Knowde Enhanced TDS
Identification & Functionality
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Features & Benefits
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The aging of skin, as visualized at the exposed areas of skin, reflects dramatic alterations in the structure and function of the extracellular matrix (structural support for cells) of connective tissues. Among them, the elastic fiber network, which is responsible for the elasticity and resilience of normal skin, undergoes degradative changes leading to loss of functional elastic fibers. Thus wrinkles and sagging skin. A strategy to counteract these degenerative changes entails topical application of copper-zinc-malonate, a compound that leads to regeneration of the elastic fiber network.
Study have evaluated the effects of a bi-metal, 0.1% copper–zinc malonate-containing cream that has been shown to efface (erase) wrinkles in clinical trials. An effect on elastin biosynthesis (the production of complex molecules within living organisms) or cells and elastic tissue accumulation in skin biopsies was observed in 21 female patients with photoaged facial skin, as measured at baseline and at 6 weeks of treatment. This study suggests that elastin biosynthesis in the skin can be enhanced by a bi-metal, 0.1% copper–zinc containing topical preparation which would then lead to progressive restoration of the elastic fiber network and could explain, at least in part, the clinical improvement noted with this preparation upon 6–8 weeks twice-daily application.
- Job Duties
- Stabilizes skin from degradation.
- Stimulate elastin biosynthesis (new cell growth).
- Positive effect on photoaged facial skin
- Eliminate wrinkles and sagging skin
- Restore elastic fiber network
- Time frame: 6-8 weeks
Applications & Uses
- Markets
- Applications
- Skin Care Applications
Technical Details & Test Data
- Formulating Tips
- Add 0.1% copper–zinc malonate to creams, serum, lotions, moisturizers
- Add to warm water to dissolve.