Knowde Enhanced TDS
Identification & Functionality
- Carrier
- Ingredient Origin
- Cosmetic Ingredients Functions
- EINECS No.
- 231-791-2, 246-376-1, 215-181-3, 201-069-1, 200-075-1, 200-333-3, 200-334-9, 200-675-3
- Technologies
- Product Families
- Origin
- Fructan - Bacterial
- Aqua - Mineral
- Glucose - Vegetable
- Fructose - Vegetable
- Sucrose - Vegetable
- Sodium Citrate - Vegetable
- Citric Acid - Vegetable
- Potassium Hydroxide - Synthetic
- Potassium Sorbate - Synthetic
Features & Benefits
- Benefit Claims
- Labeling Claims
- Product Highlights
Skin aging is characterized by a disruption of Stratum corneum and barrier integrity, a slow down of keratinocyte renewal and a decrease in biomechanical filament synthesis (collagen for example). It induces a reduction in skin water retention leading to a loss of elasticity, firmness and thickness.
Thanks to the biological expertise of Greentech Group combined to the biotransformation of Gan Shmuel Group, PoLevan S was developped, a rejuvenating active ingredient.- Action
- Enhances epidermal rejuvenation
- Hyaluronic acid like
- Maintains moisturization
- Reduces wrinkles
- Cosmetic Benefits
PoLevan S is a regenerative and anti-aging active that enables to limit premature signs of
age. This daily skin care visibly attenuates wrinkles. It participates in skin strengthening with its hydrating and tightening power to restore firmness, elasticity and radiance to the skin.
Applications & Uses
- Markets
- Applications
- Skin Care Applications
- Sun Care Applications
- Cosmetic Use
- Moisturizing care
- Softening products
- After-sun care
- Anti-age range
- Formulations
- Concentration for use: 1 to 2 %
- pH for use: 4.0 – 8.0
- Caution for use: Add to emulsions, at the end of the preparation process, either cold or at 35-40°C, during cooling.
Properties
- Physical Form
- Odor
- Characteristic
- Appearance
- Opalescent viscous liquid
- Soluble in
- Water
- Typical Properties
- Physico-Chemical Properties
- Quantifications
- Microbiological Values
| Value | Units | Test Method / Conditions | |
| Natural Content | 12.4 | % | - |
| Natural Origin Content | 99.4 | % | - |
| Value | Units | Test Method / Conditions | |
| Dry Matter | min. 50.0 | % | GT006 |
| pH Value (Direct) | 5.0 - 6.0 | - | GT005 |
| Value | Units | Test Method / Conditions | |
| Levan (exp: fructan) | min. 20.0 | % m/m | GT0115 |
| Total Monosaccharids | min. 40.0 | % m/m | GT045 |
| Value | Units | Test Method / Conditions | |
| Detection of Enterobacteria | Absence | - | ISO 18415 |
| Enumeration of Mesophilic Aerobic Bacteria | max. 100 | ufc/mL - cfu/mL | ISO 21149 |
| Enumeration of Yeasts and Molds | max. 100 | ufc/mL - cfu/mL | ISO 16212 |
Regulatory & Compliance
- Certifications & Compliance
- REACH Status
INCI Concentration REACH Status Fructan 20 – 40 % Exempt: < 1 ton/year (dry matter) Aqua 12.4 – 55.4 % Water exempted annex IV Glucose 15 – 25 % Exempt: < 1 ton/year (dry matter) Fructose 0 – 10 % Exempt: < 1 ton/year (dry matter) Sucrose 0 – 10 % Exempt: < 1 ton/year (dry matter) Sodium Citrate ≤ 1 % Trisodium citrate
registered n°01-2119457027-40Citric Acid ≤ 1 % Citric Acid registered
n°01-2119457026-42Potassium Hydroxide ≤ 0.5 % Potassium hydroxide
registered n°01-2119487136-33Potassium Sorbate ≤ 0.1 % Potassium Sorbate
registered n°01-2119950315-41
Technical Details & Test Data
- Proven Efficacy
- Procollagen I
Collagen is an important skin component, acting on hydration and biomechanical properties.
On skin explant obtained from a healthy patient. Treatment with or without PoLevan S at
different concentrations by topical application. After 48h of incubation, the turnover
rate was determined by ELISA assay.
*p<0.05 vs controlA significant increase in procollagen I was observed. PoLevan S was as effective as TGF-β, a growth factor regulating the architecture and the degradation of extracellular matrix.
- Cellular proliferation
On skin explant obtained from a healthy patient. Treatment with or without PoLevan S at
different concentrations by topical application. After 48h of incubation, the turnover
rate was determined by BrdU assay.PoLevan S acts on cellular proliferation. The alteration due to aging may be less visible.
Polevan S accelerates epidermis proliferation rate thus acting to promote skin rejuvenation, an important feature of skin vitality and firmness.
- Water balance
Taurine plays a major role in osmoregulation and as a membrane stabilizer
On human normal keratinocytes. Cells incubated during 24 hours in absence (control) or in presence of PoLevan S. Quantification in cell lysate using an ELISA assay.
*p<0.05 vs controlPoLevan S significantly increases content in taurine transporter.
Polevan S limits dehydration and preserves membrane integrity.
- Clinical Study
- Evaluation of moisturization (Corneometer® measurements), immediate effect
Double blind test on 18 volunteers (22 to 50 years old). A unique application in the morning on forearms. Comparison of PoLevan S (1.6%) and hyaluronic acid low molecular weight (HA 0.2%).
Polevan S maintains moisturization, similarly to hyaluronic acid.- Effect on wrinkles
Double blind test on 11 women (40 to 70 years old). Twice daily application during 4 weeks. Comparison of PoLevan S 1.6% to hyaluronic acid (HA) 0.2%.
Wrinkle assessment (0-10 scale) by a dermatologist
* p<0.05 vs D0
Wrinkle improvement (0-10 scale) evaluated by volunteers
HA (0.2%) 4.1 PoLevan S (1.6%) 4.6 Polevan S shows an anti-wrinkle activity similarly to hyaluronic acid.
- Self-assessement
Polevan S has same effects than hyaluronic acid according to the volunteers.- Effect on skin pH
SLES vs SLES + PoLevan S 1.6% vs PoLevan S 1.6%. Acidic control used to validate the protocol (data not shown). Application on the arm of 14 volunteers. pH was measured at T0, T20 min, T2H and T6h.
Polevan S limits detergent-induced ph disturbance
Storage & Handling
- Shelf Life
- 12 months
- Storage
15 / +25°C
Keep in the original packaging, without opening, in the recommended storage conditions.