Knowde Enhanced TDS
Identification & Functionality
- Product Type
- Technologies
- Product Families
Features & Benefits
- Labeling Claims
- Ready-to-Use Product Features
- Features & Benefits
- Anti-thrombogenic: HemoLAST coatings prevent the formation of thrombi in vitro.
- Flexible: Heparin, hirudin, or any one of a number of anti-thrombogenic agents can be incorporated in HemoLAST.
- Aqueous: HemoLAST, as part of the LubriLASTTM family of coatings, contains no organic solvents. Safer and cleaner manufacturing processes are used and any concerns about residual solvents in a device are eliminated.
- Adherent: HemoLAST can be applied to virtually any biomaterial or device with no flaking or delamination.
Applications & Uses
- Markets
Technical Details & Test Data
- How does HemoLAST work?
HemoLASTTM is an anti-thrombogenic coating formulated on the LubriLAST water-based platform. It contains both releasable and covalently bonded anti-thrombogenic agents to provide short and long-term protection against thrombus formation. This is an especially beneficial characteristic for implanted devices. HemoLAST can deliver Heparin as well as other anti-thrombogenic agents such as proteins or peptides.
- HemoLAST Clotting Study
Silicone rubber tubes (10in x i.d. 0.25in) had their lumens coated with HemoLAST or with hydrophilic control. Non heparinized human venous blood was circulated through the tubes (modified Chandler method). The reported clotting time was when the blood ceased to flow. After three hours, the observations were stopped. No anti-thrombotic agents were detectable in the blood, thus indicating that the coating maintained activity and did not leach the bioactive ingredients into the system.
