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These functional lipid excipients act as solubilizers and emulsifiers in oral drug delivery systems. CAPMUL excipients are recognized as the ideal starting point when formulating BCS Class II & IV (poorly water soluble) and BCS Class III & IV (poorly permeable) molecules. Lipid based drug delivery systems may be formulated as liquid or semi-solid formulations for oral dosage forms. It is manufactured in USA.

Chemical Name: Glyceryl Caprylate

Functions: Bioavailability Enhancer, Emulsifier, Encapsulant, Supplement

Dosage Form: Capsules, Soft Gels, Tablets

Labeling Claims: Clean Label

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Knowde Enhanced TDS

Identification & Functionality

Chemical Family
Chemical Name
CAS No.
26402-26-6
EC No.
247-668-1

Features & Benefits

Labeling Claims
Product Highlights

Processing Aids

  • Direct-compression, free-fraction tablet lubricants which reduce ejection force but allow for faster disintegration times than surface spreading lubricants
  • Soft gel lubricants which allow for less washing and ease of capsule printing
  • Binder excipients for hot melt granulation and extrusion

Emulsification

  • Functional lipids for primary and secondary emulsification of actives
  • Emulsifiers and surfactants for the formulation of self-emulsifying drug delivery systems (SEDDS)

Lipid Nanoparticle Delivery Systems

  • Functional lipids for the development of solid lipid nanoparticles and nanostructured lipids

Permeation Enhancement

  • Functional lipids which can increase the permeation of BCS Class III and BCS Class IV actives
  • Increase permeation of polar molecules with functional groups which are ionized at biological pH
  • Increase permeation of actives affected by PGP mediated efflux

Controlled Release

  • Formulation of both matrix and encapsulated controlled release
  • Formulation of controlled release multi-particulates for use in tablet and capsule formulations
  • Directly-compressed matrix controlled release tablet formulations

Encapsulation

  • Formulation of functional multi-particulates
  • Use in both matrix and encapsulated multi-particulates
  • Employ in both congealing and molten fluid bed unit operations

Applications & Uses

Manufacturing Technology
Applications
  • Dietary Supplements
  • Beverages
  • Powders

 

Properties

Typical Properties
ValueUnitsTest Method / Conditions
CBD Solubility (Visual)30%w/w
Solubilization
  • Increase the solubility of BCS Class II and BCS Class IV actives
  • Increase the bioavailability of poorly water-soluble actives
  • Both single lipid and self-emulsifying drug delivery system (SEDDS) formulations of poorly water soluble APIs