Knowde Enhanced TDS
Identification & Functionality
- Carrier
- INCI Name
- Ingredient Origin
- Cosmetic Ingredients Functions
- Technologies
- Product Families
Features & Benefits
- Benefit Claims
- Labeling Claims
- Product Highlights
- Minimized inflammation in vitro, even under metabolic stress
- Inhibiting garb-aging and anti-glycation effect
- Calming sensitive skin for a youthful and healthy appearance
Applications & Uses
- Markets
- Applications
- Application Format
- Skin Care Applications
- Use Level
- 2%
Properties
- Solubility
- Appearance
- Light yellow to yellow transparent solution
- Soluble in
- Water
- Typical Properties
| Value | Units | Test Method / Conditions | |
| Natural Origin Content | 100 | % | — |
| Bacillus Ferment Content (in commercial solution) | 0.5 | % | — |
Regulatory & Compliance
- Certifications & Compliance
- Chemical Inventories
Technical Details & Test Data
- Science Behind the Product
Inflammation is a hallmark of sensitive skin, which can be attributed to various factors. External stressors and metabolic stress, arising from an unhealthy diet high in fat and sugars, trigger the release of stressorins by skin cells. These stressorins stimulate the secretion of pro-inflammatory cytokines and amplify the inflammatory response. Metabolic stress, in conjunction with the aging process, also leads to the accumulation of advanced glycation end products (AGEs) and the buildup of cellular waste, also known as garb-aging. Lipofuscin, a major component of this waste, is associated with the formation of dark spots.
Zenerity™ biotech ingredient showed in vitro to counteract skin inflammation and the garb-aging process induced by metabolic stress and aging. When tested in volunteers, it helped soothe sensitive skin, while leaving it looking more luminous, healthier and younger. These positive effects, as well as wellbeing benefits, were observed even when individuals were following an unhealthy diet.
- In Vitro Efficacy
- Minimized skin inflammation and anti-glycation effect in vitro
- Reduced garb-aging in vitro (equivalent to cells behaving younger)
- In Vivo Efficacy
Youthful Looking Sensitive Skin:
35 female and male volunteers of Asian descent with sensitive skin applied a cream with 2% Zenerity™ Biotech Ingredient or a placebo cream, half face and on the forearms, twice a day for 28 days.
Anti-glycation effect:
The accumulation of AGEs on the skin was evaluated through an AGEs reader on the forearm. The yellow color of the skin was evaluated on the cheek through the b* parameter by spectrophotometry.
Results:
- Improved skin redness, hydration, roughness, luminosity and dark spots
- Decreased accumulation of AGEs for a less sallow appearance
- In Vivo Efficacy
Taking Care of Sensitive and Unhealthy Skin:
83 female and male volunteers of Caucasian or Latin American descent, with sensitive skin and with either a healthy or an unhealthy diet, applied a cream with 2% Zenerity™ Biotech Ingredient or a placebo cream on the whole face, twice a day for 28 days.
Immediate redness reduction - Skin redness was evaluated before and after 30 minutes of a single product application by means of image analysis applying a redness filter.
Reduced number of dark spots - The number of dark spots was evaluated through image analysis from cross-polarized images, after applying a specific filter.\
Results:
- Best rejuvenating results for the unhealthy diet group (whose skin is in greater need of care).
- Up to 15.1% skin redness reduction after only 30 min
- More even skin tone