MitoActive

RibetrilTM A, the patented active compound in MitoActiveTM, is a unique bioactive polyphenolalkaloid found only in specific varieties of red- and blackcurrants. RibetrilTM A displays potent triple enzyme inhibition of IkappaB kinase ß (IKK-ß), phosphodiesterase 4 (PDE4) and phosphodiesterase 5 (PDE5). The triple enzyme inhibitory activity of MitoActiveTM makes sense on a whole new level. Inhibition of PDE4 and PDE5 is linked to activation of PGC-1α, a principal regulator of mitochondrial biogenesis and function. PDE5 inhibition is also known for its ability to induce vascular smooth muscle relaxation. Inhibition of IKK-ß is linked to improved tissue regeneration. IKK-ß is part of the inflammation cascade and related to risk of decreased tissue regeneration capacity.