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Amicogen AMK518

Amicogen AMK518 produces cefradine from 7-ADCA(7-amino-3-deacetoxy-cephalosporanic acid) and DHME(D-dihydrophenylglycine methyl ester).

Functions: Enzyme

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    Identification & Functionality

    Chemical Family
    Pharma & Nutraceuticals Functions

    Features & Benefits

    Characteristics
    • High synthesis activity of cefradine
    • Low degradation activity of cefradine and DHME
    • Fast enzymatic reaction (reaction completed in 90 mins
    • High yield synthesis of cefradine (>95%)​

    Applications & Uses

    Application
    • Cefradine production from 7-ACDA and DHME

    Properties

    Solvent
    Water
    Typical Properties
    ValueUnitsTest Method / Conditions
    pH8.0-8.3--
    Temperature10°C-
    7ADCA : PGM1:1.05-1.10--
    Enzyme Amount7U/ml-
    Activityᵃ100U/g-
    Size of Immobilization (min. 98%)300-500µm-
    Water Content max. 60%-
    Enzyme Assay

    aOne unit (U) represents the amount of enzyme required for producing 1㎛ol cefradine per min in 0.1M K-phosphate buffer containing 20mM 7-ADCA(7-amino-3-deacetoxy-cephalosporanic acid) and 20mM DHME(D-dihydrophenylglycine methyl ester), pH 7.5 at 28℃.

    Storage & Handling

    Storage
    • 4 - 10°C