LUBRILAST LUBRICIOUS HYDROPHILIC MEDICAL COATING

Knowde Enhanced TDS

Identification & Functionality

Product Type: Waterborne Coating
Technologies: Ready-to-Use Products
Product Families: Ready-to-Use Products — Paints & Coatings
Other Paints & Coatings

Features & Benefits

Labeling Claims: Biocompatible,
Solvent-free
Ready-to-Use Product Features: Durable,
Excellent Lubricity,
Flexible,
Hydrophilic
Features & Benefits: Lubricious: LUBRILAST™ coatings virtually eliminate coefficient of friction in aqueous environments.

Aqueous: LUBRILAST™ coatings contain no organic solvents. Safer and cleaner manufacturing processes are used and any concerns about residual solvents in a device are eliminated.

Durable: LUBRILAST™ retains its physical integrity and lubricity even after hundreds of cycles.

Biocompatible: LUBRILAST™ passes all stringent biocompatibility tests associated with tissue and blood contacting devices.

Flexible: LUBRILAST™ withstands, without flaking or delamination, use in the tortuous paths found in physiological systems. It can be applied to balloons used in a number of medical applications.

Applications & Uses

Regulatory & Compliance

Accepted: LubriLAST is patent protected (U.S. Patent Nos. 6,238,799, and 6,866,936) and is in use in a number of approved devices for neurovascular, opthalmic, cardiovascular, urological, and surgical applications. Supporting Device Master File is also available to facilitate customers’ product development and clinical trials.

Technical Details & Test Data

How does LubriLAST work?: In LubriLASTTM, a long chain, biocompatible hydrophilic polymer is incorporated into the coating. Part of this long hydrophilic polymer becomes entangled with the supporting network while other part remains exposed and able to become hydrated. When in the presence of water or body fluids, the hydrophilic polymer adsorbs water molecules to create a watery interface at the surface of the device. The water cushion reduces wet friction, protein adsorption and cell adhesion.
Friction Reduction: Coefficient of Friction Comparisons

SURFACE COEFFICIENT OF FRICTION

Static Kinetic

Uncoated PE 5.89 1.019

Uncoated PET 0.328 1.291

Silicon-oil-coated PET 0.041 0.021

LubriLAST-coated PET 0.009 <0.005

Relative Friction Reduction for Various Substrates
Durability
Biocompatibility: Tissue Biocompatibility

Cytotoxicity

Sensitization test in guinea pigs

Acute intracutaneous reactivity

Pyrogen material mediated test

Systemic toxicity

Hemocompatibility

Direct hemolysis

In vivo thrombogenic resistance study

Complement activation

Coagulation study
Sterilization: Medical Devices Coated With LubriLAST Can Be Sterilized by:

EtO

Gamma

E-beam

Storage & Handling