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- Boswellin CG (Cosmetic grade):> 70-75% boswellic acids, >40% beta boswellic, >10% AKBBA - recommended for cosmetic
Boswellin enter into the composition of other formulation such as Nilitis (Boswellin + Ginger + curcuminoids) Arthriblend / ArthriCare
Boswellia - Powerfull and natural anti-inflammatory
A very powerful anti-inflammatory extract of Boswellia serrata gum, standardized for its content in not only boswellic acid but mainly AKBBA acting on two ways : 5-lipoxygenase and HLE (Human Leukocyte elastase). Its properties are topical or oral use (anti-inflammatory course, but also anti-wrinkle, anti-aging and skin firmness). Grades are not titled as "total boswellic acid" - which means nothing in either since all acids are included - but beta-boswellic and AKBBA.
Typically the Gum Oleoresin of Boswellia is reported to consists of Sesquiterpenoid essential oils (8-12%), Polysaccharides (45-60%), Higher terpenoids, including Boswellic acids (25-35%). The Boswellia acts on the 5-Lipoxygenase pathway (when many other inflammatory works on the COX pathway) which goes to the Leucotrienes. Leukotrienes are fatty acids which are formed from arachidonic acid by an enzyme called Lipoxygenase. Acetyl- keto- beta- boswellic acid (AKBBA) has been shown to be the most potent inhibitor of 5-Lipoxygenase enzyme. Boswellic acids also block the HLE activity. This dual inhibition of HLE and 5- Lipoxygenase enzyme is unique to the Boswellic acids, against rheumatoid Arthritis, osteoarthritis, soft tissue rheumatism, low back pain.
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Technical Details & Test Data
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Boswellin® and knee pain
- The findings of this trial indicate that BS inhibits the secretion of hyaluronic acid into the blood. Compared to the placebo group, the subjective symptoms of knee pain tended to improve. Therefore, BS may be useful to relieve knee pain in Japanese adults.
Boswellia shown effective in osteoarthritis of knee
- All the patients receiving Boswellia serrata extract treatment reported decrease in knee pain, increased knee flexion, and increased walking distance.
Mutagenic, Genotoxic and Sub Chronic Oral Safety of Boswellin® Super
- None of the mutagenic assays showed any increase in mutagenicity above background. Also, the acute oral toxicity and sub chronic toxicity study revealed that Boswellia serrata extract was not lethal to animals up to 2000mg/kg/day when observed for 14 days and 600mg/kg/day when observed for 90 days. Therefore, these data provide evidence that the Boswellia tested have no cytotoxic potency and are not mutagenic. Thus, our findings contribute to the risk assessment of preparations containing Boswellia serrata extract.
Inhibition by Boswellic Acids of Human Leukocyte Elastasesabin
- Screening for additional effects of boswellic acids on further pro inflammatory pathways, we observed that AKBBA, an established direct, nonredox and noncompetitive 5-lipoxygenase inhibitor, decreased the activity of human leukocyte elastase (HLE) in vitro
Toxicity and safety evaluation of boswellic acids
- In view of the above observations it is concluded that BAs are safe for multicentric trials in human subjects
Boswellic acids : nonredox inhibitors of 5-lipoxygenase
- The data strongly suggest that BAs are specific, nonreducing-type inhibitors of the 5-LO product formation either interacting directly with the 5-LO or blocking its translocation
Boswellic acids on the biosynthesis of leukotrienes and autoimmune encephalomyelitis
- The boswellic acids have thus been characterized as selective, non-redox and potent inhibitors of the biosynthesis of leukotrienes in vitro.
Inhibition of Leukotriene B4 Formation by Boswellia
- We conclude that the activity of the 5-LOx itself represents the side of inhibition by the gum resin extract.