Knowde Enhanced TDS
Identification & Functionality
- Carrier
- Ingredient Origin
- Cosmetic Ingredients Functions
- Technologies
Features & Benefits
- Benefit Claims
- Labeling Claims
Applications & Uses
- Markets
- Applications
- Skin Care Applications
- Application pH Range
- 2 - 9
- Use Level
- 0.5 - 2 %
- Application Data
Quora Noni™ Biomics C 02 can be formulated in O/W emulsions, as well as in aqueous gels, masks, solutions and serums. We recommend adding it in the final step of the manufacturing process, preferably under 40°C, i.e., during the cooling phase.
After some time, a precipitate appears. Being the product a suspension of cells in a liquid medium, this is completely normal and can be solved by shaking well before use.
No incompatibilities have been reported: it is compatible with a wide range of thickeners (e.g., from carbomers and polyacrylates to natural thickeners such as cellulose, hectorite, silicates, xanthan gum or other vegetal gums); it is compatible with a wide variety of preservative systems, additives and also with active ingredients commonly used in formulations for acne-prone skin such as zinc, salicylic acid, niacinamide, sulfide, alcohol or menthol. Therefore, the product Quora Noni™ Biomics C 02 can be formulated in a wide range of skin care formulations. The pH of Quora Noni™ Biomics C 02 does not affect the pH or the viscosity of final cosmetic formulations at the recommended use dosage.
A dosage of 0.5 - 2 % of Quora Noni™ Biomics C 02 is recommended in final cosmetic formulations.
Properties
- Appearance
- Yellowish to orange viscous suspension⁽¹⁾⁽²⁾
- Odor
- Characteristic
- Dispersible in
- Water, Ethanol
- Physico-Chemical Properties
- Microbiological Values
- Composition
- Note
⁽¹⁾This is a natural product, so color or transparency may evolve slightly after production without affecting its properties.
⁽²⁾After some time, a precipitate appears. Being the product a suspension of cells in a liquid medium, this is completely normal and can be solved by shaking well before use.
⁽³⁾According to ISO 17516:2014 (and according to USP Chapter 61 or EP Chapter 2.6.12) due to inherent variability of the plate count method results are considered out of limit if > 200 CFU/g. Our specific test report does not obviate the need to test products for the own intentions and purposes of your company.
- Solubility
The product Quora Noni™ Biomics C 02 is dispersible in water and in ethanol.
- Recommended pH Range
A pH range of 2.0 - 9.0 is recommended in final cosmetic formulations containing Quora Noni™ Biomics C 02. Depending on the type of formulation, at a pH lower than 7.5 the product may give a slight pale yellow color to the formulation, and a slight pale purple color at a pH higher than 7.5.
| Value | Units | Test Method / Conditions | |
| pH | 2.0 - 3.5 | - | IOCQ02/001 |
| Density | 1.10 - 1.30 | g/mL | IOCQ1012 |
| Value | Units | Test Method / Conditions | |
| Total Aerobic Microbial Count | max. 100⁽³⁾ | cfu/g | UNE-EN ISO 21149 |
| Yeast and Mold Count | max. 10 | cfu/g | UNE-EN ISO 16212 |
| Escherichia coli | Absence | in 1g | UNE-EN ISO 21150 |
| Staphylococcus aureus | Absence | in 1g | UNE-EN ISO 22718 |
| Pseudomonas aeruginosa | Absence | in 1g | UNE-EN ISO 22717 |
| Candida albicans | Absence | in 1g | UNE-EN ISO 18416 |
| Value | Units | Test Method / Conditions | |
| Glycerin | 68.00 - 69.00 | % | - |
| Morinda Citrifolia Fruit Extract | 29.00 - 31.00 | % | - |
| Citric Acid | 1.00 - 2.00 | % | - |
Regulatory & Compliance
- Certifications & Compliance
- Chemical Inventories
Technical Details & Test Data
- In vivo Testing
- Skin tolerance
Assessment of the skin local tolerance of the studied product after an epicutaneous test performed in occluded conditions, during 48 hours on a panel of 12 healthy adult
volunteers: Patch test method.According to the experimental conditions of the study, the product Quora Noni™ Biomics C 02 can be considered as NON-IRRITANT regarding its primary skin tolerance.
- Skin sensitization (Hypoallergenicity)
Assessment of the irritating and sensitizing potential in vivo of the product Quora Noni™ Biomics C 02 through an HRIPT (Human Repeated Insult Patch Test) performed according to the
Marzulli-Maibach method. The HRIPT was performed during 6 weeks on a panel of 56 healthy adult volunteers.According to the experimental conditions of the study, the product did not cause sensitization in any volunteer so it can be considered NON-IRRITATING, NON-SENSITIZING
and HYPOALLERGENIC.- In vitro Testing
- Cytotoxicity on Human Monocytes (THP-1)
No signs of cytotoxicity were observed at the tested concentrations.
- Cytotoxicity on Human Epidermal Keratinocytes (HEK)
No signs of cytotoxicity were observed at the tested concentrations.
- Evaluation of skin irritation
Assessment of the skin irritation potential of the product Quora Noni™ Biomics C 02 using Reconstructed Human Epidermis (RHE) and the validated Method OECD 439 (In Vitro
EpiDermTM Skin Irritation Test).According to the experimental conditions of the study, the product Quora Noni™ Biomics C 02 is considered NON-IRRITANT for the skin.
- Evaluation of ocular irritation
Assessment of the ocular irritation potential of the product Quora Noni™ Biomics C 02 using the Neutral Red Release (NRR) assay, with rabbit cornea fibroblasts (SIRC cells). This method is
registered in the Official Journal of French Republic (JORF - Decree of 27 December 1999).In the performed experimental conditions, the product Quora Noni™ Biomics C 02, tested by NRR method at 3.30% concentration and according to the JORF classification, presents a
NEGLIGIBLE CYTOTOXICITY.- Mutagenicity test
Assessment of mutagenic potential according to OECD 471 Bacterial reversion mutation test (Ames test). The product was assayed at 5 concentrations ranging from 50 - 5.000 μg/plate.
In the performed experimental conditions, the product Quora Noni™ Biomics C 02 is considered NON MUTAGENIC nor PRO-MUTAGENIC.
Storage & Handling
- Shelf Life
- 18 months
- Storage Instructions
To be stored in hermetically closed vessels at room temperature and protected from direct light and humidity.
- Shelf Life Information
18 months after production, if kept at the recommended storage conditions and the original packaging. We recommend maintaining the container/package well closed as long as possible and observe good hygienic practices in handling.