Knowde Enhanced TDS
Identification & Functionality
- Ingredient Name
- Ingredients
- Elderberries
- Technologies
Features & Benefits
- Food Ingredients Features
- Product Highlights
RibetrilTM A, the patented active compound in MitoActiveTM, is a unique bioactive polyphenolalkaloid found only in specific varieties of red- and blackcurrants. RibetrilTM A displays potent triple enzyme inhibition of IkappaB kinase ß (IKK-ß), phosphodiesterase 4 (PDE4) and phosphodiesterase 5 (PDE5). The triple enzyme inhibitory activity of MitoActiveTM makes sense on a whole new level. Inhibition of PDE4 and PDE5 is linked to activation of PGC-1α, a principal regulator of mitochondrial biogenesis and function. PDE5 inhibition is also known for its ability to induce vascular smooth muscle relaxation. Inhibition of IKK-ß is linked to improved tissue regeneration. IKK-ß is part of the inflammation cascade and related to risk of decreased tissue regeneration capacity.
Applications & Uses
- Markets
- Applications
- Food & Nutrition Applications
Properties
Regulatory & Compliance
- Certifications & Compliance
Technical Details & Test Data
- MitoActive™ for skin is positioned as MitoBeauty™
Berries are generally perceived as the essence of vitality and not without reason; the properties of MitoBeautyTM are truly revitalizing for the skin. MitoBeautyTM was originally researched for its skin healing properties with impressive results. It is clinically documented to significantly increase the microcirculation and moisture of the skin and decrease wrinkles by acting from the inside. MitoBeautyTM is marketed as a skin vitality boosting product with anti-wrinkle properties, available both as liquid and powder. Biotin has been added to the liquid formulation enabling relevant EU authorized health claims (biotin contributes to maintenance of normal skin, hair and mucous membranes). Biotin can be added to the powder (optional).
Skin Regeneration
In a 12 week French clinical study with 50 healthy women and men of 40-65 years of age, supplemented orally with 30 ml of MitoActiveTM with Biotin daily, objective measurements demonstrated:
- Significant anti-wrinkle and smoothing effect already after 6 weeks
- Sustained anti-wrinkle and smoothing effect after12 weeks
- Significantly increased microcirculation in the skinand a significant moisturizing effec
The increased microcirculation strongly supports the finding of an anti-wrinkle effect since regeneration of the skin is dependent on a good blood circulation.
- Mitochondrial boosting by RibetrilTM A
The RibetrilTM A in MitoActiveTM stimulates mitochondrial amount and improves the mitochondrial ability to respond with increased energy output in muscle cells during stress. These parameters are paramount in athletic performance.
Repeated Cooper TestIn a Cooper test on 5 trained athletes supplemented with MitoActiveTM daily for 3 weeks, a significant increase in performance after 2 and 3 weeks of 4.2% and 4.5% compared to baseline was observed. Figure 1 Performance in repeated Cooper tests (relative change). *p < 0.05, **p < 0.001