Knowde Enhanced TDS
Identification & Functionality
- Chemical Name
- Ingredient Origin
- Pharma & Nutraceuticals Functions
- Product Families
- Plant Source
Twig and Leaf
- Botanical Origin
Taxus baccata L.
Features & Benefits
- Benefit Claims (Health)
- Labeling Claims
- Product Overview
- 10-Deacetylbaccatins are natural molecules isolated by a multistep biosynthetic pathway from the yew tree, acting as precursors to the anticancer drug docetaxel. The key reaction is the acetylation of 10-deacetylbaccatin-III (10-DAB) to obtain baccatin-III, an assumed precursor of docetaxel.
- The breakthrough arrived during the 80s, when a group of researchers guided by Pierre Potier - at the forefront of the French school of natural-products chemistry - identified the 10-Deacetylbaccatin III, isolated from Taxus baccata, as a readily accessible starting material for the semisynthesis of anticancer taxanes.
- Already in that time, the taxanes attracted attention because of their promising clinical activities as anticancer, altogether with some worries about their limited availability; this generated a wide number of studies aimed to solve this issue.
- Finally, the possibility to obtain large quantities of taxanes with a purity grade available for clinical scopes by a biosynthetic pathway, standardized and controlled, was welcomed with lot of enthusiasm.
- Health Benefits
Chemical intermediate
Applications & Uses
- Markets
Properties
- Typical Properties
| Value | Units | Test Method / Conditions | |
| Assay | min. 96.0 | % | HPLC Method |