidity related issues in formulas or absorbs oily substances into free flowing powder.

BIOGRUND’s one-step matrix agent CompactCel® SR provides an easy-to-use compound which controls the sustained release of active ingredients. CompactCel® SR forms a gel, through which the active ingredient diffuses. The use of NaCMC accelerates the gel-forming process, so the initial drug release is reduced.

CompactCel® DIS is a natural/organic super-disintegrant which enables a rapid break-up of solid dosage forms when they come into contact with moisture. The super-disintegrant premix is formulated with natrual ingredients which complies with current Clean Label Standards. It provides an alternative to synthetic super-disintegrants, such as crosslinked polymers, crosscarmellose sodium or sodium starch glycolate. CompactCel® DIS helps in the fast breakdown of the solid dosage form so that the active ingredient becomes bioavailable faster and is readily absorbed. It can be also used in the formulation of oral disintegrating tablets (ODT) or chewing tablets.

Sterotex® HM is a fully-hydrogenated, vegetable-oil powder that is widely used as a lubricant in tablet manufacturing in pharmaceutical and food supplement industries. It may be used in compacting and compounding processes in the catalyst, ceramic and powder metallurgy fields. Sterotex® HM is derived from renewable vegetable oils that are fully refined, bleached, and deodorized and is a neutral organic ester (triglyceride) that is low in ash content and is produced according to Kosher requirements. It is manufactured in USA.

Sterotex® K, NF is a powder that is widely used as a lubricant in tablet manufacturing in pharmaceutical industries. It may be used in compacting and compounding processes in the catalyst, ceramic and powder metallurgy fields. Sterotex® K, NF is derived from renewable vegetable oils that are fully refined, bleached, and deodorized and is a neutral organic ester (triglyceride) that is low in ash content. It is manufactured in USA.

Sterotex® NF is a powder that is widely used as a lubricant in tablet manufacturing in pharmaceutical and food supplement industries. It may be used in compacting and compounding processes in the catalyst, ceramic and powder metallurgy fields. Sterotex® NF is derived from fully refined, bleached and deodorized renewable vegetable oil, and is a neutral organic ester (triglyceride) that is low in ash content. Sterotex® NF is produced according to Kosher requirements. It is manufactured in USA.

Capmul® GDB EP/NF is a mixture of diglycerides, mainly glyceryl dibehenate, together with variable quantities of monoglycerides and triglycerides. It is obtained by the esterification of glycerol with behenic acid of vegetable origin. It is manufactured in USA.

Sterotex® P is a spray-chilled powder produced from fractionated, non-hydrogenated, refined palm oil. It is manufactured in USA.

Divi's Nutraceuticals Lutein 10% DC/AF is a directly compressible and animal-free beadlet.

EXCIPRESS™ SD2L is a spray dried lactose typically used for direct compression. It is manufactured under GMP standards and conforms to Ph.Eur, USP NF and JP lactose monohydrate monographs. Spray dried lactose consists of fine primary lactose particles bound in a matrix of amorphous lactose, It combines high compaction properties of fine lactose crystals and amorphous lactose & very good flowability of spherical particles.

Compression base ready for use, adequately balanced in qualitative, quantitative and rheological properties, which makes it possible to obtain tablets by direct compression.

Microcrystalline Cellulose is purified, partially depolymerized cellulose prepared by treating alpha cellulose, obtained as a pulp from fibrous plant material, with mineral acids

Off white free flowing granules.

Granulated Calcium Citrate Malate for direct compression.

Off white free flowing granules.

Granulated Calcium Citrate Malate for direct compression.

Granulated mineral calcium carbonate for direct compression.

Microcrystalline Cellulose is purified, partially depolymerized cellulose prepared by treating alpha cellulose, obtained as a pulp from fibrous plant material, with mineral acids