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COMPRECEL® SMCC 50

1 of 13 products in this brand
Comprecel® SMCC 50 is an integrated particle combined with 98% Microcrystalline Cellulose and 2% colloidal silicon dioxide. By co-processing technology, colloidal silicon dioxide is uniformly distributed on surface of MCC particle. Comprecel® SMCC is a highly functional ingredient that solve complex formulation problems and simplify manufacturing process.

Chemical Name: Cellulose, Microcrystalline

CAS Number: 9004-34-6

Manufacturing Technology: Direct Compression, Dry Granulation, Wet Granulation

Functions: Binder, Disintegrant

Synonyms: Crystalline cellulose, Micro Fibril Cellulose, Pyrocellulose

    Knowde Enhanced TDS

    Identification & Functionality

    Pharma & Nutraceuticals Functions
    CAS No.
    9004-34-6
    EC No.
    232-674-9

    Features & Benefits

    Benefits
    • Improved Compactibility
    • Enhanced Flow
    • Less sensitive for lubrication
    • Dust-reduced Handling in production

    Applications & Uses

    Dosage Form

    Properties

    Physical Form
    Typical Properties
    ValueUnitsTest Method / Conditions
    LODmax. 7.0%
    Bulk Density 0.25 - 0.37g/ml-
    Particle Size Distribution (laser test method, D10)15 - 30 μm-
    Particle Size Distribution (laser test method, D50)45 - 80μm-
    Particle Size Distribution (laser test method, D90)100 - 180μm-

    Technical Details & Test Data

    Particle Size

    Effect of particle Size on Flowability: 
    Coarser particle size is associated with better flowability. Variation in powder flow during manufacturing affect the quality of the product in terms of its weight variation and content uniformity. Flow also affects manufacturing efficiency (Blending time and tableting speed).

    COMPRECEL® SMCC 50 - Particle Size

    Effect of Particle Size on Tablet Compactability: 
    The curves in the plot of tablet hardness versus compression force represent different particle size types of Comprecel. The finer particle size type gives increasingly harder tablets.

    COMPRECEL® SMCC 50 - Particle Size - 1