THERACURMIN®

Identification & Functionality

Active Component

Curcumene

Ingredient Name

Turmeric Rhizome Extract

Pharma & Nutraceuticals Functions

Phytochemical

Ingredients

Curcumin Extract

Technologies

Food Ingredients,

Pharmaceuticals & Nutraceuticals

Product Families

Pharmaceuticals & Nutraceuticals — Nutraceuticals & Supplements

Phytochemicals & Plant Extracts

Food Ingredients — Nutrition & Fortification

Phytochemicals

Food Ingredients — Whole Foods, Extracts & Premixes

Plant & Herb Products & Extracts

Chemical Structure

Features & Benefits

Food Ingredients Features

Anti-Cancer Properties,

Anti-Fatigue,

Anti-Inflammatory,

Antioxidant Properties,

Enhance Memory And Mental Clarity,

Excellent Bioavailability,

Healthy Ageing,

Improved Cognitive Function

Turmeric & Curcumin

What is turmeric?

Turmeric is a perennial plant of the ginger family and is widely spread throughout South and Southeast Asian countries. It is commonly used as a spice, flavoring agent, food preservative, and coloring agent, and is known as a key ingredient of curry powder.

What is curcumin?

Curcumin is a polyphenol contained in the rhizome of turmeric and is considered to be a main active ingredient of turmeric. It has a bright yellow color and is used as a natural food dye.
It is also well known for its effect of anti-inflammatory and anti-oxidant amongst medical and health science laboratories all over the world. A great number of researches are being conducted by a variety of medical and science institutes.

Applications & Uses

Markets

Food & Nutrition

Applications

Food & Nutrition — Beverage

Energy Drinks

Food & Nutrition — Food

Confectionery,

Desserts & Fruit Preparations,

Savory & Culinary

Food & Nutrition — Nutrition & Well Being

Functional Foods,

Nutraceuticals & Supplements

Food & Nutrition Applications

Chewing Gum,

Functional Beverages,

Functional Foods,

Jellies,

Noodles & Pasta,

Nutraceuticals

Main evidence for THERACURMIN®

• Anti-oxidant &
• Anti-inflammatory Effect
• Osteoarthritis Effect
• Muscle fatigue Effect
• Dementia Effect
• Liver function Effect
• Cardiovascular Effect
• COPD Effect
• Cancer Treatment

Line Up

A highly absorbent curcumin preparation used as a raw material of functional food.
By crumbling the particles of curcumin and maintaining their particle sizes stably, the particles are absorbed by approximately 27-fold. As it also has water dispersion capability and heat and light resistance characteristics, it is applicable to any forms of products as shown below.

• Hard capsule
• Tablet
• Granules
• Beverage, Liquid
• Gummy, chewable, gum
• Jelly
• Ice lolly, popsicle, sherbet
• Noodles

Properties

Physical Form

Capsules,

Granules,

Solid

Technical Details & Test Data

THERACURMIN® Possesses High Bioavailability

Area Under the Curve(AUC)0-6h values of THERACURMIN^® were 27-fold higher than those of curcumin powder.
AUC0-24 h was found to be 11.0- and 5- fold higher with TEHRACURMIN^® than Company A and Company B, respectively.

Study Protocol

Study design:
Two arms, randomized parallel-group controlled trial

Subjects:
14 healthy subjects (male/female=8/6, age: 44.1±8.5 years old)

Intake:
-THERACURMIN^®：30mg -Ordinary curcumin: 30mg

Area Under the Curve(AUC)0-6h values of THERACURMIN^® were 27-fold higher than those of curcumin powder.

 

Study Protocol

Study design:
Three arms, randomized double-blind 3-way crossover trial

Subjects:
9 healthy subjects (male/female=5/4, age: 24-32)

Intake:
-THERACURMIN^®：180mg
-Company A: 260mg
-Company B: 150mg

AUC0-24 h was found to be 11.0- and 5- fold higher with TEHRACURMIN^® than Company A and Company B, respectively.

Product Highlights

Safety and toxicity data of THERACURMIN®

Toxicity data
Test	Ames test	Chromosome aberration test	Micronucleus assay test	Acute toxicity study (Rats)	Subacute toxicity study (Rats)	Subchronic toxicity study (Rats)
Test detail	Salmonella spp. (4 strains) E.Coli	In vitro shromosome aberration test in Chinese hamster lung cells	Male sprague dewley rats bone merrow micronucles assay	Dose: 1250,2500,5000mg/kg (As curcumin 375,750,1500mg/kg) Once	Dose: 0,625,1250,2500,5000mg/kg (As curcumin 0,187.5,375,750,1500mg/kg) Period： 2 weeks	Dose: 0,1250,2500,5000mg/kg (As curcumin 0,375,750,1500mg/kg) Period： 13 weeks
Result	Negative	Negative	Negative	No toxicological findings observed by oral administration	No toxicological findings observed by oral administration	No toxicological findings observed by oral administration

 

Clinical study in healthy volunteers
Test	4-week clinical study in healthy volunteers at excessive dosage	12-week clinical study in healthy volunteers at standard dosage
Test detail	Tested dosage: 900mg/q.d./p.o. (as curcumin, 5x of standard dosage) Period: 4weeks	Tested dosage: 180mg/q.d./p.o. (as curcumin standard dosage) Period; 12weeks.
Result	THERACURMIN® was proved safe in this study.	THERACURMIN® was proved safe in this study.

• q.d.: Once a day
• p.o.: Oral intake
• ADI: Acceptable Daily Intake
• Standard dosage: 180mg/day (as curcumin)= ADI: 3mg/kg x 60kg (average adult body weight)

Previous clinical study
Study title	Memory and Brain Amyloid and Tau Effects of a Bioavailable Form of Curcumin in Non-Demented Adults: A Double-Blind, Placebo-Controlled 18-Month Trial.	12-week clinical study in healthy volunteers at standard dosage
Test detail	Subject: Non-Demented Adults THERACURMIN® dose: 180mg/day Period: 18 months	Subject: Patients with stage Ⅰ-ⅡCOPD THERACURMIN® dose: 180mg/day Period: 6 months
Result	No serious adverse effects were obsevered in this study	No serious adverse effects were obsevered in this study