Products in Pharmaceuticals & Nutraceuticals: Solubilizer

KLEPTOSE® HPB Oral Grade is a solubilizer and stabilizer for pharmaceutical and nutraceutical oral dosage applications. Applications Swallowable, chewable and effervescent tablets Lozenges Hard and soft capsules Orally dissolving films Blends Granules Pellets premix Medicated confectionary Syrups Suspensions Liquids Cream Paste Semi-solids Benefits Improves the solubility of poorly soluble compounds Can be used for taste masking of bitter or unpleasant active ingredients

KLEPTOSE® LINECAPS Pea Maltodextrin Cyclodextrin can be used as a solubilizer, stabilizer and taste-making agent in pharma oral dosage applications. Applications Swallowable, chewable and effervescent tablets Lozenges Hard and soft capsules Orally dissolving films Blends Granules Pellets premix Medicated confectionery Syrups Suspensions Liquids Cream Paste Semi-solids

CLEARGUM® CO 03 is a pregelatinized, low-viscosity octenyl succinate starch that can be used as an emulsifier and solubilizer in pharmaceutical and nutraceutical formulations including encapsulation of vitamins or APIs. and as a binder in wet granulation. Benefits BSE-free Halal and Kosher certified Melamine-free Non-GMO Non-hazardous TSE-free Vegan Features Food modified starch (E1450) Free of off-odors Low viscosity Tasteless

KLEPTOSE® HPB Hydroxypropyl Betadex Cyclodextrin is a modified beta-cyclodextrin parenteral grade material that can be used as an encapsulating agent for Rx injectables. Benefits Improves stabilization of active substances against light and oxidation Enhances solubilization of active pharmaceutical ingredients Features White, amorphous powder Molecule is a torus-shaped ring with a polar hydrophilic outside and an apolar hydrophobic cavity

CAVAMAX® W6 Pharma is a pharmaceutical-grade alpha-cyclodextrin from Wacker Chemie AG. With 6 glucose units, it has the smallest cavity among the parent cyclodextrins. It is highly beneficial for solubilizing, stabilizing, or delivering small molecules. It helps in the solubilization, stabilization, and delivery of small active ingredients, e.g. fatty acids.

T-Det® PEG 6000 F is a 100% active polyethylene glycol with an average molecular weight of 6000. It is used to modify therapeutic proteins and peptides to increase their solubility. It appears as white to off-white flakes. T-Det® PEG 6000 F is an effective emulsifier, dispersant, and solubilizer used in a wide range of applications, including personal care products, pharmaceuticals, and industrial formulations. It can also be used as a viscosity modifier, lubricant, and plasticizer.

CAVAMAX® W8 Pharma is pharmaceutical-grade gamma-cyclodextrin from Wacker Chemie AG. This product, with 8 glucose units, has the largest cavity of the parent cyclodextrins and is the most water-soluble. It is useful for solubilizing, stabilizing, or delivering larger molecules, such as macrocyclics, oils, lipids, etc.

CAVAMAX® W7 Pharma is a pharmaceutical-grade beta-cyclodextrin manufactured by Wacker Chemie AG. With its structure composed of seven glucose units, it possesses a mid-size cavity among the parent cyclodextrins. This product is particularly valuable for its ability to stabilize, solubilize, or deliver intermediate-size molecules, such as menthol.

Shin-Etsu AQOAT® AS-HF-Hypromellose acetate succinate (HPMCAS, NF, JP) is an enteric coating material that can be used in aqueous or organic media. It is also used as solubility enhancement of poorly soluble APIs.

Shin-Etsu AQOAT® AS-LF -Hypromellose acetate succinate (HPMCAS, NF, JP) is an enteric coating material that can be used in aqueous or organic media.It is also used as solubility enhancement of poorly soluble APIs.

Shin-Etsu AQOAT® AS-MF -Hypromellose acetate succinate (HPMCAS, NF, JP) is an enteric coating material that can be used in aqueous or organic media.It is also used as solubility enhancement of poorly soluble APIs.

Captex® 100 is a diester formed from a reaction of selected high-purity vegetable fatty acids and propylene glycol. It is Kosher certified. Captex® 100 is totally miscible in mineral oil and in 95% ethanol. It has a lower viscosity than mineral oil. Captex® 100 is an excellent skin emollient and produces a smooth, non-greasy, powdery after-feel with shine. Due to its excellent solvency, Captex® 100 works exceptionally well as a substitute for mineral oil in cosmetic makeup-remover formulas. Because of its unique properties, viscosity, and miscibility with other cosmetic components, Captex® 100 offers advantages in suncare and haircare products where spreadability and shine are desired. The non-oily character, excellent stability, bland taste, and neutral odor make this product an ideal choice as a solubilizer and carrier of vitamins, colors, and flavors for selected pharmaceutical and nutritional formulations, or processing aids such as pan and mold-release agents. It is manufactured in USA.

Caprol® PGE 860 is a very unique product for ABITEC, with the highest HLB of our polyglycerol family. This ingredient is well-known for its slip & foam stabilizing capabilities in rinse off products such as 2-in-1 shampoos. It also provides improved hydration & moisture for healthier looking hair.   Additionally, this food-grade, bio-based ingredient is a premium plasticizer in any range of skincare products aiding in sealed moisture and reduction of dry and flaky skin. It is manufactured in USA.

Caprol® MPGO is a 100% natural plant-based polyglycerol oleate with very unique properties, especially suited for rinse-off applications where a clear formula is preferred. In addition, these ingredients provide a range of emollience properties for skincare products such as, a great moisture barrier, increased moisture retention in the skin, and overall improved skin-feel.This ingredient is produced free from harsh chemicals, making it ideally suited to formulate PEG-free, Sulfate-free, Paraben-free, and safe friendly products for humans & the environment. It is manufactured in USA.

Captex® GTO is a specialty triglyceride manufactured by the esterification of fractionated fatty acids (mainly oleic) and glycerin. Fully refined and deodorized, and with excellent stability, low irritation, bland taste and odor, Captex® GTO is ideally suited for a variety of nutritional and personal care applications. It is manufactured in USA.

Captex® 1000 is a triglyceride formed from selected high-purity vegetable fatty acids and glycerin and carries Kosher certification. Captex® 1000 is an excellent emollient and imparts a pleasant, soft, luxurious, silky, water-resistant film as well as cooling effect to the skin. It provides a sheen and enhanced creamy texture to creams and lotions. Captex® 1000 is recommended for use in skin care creams, lotions and color cosmetics. Due to its sharp melting point and improved lubricity, Captex® 1000 offers advantages in lipstick and lip-treatment products where it imparts a long-lasting, non-greasy feel. The unique alimentation pathway typified by medium-chain triglycerides allows Captex® 1000 to function as an ingredient in cheese analogs, beverages, creamers, and nutritional supplements. Captex® 1000 can be blended with powdered carriers at high levels resulting in a non-greasy, non-oily, free-flowing product. It is manufactured in USA.

Captex® 8000 Medium-Chain Triglycerides originate from renewable vegetable-based sources (typically palm, palm kernel and/or coconut). Captex 8000 is comprised of pure C8 (caprylic) fatty acid, which are food-grade, safe, and responsibly sourced. They are best known for their functional benefits as emulsifiers, solubilizers and refatting agents for use in personal care and cosmetic applications, but also boast numerous health benefits in human nutrition such as weight management, energy, and cognition. It is manufactured in USA.

Captex® 170 EP is an ester prepared from the dehydration of coco fatty alcohols with caprylic and capric acids. It is a polar lipid suitable for solubilizing many types of active ingredients. It may also enhance translocation of API. It is manufactured in USA.

Capmul® MCM is a mono- and diglyceride with unique properties and versatility as a solvent, emulsifier, and emollient for creams, lotions, and rinse-off applications. This high purity distilled monoester is effective as a preservative alternative, based on natural materials, and makes an excellent primary or secondary surfactant in personal care products and cosmetics. It is used to produce stable emulsions, to modify viscosity and can act as a carrier and vehicle in selected applications. It is manufactured in USA.

Captex® 355 Medium-Chain Triglycerides originate from vegetable-based sources (typically palm, palm kernel and/or coconut). These food-grade, safe, responsibly sourced ingredients are best known for their functional benefits as emulsifiers, solubilizers and refatting agents for use in a range of markets and applications. They are preferred lipophilic vehicles and solvents for use in various delivery systems, but are most well-known for their numerous health benefits in areas such as weight management, energy, and cognition.ABITEC offers a variety of C8 (caprylic) and C10 (capric) variations to suite your formulation requirements. It is manufactured in USA.

CAPTEX® 200 is a full-refined ester manufactured by the esterification of selected vegetable fatty acids (mainly caprylic and capric) with propylene glycol. It is miscible with most organic solvents including 95% ethanol. The low viscosity, excellent lubricity, low irritation, and the relatively non-oily character of CAPTEX® 200 makes it ideally suited for a variety of nutritional, personal care, and cosmetic applications. CAPTEX® 200 carries Kosher certification and has excellent stability. It is manufactured in USA.

Capmul® PG-2L EP/NF is a mixture of the propylene glycol mono- and diesters of lauric (dodecanoic) acid. It contains not less than 70.0 percent of diesters and not more than 30.0 percent of monoesters. Capmul® PG-2L EP/NF may be appropriate for microemulsions, soft gelatin capsules, suppositories, suspensions, and/or topical applications. It is manufactured in USA.

These functional lipid excipients act as solubilizers and emulsifiers in oral drug delivery systems. CAPMUL excipients are recognized as the ideal starting point when formulating BCS Class II & IV (poorly water soluble) and BCS Class III & IV (poorly permeable) molecules. Lipid-based drug delivery systems may be formulated as liquid or semi-solid formulations for oral dosage forms. It is manufactured in USA.

CAPMUL® MCM NF is a mixture of monoacylglycerols, obtained by direct esterification of glycerol with caprylic (octanoic) and capric (decanoic) acids. It is manufactured in USA.

Capmul® PG-8-70 NF is Type I Propylene Glycol Monocaprylate, a propylene glycol monoester of caprylic acid. It is an excellent solvent and a good bioavailability enhancer for many complex, poorly soluble drug compounds. Capmul® PG-8-70 NF is used primarily as a carrier in soft and hard gelatin capsules and a penetration enhancer in transdermal drug delivery systems. It is manufactured in USA.

Captex® 200P is propylene glycol diesters of saturated fatty acids, mainly of caprylic and capric acids of vegetable origin. The low viscosity, excellent lubricity, and relatively non-oily character of Captex® 200P makes it ideally suited for a variety of pharmaceutical and clinical nutritional applications, including microemulsions, soft-gelatin capsules, suspensions, and suppositories. It is manufactured in USA.

Capmul® MCM C8 EP/NF is a mixture of monoacylglycerols, containing variable quantities of diand tri-acylglycerols, obtained by direct esterification of glycerol with caprylic (octanoic) acid. It is manufactured in USA.

Captex® 355 EP/NF is manufactured by the esterification of glycerin and fatty acids, mainly caprylic (‰ˆ55%) and capric. It contains not less than 95% of saturated fatty acids with 8 and 10 carbon atoms. It is prepared from raw materials of vegetable sources. It is miscible with most organic solvents including 96% ethanol. It is manufactured in USA.

Acconon® MC8-2 EP/NF is a mixture of monoesters, diesters, and triesters of glycerol and monoesters and diesters of polyethylene glycols with a mean relative molecular weight between 200-400. It may contain free macrogols. It is manufactured in USA.

Oleoyl macrogolglycerides, is a mixture of monoesters, diesters and triesters of glycerol and monoesters and diesters of macrogols (polyethylene glycols (PEG) with a mean relative molecular mass of 300). It is obtained by partial alcoholysis of unsaturated oils containing mainly triglycerides of oleic (cis-9-octadecenoic) acid using macrogol (PEG) or by esterification of glycerol and macrogol (PEG) with unsaturated fatty acids or by mixture of glycerol esters and condensates of ethylene oxide with the fatty acids of these unsaturated oils. The product may contain free polyethylene glycols. It is manufactured in USA.

Captex® 355 EP/NF/JPE is manufactured by the esterification of glycerin and fatty acids, mainly caprylic (‰ˆ55%) and capric. It contains not less than 95% of saturated fatty acids with 8 and 10 carbon atoms. It is prepared from raw materials of vegetable sources. It is manufactured in USA.

Capmul® PG-8 NF is Type II Propylene Glycol Monocaprylate, a propylene glycol monoester of caprylic acid. It is an excellent solvent and a good bioavailability enhancer for many complex, poorly soluble drug compounds. Capmul® PG-8 NF is used primarily as a carrier in soft and hard gelatin capsules and a penetration enhancer in transdermal drug delivery systems. It is manufactured in USA.

Captex® 300 EP/NF is manufactured by the esterification of glycerin and fatty acids, mainly caprylic (‰ˆ70%) and capric. It contains not less than 95% of saturated fatty acids with 8 and 10 carbon atoms. It is prepared from raw materials of vegetable sources. It is miscible with most organic solvents including 96% ethanol. It is manufactured in USA.

Stearoyl macrogolglycerides are mixtures of monoesters, diesters and triesters of glycerol and monoesters and diesters of macrogols (polyethylene glycols (PEG) with a mean relative molecular mass between 300 and 4000). They are obtained by partial alcoholysis of saturated oils containing mainly triglycerides of stearic acid using macrogol (PEG) or by esterification of glycerol and macrogol (PEG) with saturated fatty acids or by mixture of glycerol esters and condensates of ethylene oxide with the fatty acids of these hydrogenated oils. The product may contain free polyethylene glycols, and appears as a pale-yellow, waxy solid. It is manufactured in USA.

Acconon® C-44 EP/NF is a mixture of monoesters, diesters, and triesters of glycerol and monoesters and diesters of polyethylene glycols with a mean relative molecular mass of 1500. It may contain free macrogols. It is manufactured in USA.

Capmul® PG-12 EP/NF is a propylene glycol monoester of lauric acid. It is an excellent solubilizer for many complex poorly soluble drug compounds. Capmul® PG-12 EP/NF is used primarily as a carrier in soft and hard gelatin capsules, a penetration enhancer in transdermal drug delivery systems, and a secondary emulsifier in microemulsions. It is manufactured in USA.