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CravingZ’Gone® manages satiety, through the microbiota modulation, is an innovative way to deal with long-term, healthy weight management. In the last two decades, evidence about the role of microbiota in the metabolic engineering in general, and more particularly in weight regulation has accumulated, and it is now admitted that the gut microbiota plays a main role. Key mechanisms linked to the role of microbial metabolites in influencing hormonal profile, inflammation and functioning of the reward centers in the hypothalamus have strengthened the certainty that gut microbiota modulation is probably the next revolution in weight management therapies.