Products

Soluplus® is a polymeric solubilizer with an amphiphilic chemical structure, which was particularly developed for solid solutions. Due to its bifunctional character, it is able to act as a matrix polymer for solid solutions on the one hand, and, on the other hand, it is capable of solubilizing poorly soluble drugs in aqueous media. Furthermore, Soluplus® can increase the bioavailability of poorly soluble drugs.

Kolliphor® P 407 Micro Geismar is supplied as white to slightly yellowish microbeads. It is readily soluble in water and ethanol and other mainly polar solvents. It is insoluble in ether, paraffin and fatty oils. It offers effective content uniformity, solubilization and increase oral bioavailability of bioactive

Kolliphor® ELP is a white to yellowish paste or cloudy liquid. It is a non-ionic solubilizer made by reacting castor oil with ethylene oxide in a molar ratio of 1:35. This is followed by a purification process. Kolliphor® ELP forms clear solutions in water and also dissolves in a wide range of organic solvents, such as ethanol, n-propanol, isopropanol, ethyl acetate, chloroform, carbon tetrachloride, trichloroethylene, toluene and xylene.

Kollicoat® Smartseal 30 D is insoluble in water (neutral pH) and dissolves quickly under protonation at pH-values of 5.5 and below due to the defined number of basic functional groups. It is a co-polymer comprising methyl methacrylate (MMA) and diethylaminoehtylmethacrylate (DEAEMA) in the ratio 6:4. Kollicoat Smartseal 30 D is an aqueous polymer dispersion (latex) with a faint characteristic odor. It contains approx. 0.6 % macrogol cetostearylether 20 and approx. 0.8% sodium laurylsulfate.

Kollicoat® SR 30 D is an aqueous dispersion with a solids content of 30%. The low viscosity product has a weak characteristic odor and a milky white or slightly yellowish appearance. The dispersion consists of about 27% polyvinyl acetate, 2.7% povidone and 0.3% sodium lauryl sulfate. Kollicoat® SR 30 D is miscible with water in any ratio while retaining its milky-white appearance. Mixing the product with ethanol or isopropyl alcohol in a 1:5 ratio produces a slightly turbid and somewhat viscous solution, a solution in acetone is more turbid. On addition of further organic solvents the polymer precipitates out but then dissolves when further solvent is added. It is insoluble in dilute alkaline or acidic solutions.

Kollicoat® Smartseal 100 P is a spray dried powder of a methyl methacrylate (MMA)and diethylaminoethyl methacrylate (DEAEMA) copolymer. The molar ratio of the monomers MMA and DEAEMA in the copolymer is 7:3. The powder contains approx. 2% macrogol cetostearyl ether and approx. 2.5% sodium lauryl sulfate. It is white and has a pleasant characteristic odor.

Kolliphor® HS15 is a yellowish white paste at room temperature that becomes a liquid at approximately 30°C. It dissolves in water, ethanol and 2-propanol to form clear solutions. Its solubility in water decreases with increasing temperatures. It is insoluble in liquid paraffin.

Kollidon® SR is a mixture of 80% of polyvinyl acetate and 19% povidone (Kollidon® 30) in a physical mixture. Approximately 0.8% of sodium lauryl sulfate and about 0.2% of silica are used as stabilizers. It is supplied as slightly yellowish, free-flowing powder. Kollidon® SR Polymer is insoluble in water and very soluble in N-methylpyrrolidone.

Kolliphor® P 188 Micro Geismar is supplied as white to slightly yellowish microbeads. It is readily soluble in water and ethanol and other mainly polar solvents. It is insoluble in ether, paraffin and fatty oils.

Kolliwax® S Fine is a vegetable based Stearic/Palmitic Acid and is a fine white powder with a typical odor. On account of its consistency giving characteristics the product is mainly used for viscosity regulation in pharmaceutical O/W-emulsions.